6 completed, 6 unknown, 3 not yet recruiting, 1 terminated. 5 Not applicable, 5 Phase 2, 4 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 2, Not yet recruiting 2, Unknown 1 |
| Phase 2 | 5 | Completed 2, Unknown 2, Not yet recruiting 1 |
| Phase 3 | 4 | Completed 2, Unknown 2 |
Follow Refractory Ascites: new trials by email Literature Review of Refractory Ascites trials Research Report on Refractory Ascites
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fiber-Optic Navigation During TIPS Creation: A Prospective Pilot Study Fiber-Optic Navigation System - Liver Cirrhosis, Refractory Ascites | Not applicable | Not yet recruiting | Medical University Innsbruck | 30 | 2027-01-01 | 2026-03-13 |
| Personalized Nutritional Intervention in Patients Undergoing TIPS Insertion for Refractory Ascites to Prevent Overt Hepatic Encephalopathy High Energy and High Protein Diet 1, High Energy and High Protein Diet 2 - Cirrhosis, Refractory Ascites | Not applicable | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 50 | 2026-06-15 | 2026-06-08 |
| Clinical Study to Evaluate the Efficacy and Safety of Dapagliflozin in Patients With Refractory Cirrhotic Ascites Dapagliflozin 5mg, Standard care treatment - Refractory Ascites | Phase 2 | Not yet recruiting | Mansoura University | 70 | 2025-04-15 | 2025-04-09 |
| Transjugular Intrahepatic Portosystemic Shunts Improve Survival in Patients With Cirrhosis and Recurrent Ascites transjugular intrahepatic portal shunt - Refractory Ascites | Completed | Tang-Du Hospital | 462 | 2023-12-01 | 2024-08-27 | |
| Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Refractory Ascites Echocardiographic assessment - Cirrhosis, Liver, Acute-On-Chronic Liver Failure | Unknown | Post Graduate Institute of Medical Education and Research, Chandigarh | 80 | 2022-11-15 | 2023-09-21 | |
| Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Hepatorenal Syndrome-Acute Kidney Injury Echocardiographic assessment - Hepatorenal Syndrome, Cirrhosis, Liver | Unknown | Post Graduate Institute of Medical Education and Research, Chandigarh | 75 | 2021-12-15 | 2023-05-01 | |
| Midodrine and Albumin in Patients With Refractory Ascites Albumin, Midodrine, Standard medical therapy (SMT) - Refractory Ascites | Phase 3 | Unknown | Post Graduate Institute of Medical Education and Research, Chandigarh | 114 | 2020-11-01 | 2020-11-09 |
| Safety and Efficacy of Midodrine Hydrochloride in the Management of Refractory Ascites Due to Cirrhosis in Children Midodrine 2.5 mg tab - Refractory Ascites, Children, Only | Not applicable | Unknown | National Liver Institute, Egypt | 20 | 2020-06-05 | 2020-08-24 |
| Evaluation of Hemodynamic Parameters Following Transjugular Intrahepatic Portosystemic Shunt (TIPS) Study - Transjugular Intrahepatic Portosystemic Shunt (TIPS), Control - Transjugular Intrahepatic Portosystemic Shunt (TIPS) - Refractory Ascites | Not applicable | Completed | Medical College of Wisconsin | 50 | 2019-09-25 | 2024-12-13 |
| Glutamine Challenge as Predictor of Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt (TIPS) Oral glutamine challenge, Psychometric Tests - Refractory Ascites, Hepatic Hydrothorax | Terminated | University of Arkansas | 3 | 2013-05-01 | 2017-04-17 | |
| ALFApump System Post Marketing Surveillance Registry Liver Cirrhosis, Refractory Ascites | Completed | Sequana Medical N.V. | 100 | 2012-06-01 | 2020-10-26 | |
| Infrared Ray Heat Treatment in Liver Cirrhosis Patients With Refractory Ascites Infrared ray heat treatment, conventional treatment - Liver Cirrhosis, Refractory Ascites | Phase 2 / Phase 3 | Unknown | First People's Hospital of Foshan | 40 | 2012-03-01 | 2012-03-21 |
| The Effectiveness of L-ornithine-L-aspartate (LOLA) on Plasma Ammonia in Cirrhotic Patients After TIPS L-ornithine-L-aspartate - Decompensated Cirrhosis, Portal Hypertension | Phase 2 / Phase 3 | Completed | Air Force Military Medical University, China | 40 | 2011-12-01 | 2012-12-19 |
| Effects of Treatment of Ascites by the ALFApump System on Renal and Circulatory Function ALFApump system - Cirrhosis, Liver, Refractory Ascites | Phase 2 | Unknown | Sequana Medical N.V. | 12 | 2011-09-01 | 2016-08-11 |
| A Feasibility Study of the Automated Fluid Shunt (AFS) for Automated Ascites Removal AFS System - Refractory Ascites | Not applicable | Completed | NovaShunt AG | 7 | 2008-12-01 | 2011-12-19 |
| The Use of Drugs to Improve Kidney Function in Patients With Liver and Kidney Dysfunction Midodrine, albumin, octreotide LAR, midodrine, octreotide, albumin - Type 2 Hepatorenal Syndrome, Refractory Ascites | Phase 2 / Phase 3 | Completed | University of Alberta | 9 | 2005-10-01 | 2007-12-06 |
Ascites (16) · Liver Cirrhosis (7) · Fibrosis (3) · Hypertension, Portal (3) · Acute-On-Chronic Liver Failure (2) · Hepatorenal Syndrome (2) · Acute Kidney Injury (1) · Hepatic Encephalopathy (1) · Hydrothorax (1)
Pathologic Processes (16) · Pathological Conditions, Signs and Symptoms (16) · Digestive System Diseases (9) · Liver Diseases (9) · Fibrosis (7) · Female Urogenital Diseases (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Hepatic Insufficiency (3) · Kidney Diseases (3) · Liver Failure (3) · Male Urogenital Diseases (3) · Urogenital Diseases (3) · Urologic Diseases (3) · Liver Failure, Acute (2) · Brain Diseases (1)
Midodrine (3) · Albumins (2) · Octreotide (1) · Psychometrics (1) · dapagliflozin (1) · ornithylaspartate (1)
Post Graduate Institute of Medical Education and Research, Chandigarh (3) · Sequana Medical N.V. (2) · Air Force Military Medical University, China (1) · First People's Hospital of Foshan (1) · Mansoura University (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · Medical College of Wisconsin (1) · Medical University Innsbruck (1) · National Liver Institute, Egypt (1) · NovaShunt AG (1) · Tang-Du Hospital (1) · University of Alberta (1) · University of Arkansas (1)
Canada (3) · China (3) · India (2) · Spain (2) · Switzerland (2) · United States (2) · Austria (1) · Czechia (1) · Egypt (1) · Germany (1) · United Kingdom (1)
Amine Benmassaoud, MD (1) · Andrea De Gottardi, Privatdozent (1) · Andres Duarte-Rojo, MD, MSc (1) · Bassam Ayoub, MD (1) · Eric J Hohenwalter, MD (1) · Guohong Han, PhD & MD (1) · Pere Gines, MD (1) · Vincent Bain, MD, FRCPC (1) · Virendra Singh, MD, DM (1) · Yinong Ye, doctor (1)
PMID 28940225, PMID 29973706, PMID 31342529, PMID 35686702, PMID 37976391