29 completed, 21 recruiting, 10 active not recruiting, 9 unknown. 26 Phase 2, 21 Not applicable, 11 Phase 3, 7 Phase 1.
Follow Oropharynx Cancer: new trials by email Literature Review of Oropharynx Cancer trials Research Report on Oropharynx Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dose Adjusted Chemoradiotherapy in HPV-Associated Oropharynx Cancer of the Elderly Modified dose and fields intensity modulated radiotherapy - Oropharynx Cancer, Frailty | Not applicable | Recruiting | Omar Mahmoud | 20 | 2025-12-15 | 2026-09-29 |
| E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers E7 TCR-T cells, Aldesleukin - HPV-Associated Cervical Carcinoma, HPV-Related Carcinoma | Phase 1 / Phase 2 | Recruiting | Christian Hinrichs | 15 | 2025-08-11 | 2026-10-06 |
| Sparing Parotid Ducts Via MRI Sialography for Reduced Patient Reported Xerostomia standard radiotherapy, experimental radiotherapy - Oropharynx Cancer, Head and Neck Cancer | Not applicable | Withdrawn | UNC Lineberger Comprehensive Cancer Center | 2025-08-08 | 2025-09-05 | |
| Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States Population Celecoxib, Erlotinib Hydrochloride, Imaging Procedure - Metastatic Oral Cavity Carcinoma, Recurrent Oral Cavity Carcinoma | Phase 2 | Recruiting | Mayo Clinic | 25 | 2025-08-07 | 2026-10-01 |
| A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC) Sacituzumab Govitecan, Cetuximab - Squamous Cell Carcinoma of Head and Neck, Sinus Cancer | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 40 | 2025-07-02 | 2026-02-19 |
| Prevalence of Human Papillomavirus (HPV) in a Healthy Population: A Feasibility Study of Oropharyngeal Cancer Screening Self-sampling by gargling kit at dental clinic, Questionnaire, Self-sampling by gargling kit at home - Oropharynx Cancer | Not applicable | Recruiting | The Institute of Molecular and Translational Medicine, Czech Republic | 20000 | 2025-06-01 | 2026-02-13 |
| Lymphocyte-Sparing And Radio-Immunotherapy in Head and Neck Carcinoma Vesanoid, Standard radiotherapy, Tailored radiotherapy - Oropharynx Cancer, Larynx Cancer | Phase 3 | Recruiting | Centre Leon Berard | 460 | 2025-02-20 | 2026-04-24 |
| Personalized Volume-deescalated Elective Nodal Irradiation in Oropharyngeal Head and Neck Squamous Cell Carcinoma De-escalation of irradiated volume - Oropharynx Cancer | Phase 2 | Recruiting | University of Zurich | 120 | 2025-02-04 | 2026-10-08 |
| Feasibility of Adaptive Radiation Therapy for Human-papilloma Virus-positive Oropharyngeal Cancer Patients on MRIdian Linac MRIdian Linac - Oropharynx Cancer | Not applicable | Withdrawn | University of Miami | 2024-12-01 | 2024-09-19 | |
| Oncology, Undernutrition and Sensoriality: Links, Mechanisms and Levers for Action tests/questionnaires, biological samples, evaluation - Oropharynx Cancer, Oral Cavity | Recruiting | Centre Hospitalier Universitaire Dijon | 306 | 2024-09-06 | 2026-10-08 | |
| Can Recurrence of Cancer in the Oropharynx be Detected by Blood Samples? Liquid biopsy - Oropharynx Cancer, Oropharynx Cancer, Metastatic | Active not recruiting | Copenhagen University Hospital, Rigshospitalet | 200 | 2024-04-02 | 2025-11-18 | |
| Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL) Experimental Observation, Observation per Standard of Care, Adjuvant Treatment per Standard of Care - Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma | Phase 2 | Recruiting | University of Maryland, Baltimore | 61 | 2024-03-07 | 2025-11-10 |
| Neoadjuvant Immunoradiotherapy With Evorpacept and Pembrolizumab in HPVOPC (Human Papilloma Virus Oropharynx Cancer) Evorpacept - Oropharynx Cancer | Phase 2 | Active not recruiting | University of California, San Diego | 28 | 2024-02-23 | 2026-07-16 |
| A Study of Concurrent Chemoradiation in Combination With or Without PD1 Inhibitor AB122 Adenosine 2a Receptor / Adenosine 2b Receptor Inhibitor AB928 Therapies in Locally Advanced Head and Neck Cancers Zimberelimab, Etrumadenant, Cisplatin - Head and Neck Cancer, Squamous Cell Carcinoma of Head and Neck | Phase 1 | Withdrawn | Jennifer Choe | 2023-12-31 | 2023-11-30 | |
| Trial of Individualized Adaptive RT in HPV-related High Risk Oropharynx Cancer Radiation, Platinum based chemotherapy - Oropharynx Cancer, HPV-Related Carcinoma | Phase 2 | Active not recruiting | University of Michigan Rogel Cancer Center | 19 | 2023-12-20 | 2026-05-18 |
