365 completed, 141 unknown, 47 recruiting, 30 active not recruiting. 346 Not applicable, 44 Phase 4, 21 Phase 3, 16 Phase 2, 5 Phase 1.
Follow Pelvic Organ Prolapse: new trials by email Literature Review of Pelvic Organ Prolapse trials Research Report on Pelvic Organ Prolapse
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Suzetrigine for Opioid-Sparing Postoperative Analgesia Following Transvaginal Pelvic Reconstructive Surgery Suzetrigine, Opioid Analgesics (Tramadol or Oxycodone), Scheduled Acetaminophen and Ibuprofen - Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI) | Phase 4 | Not yet recruiting | University of California, Los Angeles | 120 | 2026-11-01 | 2026-09-15 |
| Suzetrigine Following Urogynecologic Surgery: Investigation of Postoperative Pain Management Suzetrigine, Placebo - Pelvic Organ Prolapse (POP), Postoperative Pain | Phase 4 | Not yet recruiting | Aditi Talkad | 48 | 2026-11-01 | 2026-10-02 |
| Improving Uroflowmetry Interpretability: Evaluating the Impact of Patient Reminder Systems Patient reminder system - Pelvic Organ Prolapse, Urinary Incontinence | Not applicable | Recruiting | Ohio State University | 162 | 2026-11-01 | 2026-09-24 |
| Perineal Protection Device for Reducing Perineal Trauma During Vaginal Delivery in First-time Mothers: a Multicenter Randomized Controlled Trial Perineal protection device, BabySlide, Standard manual perineal support - Pelvic Floor Dysfunction, Perineal Laceration | Not applicable | Not yet recruiting | Region Skane | 4226 | 2026-10-05 | 2026-10-07 |
| How Low Can You Go Standard insufflation, Low insufflation - Pelvic Organ Prolapse | Not applicable | Not yet recruiting | University of Calgary | 164 | 2026-09-01 | 2026-08-26 |
| Poly-L-Lactic Acid for Vulvovaginal Tissue Regeneration Poly-L-Lactic Acid (Sculptra) injection, Placebo injection (sterile water) - Pelvic Organ Prolapse (POP), Cystocele | Not applicable | Recruiting | Cassandra Kisby | 20 | 2026-08-20 | 2026-08-21 |
| Urinary Continence After Vaginal Surgery for Genital Prolapse in the Spanish Population. Vaginal surgery for pelvic organ prolapse - Pelvic Organ Prolapse (POP), Pelvic Organ Prolapse Vaginal Surgery | Not yet recruiting | Hospital Universitari Vall d'Hebron Research Institute | 1042 | 2026-08-01 | 2026-06-04 | |
| Deep Neuromuscular Blockade and a Low-Residue Diet for the Surgical Field in vNOTES Hysterectomy Deep Neuromuscular Blockade (NMB), Standard (moderate) neuromuscular blockade, Preoperative low-residue diet - Leiomyoma, Uterine, Benign Gynecological Disease | Not applicable | Recruiting | Fatih Sultan Mehmet Training and Research Hospital | 160 | 2026-07-01 | 2026-07-30 |
| Centered Surgery - Preoperative Counseling and Patient Satisfaction Pelvic Organ Prolapse | Recruiting | The Cleveland Clinic | 106 | 2026-06-11 | 2026-08-03 | |
| Vaginal Vault Native Tissue Suspension Mackenrodt uterosacral double ligaments suspension - Pelvic Organ Prolapse | Not applicable | Recruiting | Assiut University | 10 | 2026-06-03 | 2026-06-04 |
| The Finnish Uterine Prolapse Surgery Trial (The Fin-UP Trial) Manchester procedure, Vaginal hysterectomy - Uterine Prolapse, Pelvic Organ Prolapse Vaginal Surgery | Not applicable | Recruiting | Tampere University Hospital | 426 | 2026-05-01 | 2026-05-11 |
| Evaluation of a Personalizable Pessary for Pelvic Organ Prolapse Novel Personalizable Pessary - Pelvic Organ Prolapse (POP) | Not applicable | Recruiting | University of Alberta | 43 | 2026-04-30 | 2026-06-04 |
| Safety and Performance of a Pelvic Floor Mesh Implant for Laparoscopic Sacrocolpopexy (ProGYNious) Surgical mesh for pelvic organ prolapse repair (ProGYNious) - Pelvic Organ Prolapse (POP), Synthetic Mesh | Not applicable | Not yet recruiting | A.M.I. Agency for Medical Innovations GmbH | 100 | 2026-04-15 | 2026-03-27 |
| The RECOVER Study - Postpartum Recovery of Pelvic Floor Structures and the Impact of Early Rehabilitation Early individualized pelvic floor muscle training (PFMT) - Urinary Incontinence, Pelvic Organ Prolapse (POP) | Not applicable | Recruiting | Vastra Gotaland Region | 380 | 2026-04-07 | 2026-05-27 |
| Effect of Paracervical Block on Postoperative Pain After vNOTES Uterosacral Ligament Suspension Bupivacaine, Normal Saline - Pelvic Organ Prolapse (POP), Postoperative Pain | Not applicable | Recruiting | Erkan Gol | 58 | 2026-03-09 | 2026-03-11 |
| Vaginal Estrogen for Improvement of Outcomes Following Pelvic Organ Prolapse Surgery Vaginal Estrogen - Twice Weekly, Vaginal Estrogen - Daily - Pelvic Organ Prolapse (POP) | Phase 3 | Recruiting | Sarah Wozney | 180 | 2026-01-01 | 2026-08-20 |
