14 completed, 2 unknown. 16 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 16 | Completed 14, Unknown 2 |
| Phase 2 | 3 | Completed 3 |
Follow Rickets: new trials by email Literature Review of Rickets trials Research Report on Rickets
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effectiveness of Vitamin C Supplementation in Treatment of Rickets Vit C - Nutritional Rickets, Bone Turnover Rate Disorder | Phase 2 / Phase 3 | Completed | Cairo University | 88 | 2022-03-01 | 2023-03-08 |
| Prevention of Spontaneous Dental Abscesses in Children With X-linked Hypophosphatemia : a RCT adhesive system, fluoride varnish, flowable composite - X-linked Hypophosphatemia (XLH) | Phase 3 | Unknown | Assistance Publique - Hôpitaux de Paris | 60 | 2021-06-01 | 2021-05-05 |
| Injection of Teriparatide to Prevent Hypocalcemia After Parathyroidectomy in Dialysis Patients (TeriCa). Teriparatide - Secondary Hyperparathyroidism, Chronic Kidney Disease-Mineral and Bone Disorder | Phase 3 | Completed | Saint Petersburg State University, Russia | 20 | 2021-03-01 | 2022-11-10 |
| Anti-FGF23 (Burosumab) in Adult Patients With XLH Burosumab - X-linked Hypophosphatemia | Phase 3 | Completed | Wuerzburg University Hospital | 36 | 2021-01-07 | 2023-05-03 |
| Study of the Anti-FGF23 Antibody, Burosumab, in Adults With XLH Burosumab - X-linked Hypophosphatemia | Phase 3 | Completed | Kyowa Kirin Pharmaceutical Development Ltd | 35 | 2019-03-07 | 2022-05-20 |
| Open Label Trial Assessing Safety and Efficacy of Burosumab (KRN23), in a Patient With ENS and Hypophosphatemic Rickets Burosumab - Hypophosphatemia, Hypophosphatemic Rickets | Phase 3 | Completed | Redwood Dermatology Sciences | 1 | 2018-01-31 | 2020-01-18 |
| A Study of KRN23 in Pediatric Patients With X-linked Hypophosphatemic Rickets/Osteomalacia KRN23 - X-linked Hypophosphatemic Rickets/Osteomalacia | Phase 3 | Completed | Kyowa Kirin Co., Ltd. | 16 | 2017-07-06 | 2022-09-06 |
| Efficacy and Safety of Burosumab Versus Oral Phosphate and Active Vitamin D Treatment in Pediatric Patients With XLH burosumab, Oral Phosphate Supplement, active vitamin D - X-Linked Hypophosphatemia | Phase 3 | Completed | Kyowa Kirin, Inc. | 61 | 2016-09-08 | 2024-08-29 |
| Open Label Study of KRN23 on Osteomalacia in Adults With X-linked Hypophosphatemia (XLH) burosumab - X-linked Hypophosphatemia | Phase 3 | Completed | Kyowa Kirin, Inc. | 14 | 2015-12-23 | 2024-06-18 |
| Study of KRN23 in Adults With X-linked Hypophosphatemia (XLH) burosumab, Placebo - X-linked Hypophosphatemia | Phase 3 | Completed | Kyowa Kirin, Inc. | 134 | 2015-10-22 | 2024-06-18 |
| Outcome Study of Lanthanum Carbonate Compared With Calcium Carbonate in Hemodialysis Patients : Landmark Study Lanthanum Carbonate, Calcium Carbonate - Hemodialysis, Hyperphosphatemia | Phase 3 | Completed | Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan | 2309 | 2011-12-24 | 2020-11-30 |
| Vitamin D Supplementation in Breastfeeding Women Vitamin D3 - Vitamin D Deficiency, Rickets | Phase 2 / Phase 3 | Completed | Mayo Clinic | 80 | 2010-12-01 | 2013-04-30 |
| Open-Label Study of Asfotase Alfa in Infants and Children ≤ 5 Years of Age With Hypophosphatasia (HPP) asfotase alfa - Hypophosphatasia | Phase 2 / Phase 3 | Completed | Alexion Pharmaceuticals, Inc. | 69 | 2010-07-01 | 2019-03-13 |
