12 completed, 3 unknown, 1 recruiting, 1 withdrawn. 17 Phase 2, 4 Phase 1, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 17 | Completed 12, Unknown 3, Recruiting 1, Withdrawn 1 |
| Phase 1 | 4 | Completed 2, Unknown 2 |
| Phase 3 | 3 | Completed 2, Unknown 1 |
Follow Prolapse: new trials by email Literature Review of Prolapse trials Research Report on Prolapse
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Transvaginal Human Acellular Dermal Matrix for Prolapse Treatment Vaginal hysterectomy plus matrix reinforcement and sacrospinous fixation with Anchorsure® device, Vaginal hysterectomy plus anterior colporrhaphy, Vaginal hysterectomy plus sacrospinous fixation with Anchorsure® device - Prolapse; Female, Prolapse Genital | Phase 2 | Recruiting | Hospital Mutua de Terrassa | 90 | 2024-07-01 | 2025-01-17 |
| Materna Prep Study Phase II Materna Prep Device - Vaginal Delivery, Pelvic Organ Prolapse | Phase 2 | Completed | Materna Medical | 214 | 2021-09-08 | 2024-02-05 |
| Flat Polypropylene Mesh in the Treatment of Uterine and Recurrent or Advanced Pelvic Organ Prolapse Restorelle® Flat Mesh - Pelvic Organ Prolapse | Phase 1 / Phase 2 | Unknown | Michigan Institution of Women's Health PC | 30 | 2021-09-01 | 2024-01-25 |
| Gentamicin Intravesical Efficacy for Infection of Urinary Tract gentamicin sulfate, Catheter clamping only - Postoperative Urinary Tract Infection, Pelvic Organ Prolapse | Phase 2 | Completed | Kaiser Permanente | 370 | 2020-01-29 | 2022-11-08 |
| Urinary Track Infection Prevention After Urogynecological Surgery Methenamine Hippurate 1 g tablet, Placebo tablet - Urinary Tract Infections, Urinary Retention Postoperative | Phase 2 | Completed | TriHealth Inc. | 185 | 2019-06-17 | 2022-11-14 |
| Tamsulosin vs Placebo to Prevent Postoperative Urinary Retention in Female Pelvic Reconstructive Surgery Placebo oral capsule, Tamsulosin - Urinary Retention, Lower Urinary Tract Symptoms | Phase 2 / Phase 3 | Completed | University Hospitals Cleveland Medical Center | 132 | 2018-08-01 | 2021-11-08 |
| Preoperative Levator Ani Muscle Injection and Pudendal Nerve Block for Pain Control After Vaginal Reconstructive Surgery Dexamethasone, Bupivacaine, Bilateral Pudendal Nerve Block - Pelvic Organ Prolapse, Surgery | Phase 1 / Phase 2 | Completed | Lauren Giugale, MD | 79 | 2017-06-01 | 2020-03-09 |
| Dexamethasone Administration To Improve Patient Recovery In Ambulatory Vaginal Prolapse Surgery: Is There A Role? Dexamethasone, Normal saline - Quality of Recovery, Same Day Surgery | Phase 2 | Completed | The Cleveland Clinic | 51 | 2017-05-01 | 2021-04-14 |
| Pudendal Nerve Block for Postoperative Posterior Repair Pain Relief Pudendal Nerve Block - Pelvic Organ Prolapse | Phase 2 | Completed | Royal Devon and Exeter NHS Foundation Trust | 21 | 2015-08-01 | 2018-04-11 |
| Vaginal Creams to Reduce Vaginal Erosion in Pessary Users Estradiol, placebo - Atrophy of Vagina, Vaginal Ulceration | Phase 2 | Withdrawn | Northwell Health | 2015-04-01 | 2015-10-02 | |
| Clinical and Urodynamic Evaluation of Surgical Repair of Pelvic Organ Prolapse Associated With Lower Urinary Tract Symptoms Urodynamic study - Pelvic Organ Prolapse | Phase 2 | Completed | Ain Shams University | 83 | 2014-12-01 | 2021-03-11 |
| Randomized Controlled Trial of Cystocele Plication Risks ("CPR Trial"): A Pilot Study Cystocele plication, No Plication - Voiding Dysfunction | Phase 2 | Completed | Mount Sinai Hospital, Canada | 40 | 2009-02-01 | 2016-12-20 |
