43 completed, 11 recruiting, 9 active not recruiting, 8 unknown. 22 Not applicable, 15 Phase 2, 11 Phase 1, 11 Phase 3, 6 Phase 4.
Follow Osteogenesis Imperfecta: new trials by email Literature Review of Osteogenesis Imperfecta trials Research Report on Osteogenesis Imperfecta
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mesenchymal Cell Therapy in Osteogenesis Imperfecta (OI) Bone marrow-derived mesenchymal stromal cells (MSCs) - Osteogenesis Imperfecta, Osteogenesis Imperfecta Type III | Phase 1 / Phase 2 | Not yet recruiting | Emory University | 12 | 2027-01-01 | 2026-05-08 |
| Morphology in Oral Rare Syndromes & Artificial Intelligence for Clinical Diagnosis intra-oral 3D optical impression - Osteogenesis Imperfecta, Rare Bone Disorders | Not applicable | Not yet recruiting | University Hospital, Bordeaux | 240 | 2026-09-01 | 2026-06-24 |
| A Dose REgimen-Finding Study of AGA2115 in Chinese Patients With Osteogenesis ImpeRfecta (EIR) AGA2115 - Osteogenesis Imperfecta (OI) | Phase 2 | Recruiting | Angitia Biopharmaceuticals Guangzhou Limited | 48 | 2026-07-14 | 2026-09-22 |
| GRACE II (General Retrospective Analysis of Commercial Experience With AGN1 LOEP) AGN1 LOEP - Osteoporosis | Not yet recruiting | AgNovos Healthcare, LLC | 305 | 2026-06-01 | 2026-05-19 | |
| Pediatric Safety Follow-up Study of Prior Treatment With Romosozumab for Osteogenesis Imperfecta Vitamin D, Calcium - Osteogenesis Imperfecta | Phase 3 | Recruiting | Amgen | 71 | 2026-03-18 | 2026-06-22 |
| Osteogenesis Imperfecta Trial of AGA2115 for ADUlts With COL1A1 and/or COL1A2 GeNetic Variations (IDUN) AGA2115, Placebo - Osteogenesis Imperfecta (OI) | Phase 2 | Recruiting | Angitia Incorporated Limited | 80 | 2025-12-12 | 2026-10-14 |
| REMS25: Study on the Use of REMS Technology in Diseases Commonly Associated With Reduced Bone Mineral Density (BMD) REMS - Osteogenesis Imperfecta, Osteoporosis | Not applicable | Recruiting | Meyer Children's Hospital IRCCS | 100 | 2025-12-04 | 2026-02-17 |
| Social Cognition in Dystrophinopathies and Neurodevelopmental Disorders Electroencephalography (EEG), Social Cognition Tasks - Duchenne / Becker Muscular Dystrophy, Osteogenesis Imperfecta (OI) | Not yet recruiting | IRCCS Eugenio Medea | 45 | 2025-09-01 | 2025-03-13 | |
| Pediatric Arthropathy Beyond Inflammation: Clinical Spectrum and Diagnostic Approach at Assiut University Children Hospital Mucopolysaccharidoses, Progressive Pseudorheumatoid Dysplasia | Not yet recruiting | Assiut University | 35 | 2025-09-01 | 2025-09-15 | |
| An Interventional Study to Evaluate the Impact of Blood Flow Restriction Training on Muscle, Bone, and Quality of Life in Adults With Osteogenesis Imperfecta Type I Blood flow restriction training - Osteogenesis Imperfecta, Type I | Not applicable | Recruiting | University Hospital, Ghent | 40 | 2025-08-19 | 2026-03-17 |
| Prospective Observational Cohort Study of Cardiac Structure and Function in Children and Adults With Osteogenesis Imperfecta Imaging evaluation, Echocardiography - Osteogenesis Imperfecta (OI), Osteogenesis Imperfecta | Recruiting | Istituto Ortopedico Rizzoli | 40 | 2025-06-10 | 2025-12-17 | |
| Setrusumab in Pediatric Japanese Subjects With Osteogenesis Imperfecta setrusumab - Osteogenesis Imperfecta | Phase 3 | Active not recruiting | Ultragenyx Pharmaceutical Inc | 6 | 2024-10-25 | 2026-09-28 |
| Post-market Observational Study on JTIN Telescopic Nail in Osteogenesis Imperfecta Pediatric Patients JTIN implantation surgery - Osteogenesis Imperfecta | Completed | Orthofix s.r.l. | 14 | 2024-08-27 | 2026-01-26 | |
| Ready to Sail: Evaluating Sailing's Feasibility as Ergotherapy 5-day sailing activity - Multiple Osteochondroma, Ollier Disease | Not applicable | Completed | Istituto Ortopedico Rizzoli | 8 | 2024-05-16 | 2025-03-21 |
| Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta Romosozumab, Bisphosphonate - Osteogenesis Imperfecta | Phase 3 | Active not recruiting | Amgen | 111 | 2024-04-22 | 2026-05-27 |
| Adapted Physical Activity Program (APA) for Effort Rehabilitation of Children and Teenagers With Osteogenesis Imperfecta Adapted Physical Activity program - Osteogenesis Imperfecta | Not applicable | Recruiting | University Hospital, Toulouse | 30 | 2024-02-26 | 2026-05-08 |
| Site Preservation After Tooth Extraction Osteogenesis Imperfecta, Total Absence of Permanent Teeth | Not yet recruiting | Nanfang Hospital, Southern Medical University | 88 | 2023-11-01 | 2023-03-30 | |
| A First-in-Human Study Evaluating AGA2115 in Adult Healthy Volunteers AGA2115, Placebo - Osteogenesis Imperfecta | Phase 1 | Completed | Angitia Incorporated Limited | 72 | 2023-10-03 | 2025-01-10 |
| Study of Osteogenesis Imperfecta Tendon study tendon damage in osteogenesis imperfecta patients - Osteogenesis Imperfecta | Unknown | Université Catholique de Louvain | 130 | 2023-09-13 | 2023-10-03 | |
| Management of Combined Fracture Neck of Femur and Femoral Deformity in Osteogenesis Imperfecta Patient corrective osteotomy and intramedullary telescoping nail for deformed femur and Wagner technique to fix NOF fracture - Osteogenesis Imperfecta | Not applicable | Unknown | Assiut University | 1 | 2023-08-01 | 2024-01-31 |
Showing 20 of 84. Sign in to see all of them.
