5 completed, 1 recruiting. 6 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Completed 5, Recruiting 1 |
| Phase 2 | 1 | Completed 1 |
Follow Splenomegaly: new trials by email Literature Review of Splenomegaly trials Research Report on Splenomegaly
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Therapeutic RSK1 Targeting in Myeloid Malignancies PMD-026 - Myeloid Malignancy | Phase 1 | Recruiting | Washington University School of Medicine | 30 | 2026-05-20 | 2026-10-21 |
| MPN-RC 118 AVID200 in Myelofibrosis AVID200 - Primary Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis | Phase 1 | Completed | John Mascarenhas | 21 | 2019-02-15 | 2023-02-10 |
| Metformin Hydrochloride and Ritonavir in Treating Patients With Relapsed or Refractory Multiple Myeloma or Chronic Lymphocytic Leukemia Laboratory Biomarker Analysis, Metformin Hydrochloride, Pharmacological Study - Anemia, Fatigue | Phase 1 | Completed | City of Hope Medical Center | 3 | 2017-09-07 | 2026-10-19 |
| Valproic Acid (Depakote[Registered Trademark]) to Treat Autoimmune Lymphoproliferative Syndrome (ALPS) Valproic Acid, CT Scan, Blood Sample - ALPS, Hypersplenism | Phase 1 / Phase 2 | Completed | Koneti Rao | 6 | 2008-01-01 | 2013-03-21 |
| Pyrimethamine to Treat Autoimmune Lymphoproliferative Syndrome Pyrimethamine - Autoimmune Disease, Lymphatic Disease | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 8 | 2003-07-01 | 2008-03-04 |
| Pyrimethamine and Sulfadoxine for Treatment of Autoimmune Lymphoproliferative Syndrome Fansidar (pyrimethamine and sulfadoxine) - Autoimmune Disease, Lymphoproliferative Disorder | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 8 | 2001-03-01 | 2008-03-04 |
Lymphadenopathy (4) · Autoimmune Lymphoproliferative Syndrome (3) · Anemia (2) · Autoimmune Diseases (2) · Lymphoproliferative Disorders (2) · Primary Myelofibrosis (2) · Bone Marrow Diseases (1) · Bone Marrow Neoplasms (1) · Fatigue (1) · Fever (1) · Fibrosis (1) · Hematologic Diseases (1) · Hypersplenism (1) · Leukemia, Lymphocytic, Chronic, B-Cell (1)
Hemic and Lymphatic Diseases (6) · Hypertrophy (6) · Pathological Conditions, Anatomical (6) · Pathological Conditions, Signs and Symptoms (6) · Immune System Diseases (4) · Immunoproliferative Disorders (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Genetic Diseases, Inborn (3) · Lymphatic Diseases (3) · Pathologic Processes (3) · Blood Platelet Disorders (2) · Chronic Disease (2) · Disease Attributes (2) · Hematologic Diseases (2) · Leukemia (2)
Pyrimethamine (2) · Blood Specimen Collection (1) · Metformin (1) · Quality of Life (1) · Ritonavir (1) · Sulfadoxine (1) · Surveys and Questionnaires (1) · Valproic Acid (1) · fanasil, pyrimethamine drug combination (1)
National Institute of Allergy and Infectious Diseases (NIAID) (2) · City of Hope Medical Center (1) · John Mascarenhas (1) · Koneti Rao (1) · Washington University School of Medicine (1)
United States (6)
Amy W Zhou, M.D. (1) · John Mascarenhas, MD (1) · Koneti Rao, MD (1) · Nitya Nathwani, MD (1) · Ronald Hoffman, MD (1) · Ruben Mesa, MD (1)
P01CA108671 (1)