10 unknown, 6 completed, 6 terminated, 4 withdrawn. 26 Phase 3, 9 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 26 | Unknown 10, Completed 6, Terminated 6, Withdrawn 4 |
| Phase 2 | 9 | Unknown 4, Terminated 3, Completed 1, Withdrawn 1 |
Follow Sars-CoV2: new trials by email Literature Review of Sars-CoV2 trials Research Report on Sars-CoV2
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| TOGETHER - Toronto: Trial to Evaluate the Effect of Peginterferon Lambda for the Treatment of COVID-19 Peginterferon Lambda-1A, Placebo - Sars-CoV2, Covid19 | Phase 3 | Unknown | University Health Network, Toronto | 763 | 2021-08-27 | 2022-04-05 |
| Efficacy and Safety of Favipiravir and Ribavirin Formulation for Treatment of COVID-19 Ribavirin Capsules, Favipiravir - SARS-CoV2, COVID-19 | Phase 2 / Phase 3 | Unknown | The Scientific and Technological Research Council of Turkey | 100 | 2021-04-01 | 2021-04-02 |
| Evaluation of the Efficacy of Nicotine Patches in SARS-CoV2 (COVID-19) Infection in Hospitalized Patients Nicotine 7 mg/ 24h Transdermal Patch - 24 Hour, Placebo of NICOTINE Transdermal patch - SARS-COV2 | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 32 | 2020-12-09 | 2022-02-11 |
| Efficacy and Safety of Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients With Established COVID-19 Linagliptin 5 MG - COVID 19, Coronavirus | Phase 3 | Terminated | Rabin Medical Center | 64 | 2020-10-01 | 2021-06-02 |
| Previfenon® as Chemoprophylaxis of COVID-19 in Health Workers Previfenon®, Placebo - COVID-19, SARS-CoV2 | Phase 2 / Phase 3 | Withdrawn | MELISA Institute Genomics & Proteomics Research SpA | 2020-09-30 | 2026-10-19 | |
| Prevention of COVID19 Infection in Nursing Homes by Chemoprophylaxis With Hydroxychloroquine (PREVICHARM) Hydroxychloroquine Only Product in Oral Dose Form - Sars-CoV2, Coronavirus Infection | Phase 2 / Phase 3 | Unknown | University of Malaga | 1930 | 2020-09-01 | 2020-09-29 |
| Efficacy and Safety of BIO101 in the Prevention of Respiratory Deterioration in Hospitalized COVID-19 Patients BIO101, Placebo - Covid-19, SARS-CoV2 | Phase 2 / Phase 3 | Terminated | Biophytis | 238 | 2020-08-26 | 2026-08-12 |
| Ruxolitinib for Acute Respiratory Disorder Syndrome Due to COVID-19 Janus Kinase Inhibitor (ruxolitinib), Placebo - Severe Acute Respiratory Syndrome Coronavirus 2, SARS-CoV2 | Phase 2 / Phase 3 | Terminated | Vanderson Geraldo Rocha | 5 | 2020-08-14 | 2021-04-08 |
| A Study of LY3819253 (LY-CoV555) and LY3832479 (LY-CoV016) in Preventing SARS-CoV-2 Infection and COVID-19 in Nursing Home Residents and Staff Bamlanivimab, Placebo, Etesevimab - COVID-19, SARS-CoV2 | Phase 3 | Completed | Eli Lilly and Company | 1180 | 2020-08-02 | 2022-02-04 |
| Clinical Trial to Evaluate the Efficacy of RUTI® Against SARS-COV-2 Infection (COVID-19) in Healthcare Workers RUTI® vaccine, Placebo - Covid-19, Sars-CoV2 | Phase 3 | Unknown | Fundació Institut Germans Trias i Pujol | 315 | 2020-07-30 | 2020-07-29 |
| Trial of COVID-19 Outpatient Treatment in Individuals With Risk Factors for Aggravation Vitamins, Telmisartan, Ciclesonide - Corona Virus Infection, Sars-CoV2 | Phase 2 / Phase 3 | Completed | University Hospital, Bordeaux | 412 | 2020-07-29 | 2026-05-12 |
| Prevention, Efficacy and Safety of BCG Vaccine in COVID-19 Among Healthcare Workers BCG vaccine, Placebo - BCG, COVID-19 | Phase 3 | Unknown | Hospital Universitario Dr. Jose E. Gonzalez | 908 | 2020-07-21 | 2020-11-13 |
| CANnabiDiol for CoviD-19 pATiEnts With Mild to Moderate Symptoms Cannabidiol, PLACEBO - SARS-CoV2 | Phase 2 / Phase 3 | Unknown | University of Sao Paulo | 100 | 2020-07-06 | 2021-09-28 |
| Effectiveness and Safety of Convalescent Plasma in Patients With High-risk COVID-19 SARS-CoV-2 convalescent plasma treatment, Standard care - Sars-CoV2, Covid-19 | Phase 2 / Phase 3 | Unknown | Fundación Santa Fe de Bogota | 236 | 2020-07-01 | 2020-06-11 |
