4 completed, 3 recruiting, 3 terminated, 2 withdrawn. 5 Phase 4, 4 Not applicable, 2 Early Phase 1, 2 Phase 2.
Follow methenamine hippurate: new trials by email Literature Review of methenamine hippurate trials Research Report on methenamine hippurate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vitamin C and Hiprex in rUTI Methenamine Hippurate 1g BD, Methenamine Hippurate 1g BD + Vitamin C 1g BD - Urinary Tract Infections | Early Phase 1 | Not yet recruiting | University Hospitals of North Midlands NHS Trust | 20 | 2027-01-01 | 2026-02-11 |
| A Clinical Trial of Extended (High) Treatment Dose Antibiotics in Combination With Methenamine Hippurate Compared to the Standard of Care (Either Prophylactic (Low) Dose Antibiotic Treatment or Methenamine Hippurate) in Females With Chronic Urinary Tract Infection Treatment dose antibiotic in combination with methenamine hippurate, Prophylactic dose antibiotic or methenamine hippurate monotherapy - Chronic Urinary Tract Infection | Phase 2 | Recruiting | University College, London | 192 | 2026-02-26 | 2026-10-14 |
| Methenamine Hippurate Following Intradetrusor OnabotulinumtoxinA Injection Methenamine Hippurate, Typically prescribed oral antibiotic prophylaxis - Overactive Bladder (OAB), Urinary Tract Infection (Diagnosis) | Phase 4 | Recruiting | Women and Infants Hospital of Rhode Island | 164 | 2025-08-01 | 2026-08-19 |
| Is Methenamine Prophylaxis for Urinary Tract Infection After Midurethral Sling as Effective as Antibiotic Prophylaxis? Methenamine Hippurate 1g BD, Antibiotic prophylaxis - Urinary Tract Infection (Diagnosis) | Not applicable | Recruiting | Atlantic Health System | 190 | 2025-01-30 | 2025-02-07 |
| The Efficacy of Orally Administrated Probiotic Formula in Preventing a Recurrence of a Urinary Tract Infection During Pregnancy Urex Plus - containing L. rhamnosus GR-1 and L. reuteri RC-14, Placebo - capsule with no active ingredient - Urinary Tract Infections (UTIs) | Not applicable | Withdrawn | HaEmek Medical Center, Israel | 2022-11-07 | 2022-11-08 | |
| Efficacy and Mechanism of Action of Methenamine Hippurate (Hiprex™) in Women With Recurring Urinary Tract Infections. Hiprex - Urinary Tract Infections | Phase 4 | Terminated | University of Texas Southwestern Medical Center | 14 | 2021-01-04 | 2026-02-24 |
| The Effect of Methenamine Hippurate to Reduce Antibiotic Prescribing in Elderly Women With Recurrent UTI Methenamine Hippurate 1000 MG - Recurrent Urinary Tract Infection | Phase 4 | Completed | University of Oslo | 289 | 2019-11-01 | 2024-09-03 |
| Urinary Track Infection Prevention After Urogynecological Surgery Methenamine Hippurate 1 g tablet, Placebo tablet - Urinary Tract Infections, Urinary Retention Postoperative | Phase 2 | Completed | TriHealth Inc. | 185 | 2019-06-17 | 2022-11-14 |
| Methenamine in a Non-antibiotic, Multimodal Approach to UTI Prevention Methenamine Hippurate 1000 MG, Vaginal estrogen, D-mannose - UTI, Female Urogenital Diseases | Phase 4 | Withdrawn | Washington University School of Medicine | 2018-06-20 | 2022-07-08 | |
| Methenamine Hippurate Versus Trimethoprim in the Prevention of Recurrent UTIs Trimethoprim, Methenamine hippurate - Urinary Tract Infections, Recurrent | Phase 4 | Completed | Endeavor Health | 92 | 2016-06-01 | 2020-01-14 |
| The Association Between the Transfer of Lactobacilli From the Gastrointestinal Tract to the Vagina and the Prevention / Eradication of Abnormal Vaginal Flora in High Risk Pregnancies Urex Plus, Placebo, Probotic capsule containing L. rhamnosus GR-1and L. reuteri RC-14 - Pregnancy | Not applicable | Terminated | HaEmek Medical Center, Israel | 40 | 2016-01-01 | 2019-12-17 |
| Short-course Methenamine Hippurate for Prevention of Post-operative UTI methenamine hippurate, Ciprofloxacin - Urinary Tract Infections, Catheter-Related Infections | Not applicable | Completed | University of Pennsylvania | 201 | 2014-12-01 | 2022-02-25 |
| Patients Response to Early Switch To Oral:Osteomyelitis Study oral antibiotics, intravenous antibiotics - Osteomyelitis | Early Phase 1 | Terminated | Julio Ramirez | 11 | 2014-03-06 | 2021-04-06 |
Urinary Tract Infections (11) · Disease (2) · Catheter-Related Infections (1) · Female Urogenital Diseases (1) · Osteomyelitis (1) · Pelvic Organ Prolapse (1) · Urinary Bladder, Overactive (1) · Urologic Diseases (1)
HaEmek Medical Center, Israel (2) · Atlantic Health System (1) · Endeavor Health (1) · Julio Ramirez (1) · TriHealth Inc. (1) · University College, London (1) · University Hospitals of North Midlands NHS Trust (1) · University of Oslo (1) · University of Pennsylvania (1) · University of Texas Southwestern Medical Center (1) · Washington University School of Medicine (1) · Women and Infants Hospital of Rhode Island (1)
United States (7) · United Kingdom (2) · Israel (1) · Netherlands (1) · Norway (1) · Poland (1) · Sweden (1)
Cees Hertogh, prof.MD (1) · Christine Chu, MD (1) · Christine M Chu, MD (1) · Daniel Lee, MD (1) · David Seligson, MD (1) · Enav Yefet, MD/PhD (1) · Julio Ramirez, MD (1) · Lily Arya, MD, MS (1) · Maciek Godycki.Cwirko, prof MD (1) · Per-Daniel Sundvall, MD PhD (1) · Philippe Zimmern, MD (1) · Rachel Pauls, MD (1) · Theo Verheij, prof. MD (1) · Vivian Sung, MD, MPH (1)
PMID 15276398, PMID 15840453, PMID 19588358, PMID 22530208, PMID 22575772, PMID 23076896, PMID 25410372, PMID 26108340, PMID 28272565, PMID 28493770, PMID 29170359, PMID 3111615, PMID 35272334, PMID 36041061, PMID 36319057, PMID 40669691, PMID 4902833, PMID 6227756, PMID 8948280