8 recruiting, 3 completed, 3 unknown, 2 not yet recruiting. 4 Not applicable, 3 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Recruiting 2, Not yet recruiting 1, Terminated 1 |
| Early Phase 1 | 3 | Recruiting 3 |
Follow Puberty: new trials by email Literature Review of Puberty trials Research Report on Puberty
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Age of Puberty Onset Among Girls in Asyut, Egypt Puberty | Not yet recruiting | Assiut University | 600 | 2026-09-01 | 2026-08-19 | |
| Improving Health Among Disadvantaged Girls to Slow Pubertal Onset and Reduce Long-term Health Risks Family-Based Treatment (FBT) - Overweight/Obesity, Puberty | Not applicable | Not yet recruiting | University of Washington | 240 | 2026-05-01 | 2026-03-10 |
| ActiveGirls: Physical Activity, Hormone Health, and Diabetes Risk in Early Adolescence ActiveGirls Physical Activity Program (Full), ActiveGirls Physical Activity Program (Delayed Lower Intensity) - PCOS (Polycystic Ovary Syndrome), Puberty | Not applicable | Recruiting | Massachusetts General Hospital | 40 | 2025-11-24 | 2026-03-19 |
| Rejection Sensitivity and Puberty in Mental Health Vulnerability to Social Media Experiences in Early Adolescent Girls Social Rejection Task - Rejection Sensitivity, Puberty | Not applicable | Recruiting | Washington University School of Medicine | 250 | 2025-02-05 | 2026-05-06 |
| Spexin and Phoenixin-20 in Girls With Central Precocious Puberty Central Precocious Puberty (CPP), Puberty Disorders | Completed | Kayseri City Hospital | 143 | 2024-12-01 | 2026-01-22 | |
| Association of Acne Vulgaris With Oral Hygiene and Gingivitis Periodontal examination - Acne Vulgaris, Gingivitis | Unknown | Erzincan University | 60 | 2024-06-05 | 2024-05-28 | |
| Negative Emotionality and Epigenetics During Puberty Stress - Puberty, Healthy | Recruiting | International Research Training Group 2804 | 100 | 2024-03-26 | 2024-11-15 | |
| The 3rd COPENHAGEN Puberty Study Puberty, Puberty, Precocious | Recruiting | Copenhagen University Hospital, Rigshospitalet | 3000 | 2023-01-01 | 2024-01-10 | |
| Minipuberty of Infancy and the Timing of Pubertal Development in Adolescence: a Follow-up of the Infant Feeding and Early Development (IFED) Cohort Puberty | Enrolling by invitation | National Institute of Environmental Health Sciences (NIEHS) | 566 | 2022-10-10 | 2026-09-24 | |
| Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism? Spironolactone, Placebo - Hyperandrogenism, Polycystic Ovary Syndrome | Early Phase 1 | Recruiting | University of Virginia | 32 | 2021-11-12 | 2025-08-05 |
| Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study) Aminohippurate Sodium Inj 20%, Iohexol Inj 300 MG/ML, Dextran 40 - Type 2 Diabetes Mellitus, Diabetic Kidney Disease | Recruiting | Petter Bjornstad | 100 | 2021-09-27 | 2025-03-24 | |
| Skeletal Health and Bone Marrow Composition Among Youth GnRH Agonist - Gender Dysphoria in Children, Puberty | Not applicable | Terminated | Amy DiVasta, MD | 78 | 2020-09-15 | 2026-04-03 |
| Ovarian Morphology in Girls Amenorrhea, Oligomenorrhea | Unknown | Cornell University | 60 | 2020-01-31 | 2024-08-12 | |
| Hyperandrogenemia and Altered Day-night LH Pulse Patterns Micronized progesterone, Spironolactone, Placebo - Hyperandrogenism, Polycystic Ovary Syndrome | Early Phase 1 | Recruiting | University of Virginia | 32 | 2016-07-21 | 2025-08-05 |
| Investigating the Impact of Obesity on Pubertal Development in Girls Obesity, Puberty | Active not recruiting | National Institute of Environmental Health Sciences (NIEHS) | 93 | 2015-12-15 | 2026-11-10 | |