| The Assessment of Fibrin Clot Phenotype and Thrombin Generation in Women After Urogynecological Surgeries. determination of fibrin clot properties - Uterine Prolapse, Urine Incontinence | Recruiting | Jagiellonian University | 60 | 2025-12-10 | 2025-12-22 | |
| RUG-WEAVING PLICATION IN CYSTOCELE TREATMENT rug weaving-like plication technique, group 2:conventional technique cystocele treatment - Cystocele | Completed | Ankara City Hospital Bilkent | 60 | 2025-12-01 | 2026-01-13 | |
| Barriers and Enablers to Accessing Medical Care for Urinary Incontinence and Prolapse in GLobal Majority Women No intervention - Pelvic Prolapse Conditions | Not yet recruiting | Manchester University NHS Foundation Trust | 160 | 2025-12-01 | 2025-12-30 | |
| Safety and Performance of a Pelvic Floor Mesh Implant (LatGYNious) Laparoscopic lateral suspension with surgical mesh (LatGYNious) - Pelvic Organ Prolapse (POP), Genital Prolapse | Not applicable | Recruiting | A.M.I. Agency for Medical Innovations GmbH | 85 | 2025-11-01 | 2026-07-28 |
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Uterine Prolapse (107) · Cystocele (70) · Urinary Incontinence (64) · Rectal Prolapse (52) · Prolapse (49) · Urinary Incontinence, Stress (47) · Rectocele (31) · Pelvic Floor Disorders (27) · Pain, Postoperative (16) · Hernia (15) · Sexual Dysfunction, Physiological (15) · Urinary Bladder, Overactive (12) · Fecal Incontinence (11) · Urinary Retention (11)
Pathological Conditions, Signs and Symptoms (650) · Pathological Conditions, Anatomical (648) · Prolapse (601) · Urogenital Diseases (269) · Female Urogenital Diseases and Pregnancy Complications (266) · Female Urogenital Diseases (264) · Male Urogenital Diseases (191) · Urologic Diseases (178) · Signs and Symptoms (144) · Genital Diseases (134) · Genital Diseases, Female (117) · Urological Manifestations (116) · Urination Disorders (112) · Uterine Diseases (112)
Bupivacaine (7) · Laparoscopy (7) · Saline Solution (7) · Melanocyte-Stimulating Hormones (6) · Surveys and Questionnaires (6) · Restraint, Physical (5) · Sodium Chloride (5) · Dexamethasone (4) · Hysterectomy (4) · Hysterectomy, Vaginal (4) · Laser Therapy (4) · Pessaries (4) · Sutures (4) · Estrogens, Conjugated (USP) (3) · Gabapentin (3)
National Taiwan University Hospital (17) · TriHealth Inc. (15) · Peking Union Medical College Hospital (14) · Atlantic Health System (13) · The Cleveland Clinic (12) · Centre Hospitalier Universitaire de Nīmes (11) · Gaziosmanpasa Research and Education Hospital (8) · Ethicon, Inc. (7) · University of North Carolina, Chapel Hill (7) · Ain Shams Maternity Hospital (6) · Assiut University (6) · Hartford Hospital (6) · Kaiser Permanente (6) · Kanuni Sultan Suleyman Training and Research Hospital (6) · NICHD Pelvic Floor Disorders Network (6)
United States (223) · Turkey (Türkiye) (44) · France (35) · China (29) · Taiwan (24) · Egypt (22) · Germany (22) · Italy (19) · Canada (18) · United Kingdom (18) · Belgium (14) · Denmark (14) · Israel (12) · Netherlands (11) · Switzerland (10)
Lan Zhu (7) · Lan Zhu, MD (7) · Rachel Pauls, MD (6) · Ho-Hsiung Lin, PhD (5) · Patrick Culligan, MD (5) · Dimitri Sarlos, MD (4) · Brigitte Fatton, MD (3) · David Robinson, MD (3) · Dmitry Shkarupa, MD, PhD (3) · Ho-Hsiung Lin, MD, PhD (3) · Kris Strohbehn, MD (3) · Martin Weisberg, MD (3) · Roy Lauterbach, MD (3) · Andrea Morciano, M.D. (2) · Ann Tran, MD (2)
PMID 19941278, PMID 34184246, PMID 37431855, PMID 26337427, PMID 26573101, PMID 26634203, PMID 28754926, PMID 32769645, PMID 33207004, PMID 19937315, PMID 21344495, PMID 22517125, PMID 24118844, PMID 25421934, PMID 29472143, PMID 29692690, PMID 33030871, PMID 33388056, PMID 37888839, PMID 38477494, PMID 41649019, PMID 42029168, PMID 10413222, PMID 10522604, PMID 10562780, PMID 11795640, PMID 12790869, PMID 12811491, PMID 14664880, PMID 14751349, PMID 14756739, PMID 15227649, PMID 1547052, PMID 15499644, PMID 15767530, PMID 15915320, PMID 15989095, PMID 16141767, PMID 16220584, PMID 16282227, PMID 16611949, PMID 16897749, PMID 17031741, PMID 17049716, PMID 17336819, PMID 17370026, PMID 17513926, PMID 17618768, PMID 17636742, PMID 17645604
U10HD041261 (6), U10HD041267 (6), U10HD041250 (5), U01HD041249 (4), U10HD041263 (4), U10HD041248 (3), U10HD041268 (3), U10HD054214 (3), U10HD054215 (3), 2019 (2), R43AG034714 (2), U10HD041269 (2), U10HD054136 (2), U10HD054241 (2), K12AR084231 (1)