170 completed, 35 unknown, 18 terminated, 15 recruiting. 67 Phase 3, 43 Phase 2, 42 Not applicable, 26 Phase 4, 22 Phase 1.
Follow Phosphorus Metabolism Disorders: new trials by email Literature Review of Phosphorus Metabolism Disorders trials Research Report on Phosphorus Metabolism Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Respiratory Quotient and Phosphate Changes During Early Critical Illness Nutritional Exposure During Early Critical Illness - Refeeding Syndrome, Critical Illness | Not yet recruiting | Vastra Gotaland Region | 40 | 2026-11-01 | 2026-09-02 | |
| Tenapanor in Maintenance Hemodialysis Patients Tenapanor - Hyperphosphatemia, Maintenance Hemodialysis | Not yet recruiting | Huashan Hospital | 70 | 2026-09-23 | 2026-10-20 | |
| Morphology in Oral Rare Syndromes & Artificial Intelligence for Clinical Diagnosis intra-oral 3D optical impression - Osteogenesis Imperfecta, Rare Bone Disorders | Not applicable | Not yet recruiting | University Hospital, Bordeaux | 240 | 2026-09-01 | 2026-06-24 |
| Phosphate in Acute Pancreatitis Sodium Phosphate, Potassium Phosphate - Pancreatitis | Phase 2 | Recruiting | Duke University | 100 | 2026-07-09 | 2026-08-26 |
| Treatment Patterns, Biochemical Profiles and Clinical Outcomes in Adults With X-Linked Hypophosphatemia No treatment given - X-linked Hypophosphatemia (XLH) | Withdrawn | Novo Nordisk A/S | 2026-07-07 | 2026-08-28 | ||
| A Study to Evaluate Safety, Tolerability and Efficacy of AP306 at Fixed Doses in Dialysis Participants With Hyperphosphatemia AP306 75 mg BID, AP306 125 mg BID, AP306 150 mg BID - Hyperphosphatemia, Chronic Kidney Disease Requiring Chronic Dialysis | Phase 2 | Recruiting | R1 Therapeutics | 168 | 2026-06-01 | 2026-08-26 |
| Protocolised Management of Phosphate Replacement Trial Liberal Phosphate Replacement Protocol, Restrictive Phosphate Replacement Protocol - Phosphate Deficiency, Hypophosphatemia | Not applicable | Not yet recruiting | Caboolture Hospital | 2400 | 2026-01-01 | 2025-12-17 |
| Enteral Supplementation With Sodium Dihydrogen Phosphate and Disodium Hydrogen Phosphate Granules for the Treatment of Hypophosphatemia. Sodium Dihydrogen Phosphate and Disodium Hydrogen Phosphate Granules - Hypophosphatemia | Not applicable | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 60 | 2025-11-21 | 2025-11-28 |
| Effective Dosing of Burosumab in XLH X-linked Hypophosphatemia (XLH) | Recruiting | University of Nottingham | 120 | 2025-11-03 | 2026-05-11 | |
| A Study of a Novel Iron-based Phosphate Binder AP301 in Patients With Hyperphosphatemia in the U.S. and China AP301, AP301 Low Dose - Hyperphosphatemia, Chronic Kidney Disease, Receiving Dialysis | Phase 3 | Recruiting | Alebund Pharmaceuticals | 264 | 2025-06-13 | 2026-01-29 |
| Institution of an Italian Multicenter Database of Patients Affected by Diseases of Phosphate Metabolism Phosphate Deficiency, Phosphate Overload | Not yet recruiting | F.I.R.M.O. - Fondazione Italiana Ricerca sulle Malattie dell'Osso - Ente del Terzo Settore | 100 | 2025-06-01 | 2025-02-14 | |
| Phosphorus-31 Spectroscopy in Phosphate Diabetes intra-muscular ATP values in phosphate diabetes, intra-muscular phosphate values in phosphate diabetes - Phosphate Diabetes, X-linked Hypophosphatemia | Not applicable | Recruiting | Hospices Civils de Lyon | 65 | 2025-05-16 | 2026-07-23 |
| Evaluation of Dipyridamole in Preventing Post-Transplant Hypophosphatemia in Kidney Transplant Recipients Dipyridamole 75 MG - Hypophosphatemia, Kidney Transplantation | Phase 2 | Recruiting | Stanford University | 90 | 2025-05-15 | 2026-06-11 |
| Evaluate the Efficacy and Safety of JMKX003002 in End-Stage Renal Disease Patients on Hemodialysis with Hyperphosphatemia JMKX003002 will be administered orally, Sevelamer carbonate - Hyperphosphatemia | Phase 2 | Recruiting | Jemincare | 50 | 2024-12-30 | 2025-02-03 |
| A First-in-human Study of KK8123 in Adults With X-linked Hypophosphatemia KK8123 - X-linked Hypophosphatemia | Phase 1 / Phase 2 | Recruiting | Kyowa Kirin Co., Ltd. | 39 | 2024-10-09 | 2026-09-21 |
