133 completed, 60 unknown, 13 recruiting, 7 active not recruiting. 83 Not applicable, 61 Phase 1, 20 Phase 2, 16 Phase 4, 6 Early Phase 1.
Follow Safety Issues: new trials by email Literature Review of Safety Issues trials Research Report on Safety Issues
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The HEALiX: Comparing the Efficacy of the HEALiX Device With Wrist Restraints in a Critical Care Setting HEALiX is an alternative restraint patient safety device, soft wrist restraints - Safety Issues, Device Dislodgement | Not applicable | Withdrawn | Milton S. Hershey Medical Center | 2028-08-10 | 2024-12-18 | |
| Phase 1 Study to Evaluate RG002C0106 Injection in Healthy Participants RG002C0106, 0.9% sodium chloride injection - Safety Issues | Phase 1 | Not yet recruiting | Rigerna Therapeutics Co., Ltd.; Rigerna Therapeutics (Beijing) Co., Ltd. | 30 | 2026-12-10 | 2026-10-28 |
| Safety, Tolerability and Pharmacokinetics of ETD-001 Gel Dose 1, dose 2, dose 3 - Safety Issues | Phase 1 | Completed | Etern Therapeutics Wuxi Limited | 56 | 2026-03-16 | 2026-09-10 |
| BeSMART Secure Storage Counseling in the Inpatient Setting Safe Storage Intervention, Safe Kids Medication - Firearm Injury, Safety Issues | Not applicable | Recruiting | Vanderbilt University Medical Center | 400 | 2025-09-20 | 2026-05-11 |
| Safety, Virological and Immunological Assessment of the Controlled Dengue Human Infection Model in Dengue-Immune Participants in Thailand (DHIT-Immune) rDEN2Δ30-7169 - Safety Issues, Dengue | Early Phase 1 | Not yet recruiting | Mahidol University | 12 | 2025-09-01 | 2025-04-03 |
| Safety, Tolerability, PK and PD of SSS55 in Healthy Subjects SSS55 - Safety Issues | Phase 1 | Recruiting | Shenyang Sunshine Pharmaceutical Co., LTD. | 26 | 2025-08-04 | 2026-03-02 |
| Single Ascending Dose and Multiple Ascending Dose Study of AVR-48 AVR-48, Placebo - Safety Issues, Tolerability | Phase 1 | Not yet recruiting | AyuVis Research, Inc. | 48 | 2025-06-01 | 2025-04-06 |
| Study to Evaluate LPH-5 in Healthy Subjects LPH-5, Placebo - Safety Issues, Tolerance | Phase 1 | Not yet recruiting | Lophora | 48 | 2025-04-30 | 2024-12-09 |
| Effect of Lean Leadership Training Program on Head Nurses' Lean Performance and Staff Nurses' Workplace Safety at Mansoura Children Hospital Lean Leadership - Safety Issues | Not applicable | Completed | Mansoura University | 200 | 2025-04-20 | 2025-10-02 |
| Bioequivalence Study of Iron Sucrose Injection in Healthy Participants Iron Sucrose injection (Test product, manufactured by Sichuan Huiyu Pharmaceutical Co., Ltd) and Iron Sucrose injection (Reference product, Venofer), Iron Sucrose injection (Reference product, Venofer) and Iron Sucrose injection (Test product, manufactured by Sichuan Huiyu Pharmaceutical Co., Ltd) - Bioequivalency, Safety Issues | Phase 1 | Completed | Sichuan Huiyu Pharmaceutical Co., Ltd | 48 | 2024-11-22 | 2025-03-24 |
| Adult Trauma Centers RE-AIM at Gun Safety Adopting Comprehensive Training for FireArm Safety in Trauma Centers - Firearm Injury, Safety Issues | Not applicable | Enrolling by invitation | Johns Hopkins University | 1776 | 2024-10-30 | 2026-03-09 |
