42 completed, 15 unknown, 5 withdrawn, 4 recruiting. 23 Phase 2, 15 Phase 3, 11 Phase 1, 8 Not applicable, 5 Phase 4.
Follow Primary Biliary Cirrhosis: new trials by email Literature Review of Primary Biliary Cirrhosis trials Research Report on Primary Biliary Cirrhosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| TruGraf Liver Gene Expression Serial Test TruGraf® - Autoimmune Liver Disease, Autoimmune Hepatitis | Terminated | Washington University School of Medicine | 13 | 2024-08-01 | 2026-08-07 | |
| Liver-gut Axis Study Through Identification of Liver Disease-specific Microbiome Autoimmune Hepatitis, Primary Sclerosing Cholangitis | Recruiting | Chungnam National University Hospital | 3000 | 2024-07-08 | 2026-03-20 | |
| Mind-body Wellness Intervention in Primary Biliary Cholangitis (PBC) Mind-body intervention with 1-1 support from study personnel - Primary Biliary Cirrhosis | Not applicable | Completed | University of Alberta | 87 | 2021-10-03 | 2022-08-03 |
| Study of Obeticholic Acid（OCA） Combination With Ursodeoxycholic Acid (UDCA) in Patients With Primay Biliary Cirrhosis (PBC) Obeticholic Acid Tablets, UDCA, Placebo - Primary Biliary Cirrhosis | Phase 3 | Unknown | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 120 | 2021-07-22 | 2021-07-26 |
| A Randomised Clinical Trial Assessing the Efficacy and Safety of Mycophenolate Mofetil Versus Azathioprine for Induction of Remission in Treatment Primary Biliary Cholangitis-Autoimmune Hepatitis Overlap Syndrome Methylprednisolone and Mycophenolate mofetil, Methylprednisolone and azathioprine - Autoimmune Hepatitis, Primary Biliary Cirrhosis | Phase 4 | Unknown | Xiaoli Fan | 78 | 2021-06-16 | 2021-06-21 |
| Open-Label Study of HTD1801 in Adult Subjects With Primary Biliary Cholangitis HTD1801 (BUDCA) - Primary Biliary Cholangitis, Primary Biliary Cirrhosis | Phase 2 | Completed | HighTide Therapeutics (Hong Kong) Limited | 24 | 2021-05-27 | 2026-08-25 |
| PBC Induced Fatigue Treated With Thiamine Thiamine, Placebo - Primary Biliary Cirrhosis | Phase 4 | Unknown | Henning Grønbæk | 36 | 2021-05-12 | 2021-05-20 |
| Online Wellness Intervention for Primary Biliary Cholangitis (PBC) Mind-body therapy - Primary Biliary Cirrhosis | Not applicable | Completed | University of Alberta | 34 | 2021-02-14 | 2024-01-18 |
| A Study to Assess Efficacy and Safety of Bezafibrate in Patients With Primary Biliary Cholangitis Bezafibrate 200 MG Oral Tablet, Placebo, Ursodeoxycholic Acid - Primary Biliary Cirrhosis | Phase 3 | Unknown | Instituto Mexicano del Seguro Social | 11 | 2020-10-02 | 2021-02-12 |
| Bezafibrate in Patients With Primary Biliary Cholangitis (PBC) Blood sampling, Fibroscan, Question - Primary Biliary Cirrhosis | Unknown | University of Aarhus | 100 | 2020-10-01 | 2022-08-12 | |
| Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC) Elafibranor 80mg, Placebo - Primary Biliary Cirrhosis | Phase 3 | Active not recruiting | Ipsen | 161 | 2020-09-24 | 2026-10-21 |
| A Study of TQA3526 in the Treatment of Primary Biliary Cirrhosis (PBC) TQA3526, Placebo to match TQA3526 - Primary Biliary Cirrhosis | Phase 2 | Unknown | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 130 | 2020-03-20 | 2020-02-20 |
| Umbilical Cord Derived Mesenchymal Stem Cell (UC -MSC) Transplantation for Children Suffering From Biliary Atresia Umbilical Cord Derived Mesenchymal Stem Cell (UC -MSC) Transplantation - Primary Biliary Cirrhosis | Phase 1 / Phase 2 | Completed | Vinmec Research Institute of Stem Cell and Gene Technology | 20 | 2019-08-10 | 2024-06-06 |
| Gut Microbes and Metabolic Group in Different PBC Patients for UDCA Response total response Group - Primary Biliary Cirrhosis | Completed | Sun Yat-sen University | 60 | 2018-08-22 | 2019-12-24 | |
| Repeatability and Reproducibility of Quantitative MRCP MRCP+ - Primary Sclerosing Cholangitis, Primary Biliary Cirrhosis | Completed | Perspectum | 40 | 2018-07-19 | 2019-08-28 | |
| Clinical Trial on the Effect of the Sublimated Mare Milk Supplement on Primary Biliary Cholangitis Sublimated mare milk, Ursodeoxycholic Acid - Primary Biliary Cirrhosis | Not applicable | Completed | National Scientific Medical Center, Kazakhstan | 40 | 2018-01-03 | 2021-01-26 |
