7 completed, 2 unknown, 1 not yet recruiting, 1 withdrawn. 4 Not applicable, 4 Phase 2, 4 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Completed 3, Unknown 1 |
| Phase 2 | 4 | Completed 2, Not yet recruiting 1, Unknown 1 |
| Phase 3 | 4 | Completed 3, Not yet recruiting 1 |
| Phase 1 | 1 | Completed 1 |
Follow Schistosoma Mansoni: new trials by email Literature Review of Schistosoma Mansoni trials Research Report on Schistosoma Mansoni
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Different Treatment Frequencies for Hepatic Fibrosis Due to Schistosomiasis Praziquantel 40 mg/kg per dose given once annually, Praziquantel 40 mg/kg given three times per year - Schistosomiasis, Schistosoma Mansoni | Phase 2 / Phase 3 | Not yet recruiting | Rhode Island Hospital | 600 | 2026-11-01 | 2026-08-12 |
| Sm-p80 Schistosomiasis Challenge Study Sm-p80 + GLA-SE Vaccine, Placebo, Schistosoma mansoni infection - Schistosoma Mansoni, Schistosomiasis | Phase 2 | Unknown | Leiden University Medical Center | 48 | 2024-09-01 | 2023-10-17 |
| Repeated Controlled Human Schistosoma Mansoni Infection Schistosoma mansoni infection, Placebo mock infection - Schistosomiasis, Schistosoma Mansoni | Not applicable | Completed | Leiden University Medical Center | 24 | 2021-10-29 | 2023-01-30 |
| Clinical Evaluation of Ujiplus® Against Schistosoma Mansoni Ujiplus®, Praziquantel 400mg - Schistosoma Mansoni | Phase 2 / Phase 3 | Completed | Kenya Medical Research Institute | 400 | 2021-05-06 | 2022-07-12 |
| Filling Key Research Gaps With Clinical Implications in Mansonellosis and Schistosomiasis: a Network Approach Molecular biology analyses - Schistosoma Mansoni | Not applicable | Unknown | IRCCS Sacro Cuore Don Calabria di Negrar | 200 | 2021-04-14 | 2024-03-15 |
| Evaluation of Artesunate-mefloquine as a Novel Alternative Treatment for Schistosomiasis in African Children Praziquantel, Artesunate + Mefloquine - Schistosoma Haematobium, Schistosoma Mansoni | Phase 3 | Completed | Institute of Tropical Medicine, Belgium | 726 | 2019-10-14 | 2021-04-05 |
| Sm-TSP-2 Schistosomiasis Vaccine in Healthy Ugandan Adults Sm-TSP-2/Alhydrogel® vaccine, Sm-TSP-2/Alhydrogel® vaccine plus AP 10-701, ENGERIX-B Hepatitis B Vaccine - Schistosomiasis, Schistosoma Mansoni | Phase 1 / Phase 2 | Completed | Baylor College of Medicine | 290 | 2019-10-07 | 2025-11-04 |
| Single-sex Controlled Human Schistosomiasis Infection: Safety and Dose Finding male Schistosoma mansoni cercariae - Schistosomiasis, Schistosoma Mansoni | Not applicable | Completed | Leiden University | 17 | 2016-10-27 | 2020-11-18 |
| Leiden University Medical Center Mini Donor Bank Malaria, Schistosoma Mansoni | Withdrawn | Leiden University Medical Center | 2016-05-31 | 2017-08-29 | ||
| Schistosoma Mansoni in Mwanza Region, Tanzania Praziquantel - Schistosoma Mansoni | Not applicable | Completed | DBL -Institute for Health Research and Development | 37500 | 2011-03-01 | 2017-02-10 |
| A Randomised Trial of Artesunate-sulfamethoxypyrazine/Pyrimethamine Versus Praziquantel for the Treatment of S. Mansoni Artesunate+Sulfamethoxypyrazine/pyrimethamine, Praziquantel - Schistosoma Mansoni | Phase 3 | Completed | Kenya Medical Research Institute | 212 | 2009-10-01 | 2010-01-22 |
Schistosomiasis (11) · Schistosomiasis haematobia (2) · Asthma (1) · Diabetes Mellitus (1) · Hypertension, Portal (1) · Liver Cirrhosis (1) · Malaria (1)
Helminthiasis (11) · Infections (11) · Parasitic Diseases (11) · Trematode Infections (11) · Vector Borne Diseases (11) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Male Urogenital Diseases (2) · Urinary Tract Infections (2) · Urogenital Diseases (2) · Urologic Diseases (2) · Bronchial Diseases (1) · Digestive System Diseases (1) · Endocrine System Diseases (1) · Fibrosis (1)
Praziquantel (5) · Artesunate (1) · Mefloquine (1) · Pyrimethamine (1)
Leiden University Medical Center (3) · Kenya Medical Research Institute (2) · Baylor College of Medicine (1) · DBL -Institute for Health Research and Development (1) · IRCCS Sacro Cuore Don Calabria di Negrar (1) · Institute of Tropical Medicine, Belgium (1) · Leiden University (1) · Rhode Island Hospital (1)
Kenya (2) · Netherlands (2) · Uganda (2) · Italy (1) · Senegal (1) · Tanzania (1)
Elijah M Songok, PhD (1) · Hannah Kibuuka, MD (1) · Meta Roestenberg (1) · Meta Roestenberg, Prof (1) · Moustapha Mbow, MD (1) · Pauline N Mwinzi, PhD (1) · Safari Kinung'hi, PhD (1)
PMID 20705516, PMID 30615787, PMID 32066978, PMID 34168029, PMID 38177851, PMID 39666392
R01AI184979 (1)