| A Phase 1 Study to Evaluate the Safety/Tolerability, PK/PD of RG002C0106 Injection in Healthy Adults RG002C0106 - Safety Issues | Phase 1 | Completed | Rigerna Therapeutics Co., Ltd.; Rigerna Therapeutics (Beijing) Co., Ltd. | 50 | 2024-10-18 | 2026-10-15 |
| A Pilot Study of Deep Cervical Lymphatic-venous Anastomosis in the Treatment of Alzheimer's Disease Safety Issues, Feasibility | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 8 | 2024-08-01 | 2024-06-07 | |
| Phase I Study to Evaluate KP405 in Healthy and Parkinson's Disease Patients KP405, Placebo - Safety Issues, Tolerance | Early Phase 1 | Completed | Kariya Pharmaceuticals | 88 | 2024-08-01 | 2026-08-05 |
| NKG2D CAR-T(KD-025) in the Treatment of Advanced NKG2DL+ Solid Tumors KD-025 cell injection - Safety Issues | Not applicable | Unknown | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 9 | 2024-07-17 | 2024-07-19 |
| Active Pharmacovigilance Study of the Medicine Rinvoq™ (Upadacitinib) Upadacitinib - Inflammatory Disease, Drug Side Effect | Unknown | Universidade do Porto | 150 | 2024-07-01 | 2024-07-15 | |
| Safety and Tolerability of 2 Dietary Supplement Beverages Designed to Maintain Healthy Blood Pressure. Treatment 1, Treatment 2, Placebo - Safety Issues, Tolerance | Not applicable | Unknown | USANA Health Sciences | 18 | 2024-07-01 | 2024-06-04 |
| First-Line Treatment Induced With mFOLFOX6 and HLX04 Regimen, Following Combined With Serplulimab in MSS Initially Unresectable Metastatic Colorectal Cancer mfolfox6 and hlx04 regimen and Serplulimab, mfolfox6 and hlx04 regimen - Efficacy, Self, Safety Issues | Phase 2 | Unknown | Sir Run Run Shaw Hospital | 72 | 2024-07-01 | 2024-07-09 |
| Bioequivalence Study of Iron Sucrose Injection in Healthy Subjects Iron Sucrose injection (Test product, manufactured by Sichuan Huiyu Pharmaceutical Co., Ltd) and Iron Sucrose injection (Reference product, Venofer), Iron Sucrose injection (Reference product, Venofer) and Iron Sucrose injection (Test product, manufactured by Sichuan Huiyu Pharmaceutical Co., Ltd) - Bioequivalency, Safety Issues | Phase 1 | Completed | Sichuan Huiyu Pharmaceutical Co., Ltd | 48 | 2024-06-25 | 2024-10-08 |
| Safety-Enhancing Motor Vehicle Child Safety Seat Child restraint system with load leg feature - Motor Vehicle Injury, Safety Issues | Completed | Minnesota HealthSolutions | 50 | 2024-05-22 | 2025-04-16 |
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PMID 28404091, PMID 28404092, PMID 28427875, PMID 29405329, PMID 31199513, PMID 31777965, PMID 32282538, PMID 32304611, PMID 32328827, PMID 33404182, PMID 10340809, PMID 10856276, PMID 15809466, PMID 17050790, PMID 17449587, PMID 18650632, PMID 19136945, PMID 19397800, PMID 20117874, PMID 20351023, PMID 20702147, PMID 21383283, PMID 22054158, PMID 22228716, PMID 22415477, PMID 23163728, PMID 23673863, PMID 23943144, PMID 24776071, PMID 25446262, PMID 26051681, PMID 26369473, PMID 26809671, PMID 26812380, PMID 27011154, PMID 27230467, PMID 27269375, PMID 27501767, PMID 28190771, PMID 28434018, PMID 28637274, PMID 28778687, PMID 28854530, PMID 28877145, PMID 29253918, PMID 29319160, PMID 29355830, PMID 29439736, PMID 29675614, PMID 29696665
2016 (2), 2017 (1), K99AG065419 (1), R01MD019173 (1), R34DK102177 (1), R44DK107231 (1)