13 completed, 1 recruiting, 1 terminated, 1 unknown. 16 Phase 1, 9 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 16 | Completed 13, Recruiting 1, Terminated 1, Unknown 1 |
| Phase 2 | 9 | Completed 8, Recruiting 1 |
Follow Rickets: new trials by email Literature Review of Rickets trials Research Report on Rickets
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A First-in-human Study of KK8123 in Adults With X-linked Hypophosphatemia KK8123 - X-linked Hypophosphatemia | Phase 1 / Phase 2 | Recruiting | Kyowa Kirin Co., Ltd. | 39 | 2024-10-09 | 2026-11-06 |
| Study to Assess the Safety, Tolerability, Pharmacokinetics and Efficacy of Burosumab in Patients Less Than 1 Year of Age Burosumab - X-linked Hypophosphatemia (XLH) | Phase 1 / Phase 2 | Completed | Kyowa Kirin Pharmaceutical Development Ltd | 16 | 2020-02-26 | 2024-11-07 |
| Ga-DOTATATE PET for Phosphaturic Mesenchymal Tumors in Patients With Tumor Induced Osteomalacia 68Ga-DOTATATE PET/CT - Osteomalacia | Phase 1 / Phase 2 | Completed | Mayo Clinic | 18 | 2019-01-31 | 2025-04-30 |
| A Study of KRN23 in Subjects With X-linked Hypophosphatemic Rickets/Osteomalacia KRN23 - X-linked Hypophosphatemic Rickets/Osteomalacia | Phase 1 | Completed | Kyowa Kirin Co., Ltd. | 15 | 2014-07-01 | 2017-03-03 |
| Cinacalcet for Fibroblast Growth Factor 23 (FGF23)-Mediated Hypophosphatemia (Hypophosphatemic Rickets) Osteomalacia - Osteomalacia | Phase 1 | Terminated | National Institute of Dental and Craniofacial Research (NIDCR) | 1 | 2012-11-16 | 2018-07-05 |
| An Extension Study of KRN23 in Adults With X-Linked Hypophosphatemia KRN23 - X-linked Hypophosphatemia | Phase 1 / Phase 2 | Completed | Kyowa Kirin Co., Ltd. | 23 | 2012-02-01 | 2024-06-18 |
| A Repeated Study of KRN23 in Adults With X-Linked Hypophosphatemia KRN23 - X-linked Hypophosphatemia | Phase 1 / Phase 2 | Completed | Kyowa Kirin Co., Ltd. | 29 | 2011-04-01 | 2024-06-18 |
| A Study of KRN23 in X-linked Hypophosphatemia Placebo, KRN23 - X-linked Hypophosphatemia | Phase 1 | Completed | Kyowa Kirin Co., Ltd. | 42 | 2008-12-01 | 2024-06-17 |
| Safety and Efficacy Study of Asfotase Alfa in Severely Affected Infants With Hypophosphatasia (HPP) asfotase alfa - Hypophosphatasia (HPP) | Phase 1 / Phase 2 | Completed | Alexion Pharmaceuticals, Inc. | 11 | 2008-09-01 | 2019-04-01 |
| Safety Study of Human Recombinant Tissue Non-Specific Alkaline Phosphatase Fusion Protein Asfotase Alfa in Adults With Hypophosphatasia (HPP) Asfotase Alfa - Hypophosphatasia (HPP) | Phase 1 | Completed | Alexion Pharmaceuticals, Inc. | 6 | 2008-08-01 | 2019-03-29 |
| The Effect of Oral Niacinamide on Plasma Phosphorus Levels in Peritoneal Dialysis Patients Niacinamide, Placebo - Hyperphosphatemia | Phase 1 / Phase 2 | Completed | Washington University School of Medicine | 17 | 2006-10-01 | 2007-07-30 |
| The Effect of Oral Niacinamide on Serum Phosphorus Levels in Hemodialysis Patients Niacinamide - Hyperphosphatemia | Phase 1 | Completed | Washington University School of Medicine | 40 | 2006-04-01 | 2009-01-16 |