| Urinary DENND1A.V2 as a Predictor of Pubertal Hyperandrogenemia Phenotype/genotype assessment - Polycystic Ovary Syndrome, Hyperandrogenism | Suspended | University of Virginia | 65 | 2015-05-29 | 2023-11-02 | |
| Diet and Nutrition Pilot Study for Chinese Adolescents and Their Mothers Methylation, Body Composition | Completed | National Cancer Institute (NCI) | 278 | 2012-03-01 | 2020-03-03 | |
| Assessment of Day-night Secretion of Progesterone and LH Across Puberty Blood sampling - Puberty, Hyperandrogenism | Unknown | University of Virginia | 75 | 2008-07-10 | 2023-11-02 | |
| Acute Progesterone Suppression of Wake vs. Sleep Luteinizing Hormone Pulse Frequency in Pubertal Girls With and Without Hyperandrogenism Micronized progesterone suspension, Placebo - Puberty, Hyperandrogenism | Early Phase 1 | Recruiting | University of Virginia | 36 | 2008-06-01 | 2025-08-05 |
| The COPENHAGEN Puberty Study Puberty | Completed | Copenhagen University Hospital, Rigshospitalet | 1957 | 2006-07-01 | 2019-10-10 |
Hyperandrogenism (5) · Polycystic Ovary Syndrome (5) · Motor Activity (2) · Obesity (2) · Puberty, Precocious (2) · Acne Vulgaris (1) · Amenorrhea (1) · Dental Plaque (1) · Diabetes Mellitus, Type 2 (1) · Diabetic Nephropathies (1) · Gingivitis (1) · Glucose Intolerance (1) · Health Behavior (1) · Insulin Resistance (1) · Oligomenorrhea (1)
Endocrine System Diseases (9) · Gonadal Disorders (8) · Female Urogenital Diseases (7) · Female Urogenital Diseases and Pregnancy Complications (7) · Urogenital Diseases (7) · Male Urogenital Diseases (6) · 46, XX Disorders of Sex Development (5) · Adnexal Diseases (5) · Adrenogenital Syndrome (5) · Congenital Abnormalities (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Cysts (5) · Disorders of Sex Development (5) · Genital Diseases (5) · Genital Diseases, Female (5)
Progesterone (2) · Spironolactone (2) · Blood Specimen Collection (1) · Dextrans (1) · Iohexol (1) · Phenotype (1) · p-Aminohippuric Acid (1)
University of Virginia (5) · Copenhagen University Hospital, Rigshospitalet (2) · National Institute of Environmental Health Sciences (NIEHS) (2) · Amy DiVasta, MD (1) · Assiut University (1) · Cornell University (1) · Erzincan University (1) · International Research Training Group 2804 (1) · Kayseri City Hospital (1) · Massachusetts General Hospital (1) · National Cancer Institute (NCI) (1) · Petter Bjornstad (1) · University of Washington (1) · Washington University School of Medicine (1)
United States (13) · Denmark (2) · China (1) · Germany (1) · Turkey (Türkiye) (1)
Anders Juul, PhD, DMSc (2) · Christine Burt Solorzano, M.D. (1) · Christine Burt Solorzano, MD (1) · Christine M Burt Solorzano, MD (1) · Christopher McCartney, MD (1) · Christopher R. McCartney, MD (1) · Dale P Sandler, Ph.D. (1) · Kathleen Hoeger, MD (1) · Maria Bleil, PhD (1) · Marla E Lujan, PhD (1) · Mirac Nur Musaoglu, MD (1) · Nancy A. Potischman, Ph.D. (1) · Natalie D Shaw, M.D. (1) · Petter Bjornstad, MD (1) · Romina Barral, MD MSCR FAPP (1)
PMID 19088161, PMID 19196890, PMID 19403485, PMID 19417039, PMID 19926714, PMID 20382688, PMID 20484471, PMID 20719830, PMID 20843948, PMID 21251056, PMID 21346077, PMID 22215627, PMID 22428786, PMID 22612475, PMID 22901847, PMID 23013046, PMID 23093700, PMID 23393169, PMID 23491025, PMID 23548728, PMID 24883065, PMID 27057785, PMID 27349168, PMID 28009526, PMID 28323923, PMID 28938419, PMID 29077908, PMID 29300925, PMID 31348498, PMID 31761939, PMID 32761207, PMID 33630047, PMID 34156716, PMID 39292994, PMID 40974100, PMID 41693548, PMID 41921573, PMID 41965607, PMID 42001254
P50HD028934 (3), K23DK131322 (1), R01DK142759 (1), R01HD102060 (1), R01MH135480 (1)