10 completed, 8 recruiting, 4 terminated, 3 not yet recruiting. 12 Not applicable, 12 Phase 1, 3 Phase 2.
Follow Pediatric Brain Tumor: new trials by email Literature Review of Pediatric Brain Tumor trials Research Report on Pediatric Brain Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Multicenter Study to Assess the Feasibility of 5-Aminolevulinic Acid (5-ALA) in Pediatric Brain Tumor Patients Aminolevulinic acid hydrochloride - Pediatric Brain Tumor | Phase 2 | Not yet recruiting | Costas Hadjipanayis | 20 | 2027-08-01 | 2026-10-07 |
| Effectiveness of a Visual Telerehabilitation Program on Visual Perception in Children, Adolescents and Young Adults With Hemianopsia Consecutive to a Brain Tumour Visual Stimulation, standard of care - Hemianopsia, Virtual Reality | Not applicable | Not yet recruiting | Institut National de la Santé Et de la Recherche Médicale, France | 120 | 2026-12-01 | 2026-09-16 |
| GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults GPC2-CAR T cells, Fludarabine, Cyclophosphamide - Medulloblastoma, Central Nervous System Embryonal Tumor | Phase 1 | Recruiting | Stanford University | 18 | 2025-08-28 | 2026-10-09 |
| Survivors Journey+ Survivor's Journey+ - Pediatric Brain Tumor | Not applicable | Recruiting | Children's Hospital Medical Center, Cincinnati | 72 | 2025-08-01 | 2026-01-07 |
| Evaluation of the Neurologic Assessment in Pediatric Neuro-Oncology (pNANO) pNANO Assessment - Pediatric Brain Tumor, Pediatric Spine Tumor | Recruiting | University of Wisconsin, Madison | 252 | 2025-05-13 | 2026-07-21 | |
| The FLaME Cognitive Rehabilitation Study for Childhood Brain Tumour THE FATIGUE, LEARNING, AND MEMORY ENRICHMENT (FLaME) INTERVENTION - Full intervention, THE FATIGUE, LEARNING, AND MEMORY ENRICHMENT (FLaME) INTERVENTION - Cognitive rehabilitation only - Childhood Brain Tumor, Childhood Brain Tumors | Not applicable | Not yet recruiting | Great Ormond Street Hospital for Children NHS Foundation Trust | 36 | 2025-03-10 | 2025-01-13 |
| Non-Helium Magnetoencephalography in Pediatric Brain Tumors Magnetoencephalography plus Computed Tomography/Magnetic Resonance Imaging - Pediatric Brain Tumor | Recruiting | Guangzhou Women and Children's Medical Center | 100 | 2024-11-05 | 2025-04-24 | |
| Intra-Tumoral Injections of Natural Killer Cells for Recurrent Malignant Pediatric Brain Tumors Universal Donor (UD) Transforming growth factor beta imprinting (TGFβi) Natural Killer (NK) Cells, Implantation, Magnetic Resonance Imaging (MRI) - Pediatric Brain Tumor, Recurrent Pediatric Brain Tumor | Phase 1 | Suspended | Sabine Mueller, MD, PhD | 24 | 2024-05-31 | 2026-04-24 |
| High-Intensity Interval Exercise in Young Adult Survivors of Pediatric Brain Tumors: A Pilot Feasibility Study HIIT Exercise Program, Control Group - Pediatric Brain Tumor | Not applicable | Recruiting | Dana-Farber Cancer Institute | 30 | 2023-12-04 | 2026-02-24 |
| Feasibility/Acceptability of Attentional-Control Training in Survivors EndeavorRx, Control video game - Pediatric Cancer, Pediatric ALL | Not applicable | Recruiting | Children's National Research Institute | 50 | 2023-06-14 | 2025-01-10 |
| Targeting Pediatric Brain Tumors and Relapsed/Refractory Solid Tumors With Sodium Glucose Cotransporter 2 Inhibitors (SGLT2i) Dapagliflozin, Carmustine, Topotecan - Pediatric Brain Tumor, Pediatric Solid Tumor | Phase 1 | Recruiting | Washington University School of Medicine | 20 | 2023-04-03 | 2026-06-10 |
| Fitness to Aid the Brain and Cognitive Skills Web-based Aerobic Exercise Program - Pediatric Brain Tumor, Cognitive Impairment | Not applicable | Completed | The Hospital for Sick Children | 26 | 2021-10-07 | 2026-09-24 |
| Neoepitope-based Personalized Vaccine Approach in Pediatric Patients With Recurrent Brain Tumors Personalized peptide vaccine, Poly ICLC, Peripheral blood draw - Pediatric Brain Tumor | Phase 1 | Withdrawn | Washington University School of Medicine | 2021-09-30 | 2021-05-25 | |
| Study of Recombinant Human Endostatin Combined With CV Regimen in the Treatment of Pediatric Low-grade Gliomas combined therapy with rh-ES and CV - Low-grade Glioma, Pediatric Brain Tumor | Phase 2 | Completed | Beijing Sanbo Brain Hospital | 60 | 2020-11-03 | 2023-07-24 |