| Safety and Efficacy of Hyperbaric Oxygen for ARDS in Patients With COVID-19 Hyperbaric oxygen - SARS (Severe Acute Respiratory Syndrome), Cytokine Storm | Phase 2 / Phase 3 | Terminated | Karolinska Institutet | 34 | 2020-06-03 | 2023-01-09 |
| Efficacy and Safety of Hydroxychloroquine and Favipiravir in the Treatment of Mild to Moderate COVID-19 Favipiravir (3200 mg + 1200 mg), Favipiravir (3600 mg + 1600 mg), Favipiravir (3200 mg + 1200 mg) combined with Hydroxychloroquine - Sars-CoV2, COVID-19 | Phase 3 | Unknown | Ministry of Health, Turkey | 1008 | 2020-05-08 | 2021-02-01 |
| A Study of Hydroxychloroquine and Zinc in the Prevention of COVID-19 Infection in Military Healthcare Workers Hydroxychloroquine, Hydroxychloroquine (placebo), Zinc - Sars-CoV2, COVID19 | Phase 3 | Unknown | Military Hospital of Tunis | 660 | 2020-05-04 | 2020-05-06 |
| BCG Vaccination for Healthcare Workers in COVID-19 Pandemic Bacille Calmette-Guérin (BCG), Placebo Comparator - COVID-19, Sars-CoV2 | Phase 3 | Completed | TASK Applied Science | 1000 | 2020-05-04 | 2022-01-25 |
| Hydroxychloroquine or Diltiazem-Niclosamide for the Treatment of COVID-19 Standard of care (SOC), Hydroxychloroquine, Association of diltiazem and niclosamide - Sars-CoV2 | Phase 3 | Withdrawn | University Hospital, Lille | 2020-05-01 | 2021-03-11 | |
| Honey & Nigella Sativa Trial Against COVID-19 Honey, Nigella Sativa / Black Cumin, Placebos - Coronavirus Infection, Sars-CoV2 | Phase 3 | Completed | Sohaib Ashraf | 313 | 2020-04-30 | 2020-11-12 |
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COVID-19 (21) · Coronavirus Infections (8) · Thrombosis (2) · Cytokine Release Syndrome (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 2 (1) · Endocrine System Diseases (1) · Glucose Metabolism Disorders (1) · Metabolic Diseases (1) · Respiratory Distress Syndrome (1) · Respiratory Tract Diseases (1) · Severe Acute Respiratory Syndrome (1) · Virus Diseases (1)
Infections (23) · Coronaviridae Infections (22) · Nidovirales Infections (22) · RNA Virus Infections (22) · Virus Diseases (22) · Lung Diseases (21) · Pneumonia (21) · Pneumonia, Viral (21) · Respiratory Tract Infections (21) · Respiratory Tract Diseases (20) · Coronavirus Infections (14) · Cardiovascular Diseases (2) · Embolism and Thrombosis (2) · Vascular Diseases (2) · Inflammation (1)
Hydroxychloroquine (7) · Enoxaparin (2) · Heparin (2) · Standard of Care (2) · favipiravir (2) · Azithromycin (1) · BCG Vaccine (1) · COVID-19 Serotherapy (1) · Cannabidiol (1) · Dalteparin (1) · Dosage Forms (1) · Honey (1) · Hyperbaric Oxygenation (1) · Janus Kinase Inhibitors (1) · Linagliptin (1)
Abderrahmane Mami Hospital (1) · Assistance Publique - Hôpitaux de Paris (1) · Biophytis (1) · Centre Hospitalier Universitaire de Saint Etienne (1) · Eli Lilly and Company (1) · Fundació Institut Germans Trias i Pujol (1) · Fundación Santa Fe de Bogota (1) · Hospital Universitario Dr. Jose E. Gonzalez (1) · Karolinska Institutet (1) · Louisiana State University Health Sciences Center in New Orleans (1) · MELISA Institute Genomics & Proteomics Research SpA (1) · Medical University of Vienna (1) · Military Hospital of Tunis (1) · Ministry of Health, Turkey (1) · Northwell Health (1)
France (4) · United States (4) · Brazil (3) · Tunisia (2) · Turkey (Türkiye) (2) · Belgium (1) · Canada (1) · Colombia (1) · Germany (1) · Israel (1) · Mexico (1) · Pakistan (1) · Puerto Rico (1) · South Africa (1) · Spain (1)
Alex C Spyropoulos, MD (1) · Anders Kjellberg, MD (1) · Ayesha Hamayun, MBBS, PhD (1) · Capucine Morelot-Panzini, MD (1) · Elard S Koch, PhD (1) · Faida Ajili, MD (1) · Jalila Ben Khelil, Pr (1) · Jordan Feld, MD (1) · Juan C Morilla-Herrera, PhD (1) · Karine Faure, MD,PhD (1) · Kenny Rodriguez-Wallberg, MD, PhD (1)
PMID 33502773, PMID 34473343, PMID 35244208, PMID 32407672, PMID 33050924, PMID 33430924, PMID 33591017, PMID 34081073, PMID 34226219, PMID 34374951, PMID 34617959, PMID 34619044, PMID 35002970, PMID 35582122, PMID 35713300, PMID 36420866, PMID 37401774, PMID 37510965, PMID 37591523, PMID 38454482, PMID 38545090, PMID 39393522