Fractures, Bone (5) · Osteoporosis (5) · Bone Diseases, Metabolic (4) · Congenital Abnormalities (3) · Exostoses, Multiple Hereditary (3) · Osteogenesis imperfecta, type 3 (3) · Rare Diseases (3) · Brittle Bone Disorder (2) · Connective Tissue Diseases (2) · Enchondromatosis (2) · Motor Activity (2) · Mucopolysaccharidoses (2) · Mucopolysaccharidosis IV (2) · Arthropathy, progressive pseudorheumatoid, of childhood (1)
Bone Diseases, Developmental (84) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (84) · Osteochondrodysplasias (84) · Skin and Connective Tissue Diseases (84) · Bone Diseases (83) · Collagen Diseases (83) · Genetic Diseases, Inborn (83) · Musculoskeletal Diseases (83) · Connective Tissue Diseases (82) · Metabolic Diseases (11) · Nutritional and Metabolic Diseases (11) · Wounds and Injuries (7) · Metabolism, Inborn Errors (5) · Nervous System Diseases (5) · Pathological Conditions, Signs and Symptoms (5)
setrusumab (7) · Zoledronic Acid (6) · Diphosphonates (4) · Vitamin D (4) · Calcium (3) · Denosumab (3) · Pamidronate (3) · Risedronic Acid (3) · Teriparatide (3) · Alendronate (2) · Bone Marrow Transplantation (2) · romosozumab (2) · Blood Flow Restriction Therapy (1) · Blood Specimen Collection (1) · Busulfan (1)
Ultragenyx Pharmaceutical Inc (7) · Baylor College of Medicine (6) · Amgen (5) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (5) · Istituto Ortopedico Rizzoli (5) · Assiut University (4) · St. Jude Children's Research Hospital (3) · Angitia Incorporated Limited (2) · Hospices Civils de Lyon (2) · IRCCS Eugenio Medea (2) · Novartis Pharmaceuticals (2) · Sheffield Children's NHS Foundation Trust (2) · University of South Florida (2) · AgNovos Healthcare, LLC (1) · Al-Azhar University (1)
United States (38) · France (16) · Canada (15) · Italy (14) · United Kingdom (10) · Germany (9) · Belgium (8) · Australia (7) · Poland (6) · Spain (6) · Egypt (5) · Hungary (5) · Brazil (3) · Czechia (3) · Denmark (3)
Frank Rauch, M.D. (3) · Joshua J Zimmerberg, M.D. (3) · Jeffrey Krischer, Ph.D. (2) · Joan C Marini, M.D. (2) · Kimberly Kasow, DO (2) · Alicia McCarthy, MSN (1) · Alix Seif, MD (1) · Bente Langdahl, MD (1) · Brendan Lee, M.D., Ph.D. (1) · Brendan Lee, M.D., PhD (1) · Cathleen Raggio, MD (1)
PMID 42470570, PMID 10831929, PMID 11415789, PMID 18804556, PMID 22210669, PMID 22829629, PMID 23666771, PMID 23927913, PMID 24463451, PMID 26388606, PMID 26610319, PMID 26924265, PMID 26987995, PMID 27448250, PMID 2805382, PMID 28472303, PMID 28595941, PMID 29066999, PMID 30805524, PMID 34430024, PMID 34519823, PMID 35113812, PMID 35223854, PMID 3591830, PMID 37197785, PMID 37715362, PMID 37927741, PMID 38261781, PMID 38834319, PMID 39012717, PMID 39246942, PMID 39871223, PMID 40221747, PMID 41131085, PMID 9561014
2023 (3), 2016 (2), U01TR001263 (2), 2014 (1), 2015 (1), 2017 (1), 2018 (1), UL1RR024140 (1)