17 unknown. 17 Phase 2, 5 Phase 1, 4 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 17 | Unknown 17 |
| Phase 1 | 5 | Unknown 5 |
| Phase 3 | 4 | Unknown 4 |
Follow Scleroderma, Systemic: new trials by email Literature Review of Scleroderma, Systemic trials Research Report on Scleroderma, Systemic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Efficacy of Topical Sodium Metabisulfite for the Treatment of Calcinosis in Patients With Systemic Sclerosis Topical 25% sodium metabisulfite (SM) in pediatric cold cream, Placebo - Systemic Sclerosis, Calcinosis | Phase 1 / Phase 2 | Unknown | Pontificia Universidad Catolica de Chile | 20 | 2024-01-02 | 2023-12-04 |
| Treatment of Systemic Sclerosis With Autologous Regulatory Т-cells Autologous Regulatory Т-cells, Standard treatment according to the clinical protocols - Systemic Sclerosis | Phase 1 / Phase 2 | Unknown | Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus | 30 | 2022-09-01 | 2022-09-14 |
| COvid-19 Vaccine Booster in Immunocompromised Rheumatic Diseases COVID-19 vaccine - Rheumatoid Arthritis, Autoimmune Rheumatologic Disease | Phase 2 / Phase 3 | Unknown | Paul R Fortin | 287 | 2022-03-09 | 2023-01-17 |
| Mycophenolate in Limited Cutaneous Systemic Sclerosis (MINIMISE-Pilot) Mycophenolate Mofetil 500mg - Systemic Sclerosis, Limited Cutaneous Systemic Sclerosis | Phase 2 | Unknown | University College, London | 120 | 2021-12-08 | 2023-07-27 |
| Efficacy and Safety of Rifaximin for Patients With Chronic Intestinal Pseudo-obstruction: a Phase 2 Trial Rifaximin oral tablet, Placebo oral tablet - Chronic Intestinal Pseudo-obstruction | Phase 2 | Unknown | Yokohama City University | 12 | 2019-12-25 | 2021-06-21 |
| A Pilot-Study of Sirolimus for the Treatment of Systemic Sclerosis Sirolimus - Systemic Sclerosis | Phase 2 | Unknown | Peking University People's Hospital | 72 | 2018-06-01 | 2017-12-07 |
| Pirfenidone as Treatment of Skin Fibrosis in Systemic Sclerosis Pirfenidone, Placebo oral capsule, Steroids - Systemic Sclerosis | Phase 2 / Phase 3 | Unknown | RenJi Hospital | 72 | 2017-05-01 | 2017-03-01 |
| SCLERoderma et Adipose-DErived Stroma Cells Stromal Vascular fraction, Ringer lactate - Systemic Sclerosis | Phase 2 | Unknown | Assistance Publique Hopitaux De Marseille | 44 | 2017-01-01 | 2016-08-15 |
| CSL Behring Sclero XIII Fibrogammin®P, coagulation factor XIII concentrate (Human), 0.9% sodium chloride - Systemic Sclerosis | Phase 2 | Unknown | University College, London | 26 | 2015-09-01 | 2016-05-30 |
| Safety and Efficacy Study of Gene Therapy Drug (Neovasculgen) to Treat Secondary Raynaud's Phenomenon Neovasculgen - Secondary Raynaud's Phenomenon | Phase 1 / Phase 2 | Unknown | Artgen Biotech | 30 | 2015-03-01 | 2015-02-05 |
| Clinical Trial of Probiotics in Systemic Sclerosis Associated Gastrointestinal Disease Vivomixx probiotics - Systemic Sclerosis | Phase 2 | Unknown | Singapore General Hospital | 40 | 2013-05-01 | 2018-09-10 |
| Treprostinil Iontophoresis : a Pharmacodynamic and Pharmacokinetic Study Cutaneous iontophoresis of treprostinil - Scleroderma, Systemic | Phase 1 / Phase 2 | Unknown | University Hospital, Grenoble | 40 | 2012-02-01 | 2013-07-18 |