| Study of Seladelpar in Participants With Primary Biliary Cholangitis (PBC) Seladelpar 5 mg Capsule, Seladelpar 10 mg Capsule - Primary Biliary Cirrhosis | Phase 3 | Active not recruiting | Gilead Sciences | 340 | 2017-12-12 | 2026-05-04 |
| Mesenchymal Stem Cell Transplantation for Refractory Primary Biliary Cholangitis mesenchymal stem cell transplantation or placebo infusion via peripheral vein - Primary Biliary Cirrhosis | Not applicable | Unknown | Xijing Hospital of Digestive Diseases | 140 | 2017-11-08 | 2018-09-12 |
| Study to Evaluate Safety, Tolerability and Efficacy of Saroglitazar Mg in Patients With Primary Biliary Cholangitis Saroglitazar magnesium 2 mg, Saroglitazar magnesium 4 mg, Placebo Oral Tablet - Primary Biliary Cirrhosis | Phase 2 | Completed | Zydus Therapeutics Inc. | 37 | 2017-08-18 | 2024-09-19 |
| Study to Assess Safety & Efficacy of GKT137831 in Patients With Primary Biliary Cholangitis Receiving Ursodiol. GKT137831, Placebo oral capsule - Primary Biliary Cirrhosis | Phase 2 | Completed | Calliditas Therapeutics AB | 111 | 2017-06-26 | 2022-06-29 |
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Liver Cirrhosis, Biliary (73) · Cholangitis, Sclerosing (7) · Hepatitis, Autoimmune (6) · Cholestasis (4) · Alagille Syndrome (3) · Fatigue (3) · Liver Diseases (3) · Addison Disease (2) · Biliary Atresia (2) · Cholestasis, progressive familial intrahepatic 1 (2) · Fibrosis (2) · Hepatitis (2) · Myasthenia Gravis (2) · Non-alcoholic Fatty Liver Disease (2) · 3-Methylglutaconic Aciduria, Type V (1)
Bile Duct Diseases (73) · Cholestasis, Intrahepatic (73) · Digestive System Diseases (73) · Pathologic Processes (73) · Pathological Conditions, Signs and Symptoms (73) · Biliary Tract Diseases (72) · Liver Cirrhosis (72) · Fibrosis (71) · Liver Diseases (70) · Cholestasis (69) · Autoimmune Diseases (7) · Cholangitis (7) · Immune System Diseases (7) · Hepatitis (6) · Hepatitis, Chronic (6)
Ursodeoxycholic Acid (9) · Fenofibrate (4) · obeticholic acid (4) · Blood Specimen Collection (3) · (2-methyl-4-(5-methyl-2-(4-trifluoromethyl-phenyl)-2H-(1,2,3)triazol-4-ylmethylsulfanyl)phenoxy)acetic acid (2) · Bezafibrate (2) · Budesonide (2) · Multiparametric Magnetic Resonance Imaging (2) · Rituximab (2) · Surveys and Questionnaires (2) · Tablets (2) · aldafermin (2) · seladelpar (2) · 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid (1) · Abatacept (1)
Mayo Clinic (6) · University of Aarhus (5) · Xijing Hospital of Digestive Diseases (5) · University of Alberta (4) · Albireo (2) · Beijing 302 Hospital (2) · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (2) · Dr. Falk Pharma GmbH (2) · Gilead Sciences (2) · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (2) · Intercept Pharmaceuticals (2) · Mirum Pharmaceuticals, Inc. (2) · NGM Biopharmaceuticals, Inc (2) · Perspectum (2) · University of California, Davis (2)
United States (28) · United Kingdom (15) · China (13) · Canada (11) · Germany (7) · Denmark (6) · Australia (5) · Italy (5) · Belgium (4) · France (4) · Mexico (4) · Netherlands (4) · Spain (4) · Austria (3) · Poland (3)
Christopher L Bowlus, MD (3) · Cynthia Levy, MD (2) · Keith D Lindor, MD (2) · M. Eric Gershwin, MD (2) · Puneeta Tandon (2) · Stephen J Rossi, PharmD (2) · Adrian DiBisceglie, MD (1) · Aldo Torre Delgadillo, M.D. M.Sc (1) · Andrew L Mason, MBBS MRCPI (1) · Andrew Mason (1) · Atsushi Tanaka, MD, PhD (1) · Bruce Bacon, MD (1) · Catherine Vincent, MD FRCPC (1)
PMID 25543678, PMID 28249726, PMID 10051462, PMID 10343514, PMID 10347106, PMID 12360466, PMID 15017671, PMID 15128074, PMID 15468571, PMID 16299032, PMID 16530513, PMID 16848809, PMID 16863557, PMID 17399846, PMID 17680647, PMID 18041714, PMID 18752324, PMID 18778710, PMID 19491853, PMID 19554543, PMID 19782361, PMID 20578265, PMID 21083674, PMID 22245904, PMID 22259000, PMID 22271046, PMID 22454486, PMID 22911624, PMID 23141888, PMID 23490343, PMID 24317935, PMID 24440215, PMID 24625898, PMID 24671010, PMID 26966160, PMID 27121784, PMID 27148676, PMID 27532829, PMID 2803071, PMID 29181702, PMID 29790196, PMID 30240471, PMID 30922873, PMID 31606455, PMID 32717289, PMID 32758152, PMID 32950590, PMID 33319187, PMID 33769355, PMID 34487750
2014 (2), 2016 (2), 2019 (1)