24 completed, 2 withdrawn, 1 unknown. 27 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 27 | Completed 24, Withdrawn 2, Unknown 1 |
Follow Rosacea: new trials by email Literature Review of Rosacea trials Research Report on Rosacea
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Brimonidine 0.33% for Rosacea-Related Facial Erythema Brimonidine 0.33% gel, Placebo gel - Rosacea, Rosacea Subtype 1 (Erythematotelangiectatic) | Phase 4 | Completed | Istanbul Training and Research Hospital | 45 | 2025-05-01 | 2026-02-24 |
| Efficacy and Safety of Tranilast Combined With Minocycline in the Treatment of Rosacea minocycline, tranilast - Rosacea | Phase 4 | Unknown | Second Affiliated Hospital of Xi'an Jiaotong University | 45 | 2023-10-16 | 2024-03-12 |
| Changes in PACAP, CGRP, and VIP Levels in Rosacea Patients on Systemic Isotretinoin and Their Association with Erythema İsotretinoin - Rosacea | Phase 4 | Completed | SB Istanbul Education and Research Hospital | 30 | 2023-09-01 | 2025-03-12 |
| Ocular Rosacea Biome Study Doxycycline 40 MG ( 20mg twice daily), Doxycycline 200 MG ( 100 mg twice daily), Placebo - Ocular Rosacea, Antimicrobial Resistance | Phase 4 | Completed | University of California, San Francisco | 46 | 2023-06-22 | 2026-10-27 |
| Intradermal BoNT-A Treatment in Erythematotelangiectatic Rosacea Botulinum toxin A, Placebo - Erythematotelangiectatic Rosacea | Phase 4 | Completed | Istanbul Training and Research Hospital | 30 | 2022-11-01 | 2024-03-29 |
| Efficacy and Safety of Dextenza Compared to Topical Fluorometholone in Patients With Ocular Rosacea Dextenza 0.4Mg Ophthalmic Insert, Fluoromethalone .01% - Ocular Rosacea | Phase 4 | Withdrawn | Eye Associates of Central Texas | 2020-06-06 | 2023-06-18 | |
| A Pilot Study on the Use of Seysara for Rosacea sarecycline, Centrum Adult Multivitamin - Acne Rosacea | Phase 4 | Completed | Derm Research, PLLC | 100 | 2019-04-15 | 2021-01-07 |
| Pulsed Dye Laser Treatment and Oxymetazoline Hydrochloride (HCL) 1% Cream for Erythematotelangiectatic Rosacea The Vbeam® Prima System, Oxymetazoline HCL 1% Cream - Erythematotelangiectatic Rosacea | Phase 4 | Completed | Candela Corporation | 34 | 2019-01-15 | 2022-03-31 |
| Intense Pulsed Light as an Adjunctive to Bromonidine for the Treatment of Rosacea Bromonide 0.33% gel, Intense Pulsed Light (M22) - Rosacea | Phase 4 | Withdrawn | Rabin Medical Center | 2018-12-01 | 2022-10-31 | |
| Azelaic Acid Foam 15% in the Treatment of Papulopustular Rosacea Azelaic Acid foam 15% - Rosacea, Papulopustular | Phase 4 | Completed | Clinical Research Center of the Carolinas | 5 | 2017-12-06 | 2019-07-24 |
| Safety and Tolerability of Oxymetazoline and Energy-Based Therapy in Participants With Rosacea Oxymetazoline HCL 1.0% Cream, Energy-Based Therapy - Rosacea | Phase 4 | Completed | Aclaris Therapeutics, Inc. | 46 | 2017-12-04 | 2019-09-04 |
| Oracea Soolantra Association in Participants With Severe Rosacea Ivermectin 1% cream, Doxycycline 40 mg MR (30 mg Immediate Release & 10 mg Delayed Release beads) capsules, Oral placebo capsules - Rosacea | Phase 4 | Completed | Galderma R&D | 273 | 2017-07-05 | 2021-03-16 |
| Internet Surveys and Their Impact on Adherence for Rosacea brimonidine topical gel 0.33% & survey, brimonidine topical gel 0.33% & SOC - Rosacea | Phase 4 | Completed | Wake Forest University Health Sciences | 20 | 2016-05-05 | 2018-10-10 |