| Growth Hormone Treatment in Children With Hypophosphatemic Rickets norditropine simplex - X Linked Hypophosphatemic Rickets | Phase 1 / Phase 2 | Completed | Bicetre Hospital | 19 | 2006-01-01 | 2016-03-28 |
| Effect of Cinacalcet on Parathyroid Hormone Secretion in Children and Adolescents With Hypophosphatemic Rickets Cinacalcet - Hypophosphatemic Rickets, X-Linked Dominant | Phase 1 | Completed | Children's Mercy Hospital Kansas City | 8 | 2005-06-01 | 2021-01-19 |
| Nursing-Home Residents Given Bread Fortified With Vitamin D3 Bread fortified with vitamin D3 and calcium - Vitamin D Deficiency, Low Bone Density | Phase 1 / Phase 2 | Completed | University of Toronto | 45 | 2004-11-01 | 2008-11-13 |
| Effects of GH on Body Proportions and Final Height in X-Linked Hypophosphatemic Rickets somatropin - Hypophosphatemic Rickets, Growth Disorders | Phase 1 | Unknown | University of Rostock | 2004-08-01 | 2007-05-14 |
Familial Hypophosphatemic Rickets (9) · Osteomalacia (6) · Bone Diseases (3) · Chronic Kidney Disease-Mineral and Bone Disorder (2) · Hyperphosphatemia (2) · Hypophosphatasia (2) · Kidney Failure, Chronic (2) · Rickets, Hypophosphatemic (2) · Bone Diseases, Metabolic (1) · Growth Disorders (1) · Hypophosphatemia (1) · Kidney Diseases (1) · Metabolic Diseases (1) · Musculoskeletal Diseases (1)
Avitaminosis (16) · Calcium Metabolism Disorders (16) · Deficiency Diseases (16) · Malnutrition (16) · Nutrition Disorders (16) · Nutritional and Metabolic Diseases (16) · Bone Diseases, Metabolic (15) · Metabolic Diseases (15) · Musculoskeletal Diseases (15) · Vitamin D Deficiency (15) · Bone Diseases (13) · Phosphorus Metabolism Disorders (12) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (11) · Female Urogenital Diseases (11)
burosumab (5) · Niacinamide (2) · asfotase alfa (2) · Calcium (1) · Cholecalciferol (1) · Cinacalcet (1) · Growth Hormone (1) · Human Growth Hormone (1)
Kyowa Kirin Co., Ltd. (5) · Alexion Pharmaceuticals, Inc. (2) · Washington University School of Medicine (2) · Bicetre Hospital (1) · Children's Mercy Hospital Kansas City (1) · Kyowa Kirin Pharmaceutical Development Ltd (1) · Mayo Clinic (1) · National Institute of Dental and Craniofacial Research (NIDCR) (1) · University of Rostock (1) · University of Toronto (1)
United States (11) · Canada (5) · France (2) · Germany (2) · Spain (2) · United Kingdom (2) · Austria (1) · Italy (1) · Japan (1) · South Korea (1) · Sweden (1) · United Arab Emirates (1)
Amy Zhang, PhD (2) · Daniel O Young, MD (1) · Daniel W Coyne, M.D> (1) · Dieter Haffner, MD (1) · Dirk Schnabel, MD (1) · Hagen Staude (1) · Matthew Drake, MD (1) · Rachel I Gafni, M.D. (1) · Rachel Levy-Olomucki, MD (1) · Stephen M Broski, MD (1) · Thomas O. Carpenter, M.D. (1)
PMID 25919461, PMID 40576086, PMID 18385391, PMID 19244376, PMID 19776051, PMID 22397652, PMID 24120120, PMID 24569459, PMID 26073451, PMID 26529632, PMID 28822957, PMID 32762706, PMID 39151033, PMID 42044650