| Study Comparing Two Isoforms of Vitamin D Supplements for Infants Cholecalciferol (D3) or ergocalciferol (D2) - Healthy | Phase 3 | Completed | McGill University | 52 | 2010-03-01 | 2012-03-02 |
| Vitamin D3 Substitution in Vitamin D Deficient Kidney Transplant Recipients Cholecalciferol, Placebo - Kidney Transplantation, Vitamin D Deficiency | Phase 3 | Unknown | Medical University of Vienna | 200 | 2009-05-01 | 2014-01-22 |
| Effectiveness of Paricalcitol in Reducing Parathyroid Hormone (PTH) Levels in X-linked Hypophosphatemic Rickets Paricalcitol, Placebo - Hypophosphatemia, Familial, Hyperparathyroidism | Phase 3 | Completed | Yale University | 33 | 2007-01-01 | 2020-03-17 |
Familial Hypophosphatemic Rickets (8) · Chronic Kidney Disease-Mineral and Bone Disorder (3) · Vitamin D Deficiency (3) · Hypophosphatemia (2) · Osteomalacia (2) · Rickets, Hypophosphatemic (2) · Bone Diseases (1) · Breast Feeding (1) · Chronic Pain (1) · Hyperparathyroidism (1) · Hyperparathyroidism, Secondary (1) · Hyperphosphatemia (1) · Hypocalcemia (1) · Hypoparathyroidism (1)
Avitaminosis (16) · Bone Diseases, Metabolic (16) · Calcium Metabolism Disorders (16) · Deficiency Diseases (16) · Malnutrition (16) · Metabolic Diseases (16) · Musculoskeletal Diseases (16) · Nutrition Disorders (16) · Nutritional and Metabolic Diseases (16) · Bone Diseases (15) · Vitamin D Deficiency (13) · Female Urogenital Diseases (11) · Female Urogenital Diseases and Pregnancy Complications (11) · Kidney Diseases (11) · Male Urogenital Diseases (11)
burosumab (7) · Cholecalciferol (3) · Calcium Carbonate (1) · Ergocalciferols (1) · Teriparatide (1) · asfotase alfa (1) · flowable hybrid composite (1) · lanthanum carbonate (1) · paricalcitol (1)
Kyowa Kirin, Inc. (3) · Alexion Pharmaceuticals, Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · Cairo University (1) · Kyowa Kirin Co., Ltd. (1) · Kyowa Kirin Pharmaceutical Development Ltd (1) · Mayo Clinic (1) · McGill University (1) · Medical University of Vienna (1) · Redwood Dermatology Sciences (1) · Saint Petersburg State University, Russia (1) · Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan (1) · Wuerzburg University Hospital (1) · Yale University (1)
United States (7) · Japan (6) · Canada (4) · France (4) · United Kingdom (4) · Italy (3) · South Korea (3) · Australia (2) · Germany (2) · Ireland (2) · Russia (2) · Austria (1) · Denmark (1) · Egypt (1) · Saudi Arabia (1)
Celia Rodd, MD (1) · Fatina Fadel, Prof (1) · Hope A, Weiler, PhD, RD (1) · Jeffrey Sugarman, MD PhD (1) · Kyra Borchhardt, MD (1) · Lothar Seefried, MD (1) · Peter Kamenicky (1) · Sina Gallo, MSc, RD (1) · Tadao Akizawa, MD, PhD (1) · Thomas O. Carpenter, MD (1) · Thomas Thacher, MD (1)
PMID 39151033, PMID 36854566, PMID 19480654, PMID 23256143, PMID 24290111, PMID 25029424, PMID 26529632, PMID 29486367, PMID 29947083, PMID 30811537, PMID 31104833, PMID 31165191, PMID 32721016, PMID 32762706, PMID 33305842, PMID 33484279, PMID 34003226, PMID 34548383, PMID 35533340, PMID 35775373, PMID 35927518, PMID 36719566, PMID 37084401, PMID 40576086
2014 (1), P50AR054086 (1)