78 completed, 41 unknown, 31 recruiting, 15 not yet recruiting. 68 Not applicable, 22 Phase 2, 13 Phase 3, 11 Phase 1, 3 Phase 4.
Follow Oral Cancer: new trials by email Literature Review of Oral Cancer trials Research Report on Oral Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Risk Factors of Jaw Osteoradionecrosis in Oral Cavity Cancer Patients Post-Radiotherapy Osteoradionecrosis, Radiotherapy | Not yet recruiting | AO Innovation Translation Center | 1000 | 2027-03-01 | 2026-09-23 | |
| Feasibility and Validation of an Automated AI-Enabled Deep Ultraviolet (DUV) Cytology Platform for Point-of-Care Oral Cancer Triage Deep UV-M and AI Cytology Triage - Oral Potentially Malignant Lesions, Oral Potentially Malignant Disorders | Not applicable | Not yet recruiting | Anh Le | 270 | 2026-12-01 | 2026-09-25 |
| Oral Cancer Awareness in Egypt Questionnaire - Oral Cancer | Not yet recruiting | Ayat Gamal-AbdelNaser | 1844 | 2026-12-01 | 2026-09-29 | |
| Window Trial of Intratumoral (IT) Neoadjuvant Fluorescently Labelled Nivolumab (nivo800) in Head and Neck Squamous Cell Carcinoma (HNSCC) Nivolumab-IRDye800 - HNSCC, SCC - Squamous Cell Carcinoma | Early Phase 1 | Recruiting | Vanderbilt-Ingram Cancer Center | 18 | 2026-09-30 | 2026-10-19 |
| Rehabilitation Through Individualized Support and Exercise Tailored physiotherapy program for early mobilization after oral cancer surgery - Oral Cancer, Head and Neck Cancer | Not applicable | Not yet recruiting | Universitaire Ziekenhuizen KU Leuven | 39 | 2026-09-10 | 2026-10-05 |
| Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions 5-Amino Levulinic Acid - Oral Cancer, Oral Cavity Cancer | Phase 2 | Not yet recruiting | University of Massachusetts, Boston | 65 | 2026-09-01 | 2026-03-19 |
| A Feasibility Study of AI-Assisted Physiotherapy for Oral Cancer Patients AI-assisted physiotherapy - AI (Artificial Intelligence), Oral Cancer | Not applicable | Not yet recruiting | National Taiwan University Hospital | 15 | 2026-07-27 | 2026-07-20 |
| Disease Evolution and Risk Factors of AIDS-related Prevalent Cancers HIV (Human Immunodeficiency Virus), AIDS | Not yet recruiting | Shenzhen Third People's Hospital | 1000 | 2026-07-01 | 2026-07-10 | |
| AI-based Physiotherapy Evaluation System for Range of Motion in Oral Cancer Patients Oral Cancer, AI (Artificial Intelligence) | Recruiting | National Taiwan University Hospital | 20 | 2026-04-07 | 2026-04-13 | |
| Resection and Defect Repair of Oral Cancer Aided by Mixed Reality Technology Unreal Engine 5 (UE5)-based Mixed Reality (MR) Technology-assisted Resection of Oral Cancer and Defect Reconstruction, Virtual Surgical Guide Technology-assisted Resection of Oral Cancer and Defect Reconstruction - Tongue Squamous Cell Carcinoma, Mixed Reality | Not applicable | Not yet recruiting | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | 30 | 2026-04-01 | 2026-03-20 |
| Surgery With or Without Neoadjuvant Treatment of SBRT Plus Chemoimmunotherapy in Resectable Locally Advanced Oral and HPV-unrelated Oropharyngeal Squamous Cell Carcinoma Neoadjuvant treatment of SBRT plus chemoimmunotherapy followed by surgery and postoperative radiotherapy or chemoradiotherapy, Surgery and postoperative radiotherapy or chemoradiotherapy - Oral Cancer, Oropharyngeal Cancer | Phase 3 | Not yet recruiting | Sun Yat-sen University | 184 | 2026-02-24 | 2026-02-11 |
| Effectiveness of Opioid vs Pregabalin Plus Naproxen Sodium in Pain Management of Oral Cancer Patients Tramadol, Pregabalin + Naproxen Sodium - Oral Cancer, Oral Cavity Cancer | Not applicable | Enrolling by invitation | Mayo Hospital Lahore | 98 | 2026-02-01 | 2026-05-26 |