| Phosphate Diet Strategies to Lower Blood Phosphate in Dialysis Patients diet education - Hyperphosphataemia, Phosphorus | Not applicable | Completed | Kufa University | 200 | 2024-10-01 | 2025-09-18 |
| Effect of Hypophosphatemia on Neuro-excursion Efficiency During Mechanical Ventilator Weaning Sodium Glycerophosphate 216 MG/ML - Mechanical Ventilation, Weaning Failure | Recruiting | Peking Union Medical College | 70 | 2024-10-01 | 2025-05-31 | |
| IV Iron-induced Hypophosphatemia After RYGB Iron isomaltoside, Iron Carboxymaltose - Hypophosphatemia, Roux-en-Y Gastric Bypass | Phase 4 | Unknown | Lucie Favre | 94 | 2024-05-02 | 2024-08-20 |
| Metabolic Pathway Analysis in Intensive Care Unit Patients With Refeeding Syndrome Metabolomics - Critical Illness, Refeeding Syndrome | Completed | Karolinska University Hospital | 218 | 2024-04-01 | 2025-04-02 | |
| Effect of Burosumab on the Inflammatory Profile of Patients With X-linked Hypophosphatemic Rickets FLAM-XLH Expression of inflammatory markers (Il6, Il8, Il1β, CXCL1, CCL2, CXCR3, Il1R, Il6R) - X-Linked Hypophosphatemic Rickets | Unknown | Hospices Civils de Lyon | 20 | 2024-04-01 | 2024-03-06 |
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Hyperphosphatemia (164) · Renal Insufficiency, Chronic (61) · Familial Hypophosphatemic Rickets (49) · Hypophosphatemia (48) · Kidney Failure, Chronic (38) · Renal Insufficiency (18) · Kidney Diseases (13) · Rickets, Hypophosphatemic (9) · Rickets (7) · Anemia, Iron-Deficiency (6) · Chronic Kidney Disease-Mineral and Bone Disorder (6) · Hypophosphatemia, Familial (6) · Refeeding Syndrome (6) · Hyperparathyroidism (5) · Osteomalacia (5)
Nutritional and Metabolic Diseases (257) · Metabolic Diseases (255) · Female Urogenital Diseases and Pregnancy Complications (157) · Urogenital Diseases (157) · Female Urogenital Diseases (156) · Male Urogenital Diseases (155) · Urologic Diseases (153) · Kidney Diseases (142) · Pathological Conditions, Signs and Symptoms (107) · Pathologic Processes (101) · Disease Attributes (97) · Chronic Disease (93) · Renal Insufficiency (78) · Nutrition Disorders (71)
Sevelamer (37) · burosumab (21) · lanthanum carbonate (21) · ferric citrate (16) · calcium acetate (11) · Calcium Carbonate (9) · cholebine (9) · tenapanor (8) · sucroferric oxyhydroxide (5) · Cinacalcet (4) · iron-magnesium hydroxycarbonate (4) · Calcitriol (3) · Educational Status (3) · Niacinamide (3) · Nutrition Assessment (3)
Kyowa Kirin Co., Ltd. (17) · Bayer (11) · Tanabe Pharma Corporation (10) · Astellas Pharma Inc (8) · Ardelyx (6) · Genzyme, a Sanofi Company (6) · Keryx Biopharmaceuticals (6) · Kyowa Kirin, Inc. (6) · Hospices Civils de Lyon (5) · Kissei Pharmaceutical Co., Ltd. (5) · Kyowa Kirin Pharmaceutical Development Ltd (5) · Ineos Healthcare Limited (4) · National Institute of Dental and Craniofacial Research (NIDCR) (4) · Shire (4) · Yale University (4)
United States (89) · Japan (41) · France (34) · United Kingdom (31) · Germany (27) · China (22) · Italy (21) · Canada (14) · Spain (14) · Poland (11) · Denmark (10) · Australia (9) · Austria (8) · Netherlands (8) · Belgium (7)
Geoffrey A Block, MD (4) · Julia B Lewis, MD (4) · David P Rosenbaum, PhD (3) · Amy Zhang, PhD (2) · Geoff Block, MD (2) · Joseph Eustace, MB (2) · Rachel I Gafni, M.D. (2) · Wajeh Y Qunibi, M.D. (2)
PMID 40576086, PMID 39151033, PMID 38323855, PMID 37853560, PMID 32721016, PMID 40962182, PMID 42664364, PMID 21854503, PMID 23797006, PMID 25919461, PMID 32016310, PMID 36854566, PMID 10231464, PMID 11260415, PMID 11334065, PMID 11422774, PMID 12373466, PMID 12376810, PMID 12608553, PMID 12761615, PMID 14600809, PMID 14750100, PMID 15256798, PMID 15296888, PMID 15855212, PMID 15930998, PMID 16453140, PMID 16696865, PMID 16698131, PMID 16879061, PMID 16932387, PMID 17060000, PMID 17071958, PMID 17342691, PMID 17507907, PMID 17699189, PMID 18385391, PMID 18402655, PMID 18423809, PMID 18432588, PMID 18492867, PMID 18820097, PMID 18843706, PMID 19089795, PMID 19114912, PMID 19211470, PMID 19255959, PMID 19426417, PMID 19539185, PMID 19776051
2008 (3), 1UL1TR001863-01 (1), 2009 (1), 2014 (1), P50AR054086 (1), R01DK142980 (1), R21AR061818 (1)