| Outcomes Following Vaginal Prolapse Repair and Mid Urethral Sling Trial TVT, Sham - Pelvic Organ Prolapse | Phase 2 | Completed | NICHD Pelvic Floor Disorders Network | 337 | 2007-05-01 | 2018-05-30 |
| Post-Operative Pain Control Using Direct Continuous Bupivacaine Infusion After Pelvic Organ Prolapse Repair Continuous bupivacaine analgesia infusion (ON-Q PainBuster Post-Op Pain Relief System) - Post-Operative Pain, Pelvic Organ Prolapse | Phase 2 / Phase 3 | Unknown | St. Luke's Hospital, Kansas City, Missouri | 80 | 2007-04-01 | 2008-06-11 |
| Safety Study of Pelvic Organ Prolapse Repair Using Transvaginal Mesh Transvaginal mesh- PROLIFT®-system - Pelvic Organ Prolapse | Phase 2 / Phase 3 | Completed | Karolinska Institutet | 250 | 2006-08-01 | 2007-11-14 |
| Anterior Vaginal Wall Reconstruction tvt-o operation, tvt o operation - Vaginal Prolapse | Phase 1 / Phase 2 | Unknown | Hippocration General Hospital | 50 | 2005-01-01 | 2007-12-12 |
| Does Doing Pelvic Floor Exercise Ease Symptoms for Women Living With Prolapse? pelvic floor muscle training - Uterine Prolapse | Phase 1 / Phase 2 | Completed | Glasgow Caledonian University | 50 | 2003-09-01 | 2015-03-19 |
Pelvic Organ Prolapse (13) · Uterine Prolapse (3) · Cystocele (2) · Pain, Postoperative (2) · Urinary Incontinence (2) · Urinary Incontinence, Stress (2) · Agnosia (1) · Lower Urinary Tract Symptoms (1) · Postoperative Nausea and Vomiting (1) · Urinary Retention (1) · Urinary Tract Infections (1) · Vaginitis (1)
Pathological Conditions, Anatomical (17) · Pathological Conditions, Signs and Symptoms (17) · Female Urogenital Diseases (9) · Female Urogenital Diseases and Pregnancy Complications (9) · Urogenital Diseases (9) · Signs and Symptoms (7) · Male Urogenital Diseases (6) · Urologic Diseases (6) · Genital Diseases (4) · Genital Diseases, Female (4) · Urination Disorders (4) · Urological Manifestations (4) · Lower Urinary Tract Symptoms (3) · Pathologic Processes (3)
Dexamethasone (2) · Saline Solution (2) · Bupivacaine (1) · Calcium Dobesilate (1) · Estradiol (1) · Gentamicins (1) · Hysterectomy, Vaginal (1) · Sodium Chloride (1) · Tablets (1) · Tamsulosin (1) · Vaginal Creams, Foams, and Jellies (1) · methenamine hippurate (1) · salicylhydroxamic acid (1)
Ain Shams University (1) · Glasgow Caledonian University (1) · Hippocration General Hospital (1) · Hospital Mutua de Terrassa (1) · Kaiser Permanente (1) · Karolinska Institutet (1) · Lauren Giugale, MD (1) · Materna Medical (1) · Michigan Institution of Women's Health PC (1) · Mount Sinai Hospital, Canada (1) · NICHD Pelvic Floor Disorders Network (1) · Northwell Health (1) · Royal Devon and Exeter NHS Foundation Trust (1) · St. Luke's Hospital, Kansas City, Missouri (1) · The Cleveland Clinic (1)
United States (10) · United Kingdom (2) · Denmark (1) · Finland (1) · Greece (1) · Norway (1) · Spain (1) · Sweden (1)
Daniel Altman, MD, PhD (1) · Danny Lovatsis, MD (1) · G. Willy Davila (1) · Graham Chapman (1) · John T Wei, MD (1) · Kimberly L Ferrante, M.D., M.A.S. (1) · Lauren Giugale, MD (1) · Lawrence Lind, MD (1) · Marianna Alperin, M.D., M.S. (1) · Rachel Pauls, MD (1) · Salil Khandwala, MD (1) · Suzanne Hagen (1)
PMID 18074068, PMID 19104367, PMID 19104368, PMID 22517125, PMID 32769645, PMID 33278291, PMID 33894146, PMID 35272334, PMID 36409639, PMID 41649019
U01HD041249 (1), U10HD041250 (1), U10HD041261 (1), U10HD041267 (1), U10HD054136 (1), U10HD054214 (1), U10HD054215 (1), U10HD054241 (1)