| MirvasO Soolantra Association In the Treatment of Moderate to Severe rosaCea. Brimonidine 0.33% gel (Br), CD07805/47 (Br) placebo gel, Ivermectin 1% cream (IVM) - Rosacea | Phase 4 | Completed | Galderma R&D | 190 | 2015-12-01 | 2021-02-18 |
| Mirvaso in Use Study Brimonidine - Rosacea | Phase 4 | Completed | Galderma R&D | 205 | 2014-09-01 | 2022-08-01 |
| Finacea 15% and Brimonidine 0.33% Gel in the Treatment of Rosacea - A Pilot Study Azelaic acid 15%, Brimonidine 0.33% - Acne Rosacea | Phase 4 | Completed | Derm Research, PLLC | 22 | 2014-05-01 | 2015-09-30 |
| Photodynamic Therapy for Papulopustular Rosacea Aminolevulinic acid topical solution 20%, Blu-U Light Therapy, Placebo vehicle only - Rosacea, Papulopustular Rosacea | Phase 4 | Completed | George Washington University | 30 | 2014-04-24 | 2022-12-29 |
| Patient Centered Outcomes in Rosacea: An Exploratory Multi-media Analysis of the Patient Experience on Oracea Oracea - Papulopustular Rosacea | Phase 4 | Completed | Galderma R&D | 24 | 2013-03-01 | 2022-08-23 |
| Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® vs Placebo Doxycycline, Metronidazole, Placebo - Rosacea | Phase 4 | Completed | Galderma R&D | 235 | 2011-09-01 | 2022-08-01 |
| Evaluation of Rosacea-related Inflammatory Biochemical Markers in Adult Skin When Treated With Oracea® vs Placebo Doxycycline, Placebo - Rosacea | Phase 4 | Completed | Galderma R&D | 170 | 2011-04-01 | 2022-08-01 |
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Telangiectasis (2) · Depression (1) · Erythema (1) · cyclopia sequence (1)
Skin Diseases (27) · Skin and Connective Tissue Diseases (27) · Cardiovascular Diseases (2) · Vascular Diseases (2) · Behavior (1) · Behavioral Symptoms (1) · Pathological Conditions, Signs and Symptoms (1) · Signs and Symptoms (1) · Skin Manifestations (1)
Doxycycline (8) · azelaic acid (5) · Brimonidine Tartrate (4) · Gels (4) · Metronidazole (3) · Ivermectin (2) · Minocycline (2) · Oxymetazoline (2) · Aminolevulinic Acid (1) · Botulinum Toxins, Type A (1) · Calcium Dobesilate (1) · Capsules (1) · Intravital Microscopy (1) · Isotretinoin (1) · Sodium Chloride (1)
Galderma R&D (8) · Derm Research, PLLC (2) · Istanbul Training and Research Hospital (2) · LEO Pharma (2) · Aclaris Therapeutics, Inc. (1) · Candela Corporation (1) · Clinical Research Center of the Carolinas (1) · CollaGenex Pharmaceuticals (1) · Dermatology Specialists Research (1) · Eye Associates of Central Texas (1) · George Washington University (1) · Ophthalmic Consultants of Long Island (1) · Rabin Medical Center (1) · SB Istanbul Education and Research Hospital (1) · Second Affiliated Hospital of Xi'an Jiaotong University (1)
United States (20) · Turkey (Türkiye) (3) · Canada (2) · China (1) · Germany (1) · Hungary (1) · Israel (1)
Ronald W Gottschalk, MD (4) · Alison Ehrlich, MD, MHS (1) · Assi Levi, Dr. (1) · Christopher V Powala, JD (1) · Gerami Seitzman, MD (1) · James M Jackson, MD (1) · Jeffrey Sugarman, MD (1) · John R Wittpenn, MD (1) · Kamaria Nelson, MD (1) · Konika P Schallen, MD (1) · Leon H. Kircik, M.D. (1) · Nancy Alvandi (1) · Steve Feldman, MD (1) · Todd Schlesinger, MD, FAAD (1)
PMID 18071725, PMID 20645521, PMID 23839181, PMID 27718519, PMID 27861741, PMID 31392722, PMID 34233378, PMID 34476755, PMID 34840653, PMID 36539810, PMID 37108184