| Evaluation of the Benefit of a New Surgical Procedure According to IDEAL Recommendations for ORL Cancer Patients: the External Pudendal Flap Used as a New Free Flap for Oral Cavity/Oropharyngeal Reconstruction to Limit Donor Site Sequelae Oropharyngeal or oral cavity reconstruction - Head and Neck Cancer, Oral Cavity Cancer | Not applicable | Recruiting | Institut Claudius Regaud | 40 | 2023-11-08 | 2025-09-15 |
| Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy ENDURE - Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma | Not applicable | Recruiting | Medical University of South Carolina | 532 | 2023-10-30 | 2025-12-11 |
| Arabic PRO Measures for Head and Neck Cancer Radiotherapy. Radiation - Head and Neck Cancer, Head and Neck Neoplasms | Recruiting | King Saud University | 125 | 2023-05-01 | 2024-10-29 | |
| Real-time Targeted Fluorescence Endoscopy for Detection of the Primary Cancer Lesion in Patients With a Metastasis of Unknown Primary Tumor in the Head and Neck Detection of lesions using fluorescence molecular imaging - Unknown Primary Tumors, Oropharynx Cancer | Not applicable | Unknown | University Medical Center Groningen | 35 | 2023-04-28 | 2023-10-25 |
| The ENHANCE Study: Exercise and Nutrition in Head And Neck CancEr Survivors ENHANCE Intervention - Exercise and Nutrition, ENHANCE Intervention - Nutrition Only - Oral Cavity Cancer, Oropharynx Cancer | Not applicable | Completed | H. Lee Moffitt Cancer Center and Research Institute | 40 | 2023-04-06 | 2026-09-17 |
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Oropharyngeal Neoplasms (78) · Head and Neck Neoplasms (26) · Mouth Neoplasms (22) · Squamous Cell Carcinoma of Head and Neck (20) · Laryngeal Neoplasms (17) · Hypopharyngeal Neoplasms (16) · Carcinoma, Squamous Cell (7) · Tonsillar Neoplasms (6) · Deglutition Disorders (4) · Nasopharyngeal Neoplasms (4) · Neoplasm Metastasis (4) · Papillomavirus Infections (4) · Uterine Cervical Neoplasms (4) · Xerostomia (4) · Anus Neoplasms (3)
Neoplasms by Site (77) · Stomatognathic Diseases (77) · Neoplasms (76) · Otorhinolaryngologic Diseases (76) · Otorhinolaryngologic Neoplasms (76) · Pharyngeal Diseases (76) · Pharyngeal Neoplasms (76) · Head and Neck Neoplasms (52) · Mouth Diseases (27) · Neoplasms by Histologic Type (26) · Carcinoma (25) · Neoplasms, Glandular and Epithelial (25) · Carcinoma, Squamous Cell (18) · Respiratory Tract Diseases (17) · Respiratory Tract Neoplasms (17)
Cisplatin (15) · Radiotherapy, Intensity-Modulated (6) · Carboplatin (5) · Radiation (5) · Radiotherapy (5) · pembrolizumab (5) · Cetuximab (4) · Blood Specimen Collection (3) · Docetaxel (3) · Fluorouracil (3) · durvalumab (3) · Adoptive Transfer (2) · Chemoradiotherapy (2) · Drug Therapy (2) · Immunotherapy (2)
Copenhagen University Hospital, Rigshospitalet (5) · M.D. Anderson Cancer Center (3) · Memorial Sloan Kettering Cancer Center (3) · UNC Lineberger Comprehensive Cancer Center (3) · Center Eugene Marquis (2) · Centre Leon Berard (2) · Centre hospitalier de l'Université de Montréal (CHUM) (2) · Christian Hinrichs (2) · Christian von Buchwald (2) · Groupe Oncologie Radiotherapie Tete et Cou (2) · Gustave Roussy, Cancer Campus, Grand Paris (2) · Loren Mell, MD (2) · Mayo Clinic (2) · University Health Network, Toronto (2) · University Medical Center Groningen (2)
United States (42) · France (13) · Denmark (8) · Canada (7) · Germany (3) · Czechia (2) · Netherlands (2) · Switzerland (2) · Australia (1) · Cyprus (1) · Saudi Arabia (1) · South Korea (1) · Sweden (1)
Christian S Hinrichs, MD (2) · Jean Bourhis, PhD (2) · Tobias Todsen, MD, PhD (2) · Acharf Shamseddine, MD (1) · Assuntina Sacco, M.D. (1) · C. Jillian Tsai, MD (1) · Carole Fakhry, MD, MPH (1) · Catriona Steele, PhD (1) · Charlotte Lynggaard, MD (1) · Chris Holsinger (1) · Christian Von Buchwald, MD, DMSc (1) · Christian von Buchwald, MD, DMSc. (1) · Christian von Buchwald, MD, dr. med. (1) · Christian von Buchwald, Professor, MD, DMSci (1)
PMID 42032732, PMID 21831465, PMID 23083061, PMID 26186556, PMID 28498880, PMID 30406032, PMID 32417348, PMID 32479189, PMID 33963014, PMID 33989559, PMID 34108183, PMID 34808255, PMID 35446279, PMID 36239625, PMID 37261806, PMID 38573597, PMID 39325260, PMID 39636629, PMID 40260766, PMID 40402484, PMID 40692081, PMID 40907518, PMID 41570275, PMID 42200110
2018 (2), 2009 (1), P50DE026787 (1), R01CA282165 (1), R01DC011020 (1), U01CA183848 (1), U01CA287904 (1)