| Allogeneic Mesenchymal Stem Cells Transplantation for Systemic Sclerosis (SSc) Allogeneic Mesenchymal Stem Cells (AlloMSC) - Systemic Sclerosis, Mesenchymal Stem Cells | Phase 1 / Phase 2 | Unknown | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 20 | 2009-08-01 | 2009-08-20 |
| Low-Dose Oral Imatinib for Scleroderma Pulmonary Involvement Imatinib - Systemic Sclerosis | Phase 2 | Unknown | Azienda Ospedaliera Universitaria Policlinico | 30 | 2009-02-01 | 2009-09-03 |
| AIMSPRO in Established Diffuse Cutaneous Systemic Sclerosis Hyperimmune caprine serum, Albumin - Systemic Sclerosis | Phase 2 | Unknown | Daval International Limited | 20 | 2008-12-01 | 2011-08-18 |
| Platelet Gel in Systemic Sclerosis Platelet Gel - Scleroderma, Systemic | Phase 2 / Phase 3 | Unknown | Università Politecnica delle Marche | 40 | 2007-03-01 | 2007-04-20 |
| High Dose Intravenous N-Acetylcysteine Versus Iloprost for Early, Rapidly Progressive Diffuse Systemic Sclerosis N-acetylcysteine (NAC) - Scleroderma, Diffuse | Phase 2 / Phase 3 | Unknown | Università Politecnica delle Marche | 45 | 2007-01-01 | 2007-01-30 |
Scleroderma, Diffuse (4) · Raynaud Disease (2) · Arthritis, Rheumatoid (1) · Calcinosis (1) · Intestinal Pseudo-Obstruction (1) · Lupus Erythematosus, Systemic (1) · MASS syndrome (1) · Scleroderma, Limited (1) · Systemic Vasculitis (1) · Undifferentiated Connective Tissue Diseases (1) · digital ulcers (1)
Connective Tissue Diseases (17) · Skin Diseases (17) · Skin and Connective Tissue Diseases (17) · Cardiovascular Diseases (3) · Vascular Diseases (3) · Embolism and Thrombosis (2) · Livedoid Vasculopathy (2) · Peripheral Vascular Diseases (2) · Skin Diseases, Vascular (2) · Thrombosis (2) · Arthritis (1) · Autoimmune Diseases (1) · Calcium Metabolism Disorders (1) · Digestive System Diseases (1) · Gastrointestinal Diseases (1)
Acetylcysteine (1) · Albumins (1) · COVID-19 Vaccines (1) · Factor VIII (1) · Factor XIII (1) · Imatinib Mesylate (1) · Mycophenolic Acid (1) · Rifaximin (1) · Ringer's Lactate (1) · Saline Solution (1) · Sirolimus (1) · Sodium Chloride (1) · Steroids (1) · pirfenidone (1) · sodium metabisulfite (1)
University College, London (2) · Università Politecnica delle Marche (2) · Artgen Biotech (1) · Assistance Publique Hopitaux De Marseille (1) · Azienda Ospedaliera Universitaria Policlinico (1) · Daval International Limited (1) · Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus (1) · Paul R Fortin (1) · Peking University People's Hospital (1) · Pontificia Universidad Catolica de Chile (1) · RenJi Hospital (1) · Singapore General Hospital (1) · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School (1) · University Hospital, Grenoble (1) · Yokohama City University (1)
Italy (3) · United Kingdom (3) · China (2) · France (2) · Belarus (1) · Canada (1) · Chile (1) · Japan (1) · Russia (1) · Singapore (1)
Andrei Hancharou, Dr (1) · Antonia Valenzuela, MD, MS (1) · Armando Gabrielli, MD (1) · Armando Gabrielli, MD, professor (1) · Armando Gabrielli, MD,professor (1) · Christopher Denton (1) · Christopher Denton, PhD (1) · Christopher P Denton, PhD FRCP (1) · Jean-Luc Cracowski, MD (1) · Kanstantsin Chyzh, Dr (1) · Mu Rong, Poster (1) · Paul R Fortin, MD,MPH,FRCPC (1)
PMID 22542159, PMID 24067785, PMID 25007944, PMID 28270187, PMID 28387950, PMID 28724445, PMID 31208714, PMID 38206544
2014 (1), 2019 (1)