| Phase I Study of Marizomib + Panobinostat for Children With DIPG Marizomib, Panobinostat - Diffuse Intrinsic Pontine Glioma, Pediatric Brainstem Glioma | Phase 1 | Terminated | Dana-Farber Cancer Institute | 4 | 2020-08-10 | 2024-02-15 |
| 9-ING-41 in Pediatric Patients With Refractory Malignancies. 9-ING-41, Irinotecan, Temozolomide - Refractory Cancer, Refractory Neoplasm | Phase 1 | Terminated | Actuate Therapeutics Inc. | 40 | 2020-06-05 | 2025-07-17 |
| Integrated PET/MRI and Germline Variants to Differentiate Brain Tumopr Recurrence From Iatrogenicchanges in Children 11C-MET-PET/RMN - Pediatric Brain Tumor | Unknown | IRCCS San Raffaele | 60 | 2020-05-13 | 2024-01-26 | |
| HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors G207 - Neoplasms, Brain, Glioblastoma Multiforme | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 24 | 2019-09-12 | 2026-09-04 |
| Playful Sensorimotor Training in Pediatric Brain Tumor Patients Sensorimotor training - Pediatric Cancer, Pediatric Brain Tumor | Not applicable | Suspended | University of Basel | 20 | 2019-05-01 | 2019-04-19 |
| Therapeutic Targeting of Sex Differences in Pediatric Brain Tumor Glycolysis Ketogenic diet, BCNU - Pediatric Brain Tumor | Not applicable | Terminated | Washington University School of Medicine | 2 | 2019-05-01 | 2022-12-12 |
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Brain Neoplasms (10) · Neoplasms (10) · Glioblastoma (7) · Glioma (7) · Astrocytoma (6) · Medulloblastoma (6) · Neuroectodermal Tumors, Primitive (5) · Diffuse Intrinsic Pontine Glioma (4) · Ependymoma (4) · Rhabdoid Tumor (4) · Central Nervous System Neoplasms (3) · Neoplasms, Neuroepithelial (3) · Recurrence (3) · Choroid Plexus Carcinoma (2) · Gliosarcoma (2)
Neoplasms by Site (14) · Nervous System Diseases (14) · Brain Diseases (13) · Central Nervous System Diseases (13) · Nervous System Neoplasms (13) · Neoplasms (12) · Neoplasms by Histologic Type (12) · Central Nervous System Neoplasms (11) · Neoplasms, Nerve Tissue (11) · Neoplasms, Glandular and Epithelial (10) · Neuroectodermal Tumors (10) · Neoplasms, Germ Cell and Embryonal (9) · Neoplasms, Neuroepithelial (8) · Pathological Conditions, Signs and Symptoms (6) · Infratentorial Neoplasms (5)
Cyclophosphamide (3) · Carmustine (2) · Topotecan (2) · 3-(5-fluorobenzofuran-3-yl)-4-(5-methyl-5H-(1,3)dioxolo(4,5-f)indol-7-yl)-pyrrole-2,5-dione (1) · Aminolevulinic Acid (1) · CASP8 and FADD-Like Apoptosis Regulating Protein (1) · CLR1404 (1) · Cell Count (1) · Control Groups (1) · Diet, Ketogenic (1) · Diffusion Tensor Imaging (1) · Diphtheria Toxoid (1) · Drug Implants (1) · Educational Status (1) · Filgrastim (1)
Washington University School of Medicine (4) · Dana-Farber Cancer Institute (2) · Actuate Therapeutics Inc. (1) · Alaunos Therapeutics (1) · Beijing Sanbo Brain Hospital (1) · Cairo University (1) · Cellectar Biosciences, Inc. (1) · Children's Hospital Medical Center, Cincinnati (1) · Children's National Research Institute (1) · Costas Hadjipanayis (1) · Gary Archer Ph.D. (1) · Great Ormond Street Hospital for Children NHS Foundation Trust (1) · Guangzhou Women and Children's Medical Center (1) · Hospital Infantil de Mexico Federico Gomez (1) · IRCCS San Raffaele (1)
United States (20) · China (3) · Canada (2) · Italy (2) · United Kingdom (2) · Australia (1) · Austria (1) · Denmark (1) · France (1) · Mexico (1) · Netherlands (1) · South Korea (1) · Spain (1) · Switzerland (1) · Turkey (Türkiye) (1)
Andrew Cluster, M.D. (2) · Amy L Bredlau, MD (1) · Austin Stuckert, MD (1) · Charlotte P Malcolm, DClinPsy (1) · Christina Dieli-Conwright, PhD, MPH (1) · Constantinos G. Hadjipanayis, MD, PhD (1) · Daniel Landi, MD (1) · Donald J Mabbott (1) · Faraneh Vargha-Khadem, PhD (1) · Fiona Streckmann (1) · Giles W. Robinson, MD (1) · Gregory Friedman, MD (1) · Jarrod Longcor (1) · Jaymes Holland (1) · Jie MA, M.D., Ph.D. (1)
PMID 24327518, PMID 27424289, PMID 28053024, PMID 28672195, PMID 29383130, PMID 29846250, PMID 31101621, PMID 31533931, PMID 31831767, PMID 31882719, PMID 35266065, PMID 39582048
R21CA261877 (1)