| Effectiveness of Hydrogen Water Intervention on Acute Oral Inflammation, Oral Microbiota, and Pain Following Free Flap Reconstruction in Patients With Oral Cancer Hydrogen Water Oral Care, Water Oral Care - Oral Squamous Cell Carcinoma (OSCC), Postoperative Pain | Not applicable | Not yet recruiting | Kaohsiung Medical University Chung-Ho Memorial Hospital | 36 | 2026-01-01 | 2025-12-29 |
| App-Assisted Swallowing Program After Oral Cancer Surgery Swallowing Care + Exercise App, Routine Postoperative Care - Oral Cancer, Reconstructive Surgery | Not applicable | Not yet recruiting | Chang Gung Memorial Hospital | 72 | 2026-01-01 | 2025-12-24 |
| Evaluation of Two Non-Invasive Methods, High-Resolution Microendoscopy and Liquid-Based Cytology, for Detection of Oral Precancer High-resolution microendoscopy of visible oral precancerous lesions, Standard of care - Oral Precancer, Oral Cancer | Not applicable | Recruiting | Anil Chaturvedi | 400 | 2025-12-15 | 2026-04-14 |
| Real-time Molecular Diagnosis of Oral Precancer LIP device - Oral Cancer, Dysplasia | Completed | King's College London | 40 | 2025-12-11 | 2026-08-27 | |
| Tongue Proactive Strengthening Exercise Program Following Partial/Hemi Glossectomy and Reconstruction Tongueometer - Oral Cancer, Head and Neck Cancer | Not applicable | Recruiting | Case Comprehensive Cancer Center | 40 | 2025-12-10 | 2026-08-06 |
| AI Based Physiotherapy 3- and 9-Month Follow-Up in Oral Cancer Patients AI-based physiotherapy follow-up assessments, conventional physiotherapy follow-up assessments - Oral Cancer | Not applicable | Recruiting | National Taiwan University Hospital | 65 | 2025-12-06 | 2025-12-16 |
| Exploratory Study of Inhaled Afatinib Dimaleate PK Profile Afatinib Dimaleat, inhalation of afatinib dimaleate - Lung Cancer, Oral Cancer | Phase 1 | Terminated | Petrov, Andrey | 4 | 2025-11-09 | 2026-06-03 |
| Morphological Changes of Upper Trapezius Muscle After Physotherapy in Oral Cancer B-mode ultrasonography - Oral Cancer | Recruiting | National Taiwan University Hospital | 10 | 2025-10-16 | 2026-07-21 |
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Mouth Neoplasms (177) · Squamous Cell Carcinoma of Head and Neck (28) · Head and Neck Neoplasms (26) · Oropharyngeal Neoplasms (20) · Leukoplakia, Oral (9) · Carcinoma, Squamous Cell (8) · Laryngeal Neoplasms (8) · Lichen Planus, Oral (8) · Hypopharyngeal Neoplasms (6) · Neoplasms (6) · Breast Neoplasms (5) · Lung Neoplasms (5) · Esophageal Neoplasms (4) · Pharyngeal Neoplasms (4) · Tongue Neoplasms (4)
Stomatognathic Diseases (177) · Neoplasms by Site (176) · Mouth Diseases (174) · Neoplasms (171) · Head and Neck Neoplasms (151) · Neoplasms by Histologic Type (37) · Carcinoma (34) · Neoplasms, Glandular and Epithelial (34) · Pathological Conditions, Signs and Symptoms (33) · Otorhinolaryngologic Diseases (29) · Pharyngeal Diseases (27) · Otorhinolaryngologic Neoplasms (26) · Carcinoma, Squamous Cell (25) · Pharyngeal Neoplasms (21) · Pathologic Processes (18)
Drug Therapy (6) · Radiotherapy (6) · Cisplatin (5) · Chemoradiotherapy (3) · Fluorouracil (3) · Positron Emission Tomography Computed Tomography (3) · Radiation (3) · Aminolevulinic Acid (2) · Biopsy (2) · Carboplatin (2) · Cetuximab (2) · Chlorhexidine (2) · Metformin (2) · Standard of Care (2) · Surgical Procedures, Operative (2)
National Taiwan University Hospital (21) · Cairo University (11) · Chang Gung Memorial Hospital (5) · M.D. Anderson Cancer Center (5) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (5) · Banaras Hindu University (4) · Shanghai Jiao Tong University School of Medicine (4) · Tata Memorial Hospital (4) · Copenhagen University Hospital, Rigshospitalet (3) · International Agency for Research on Cancer (3) · NYU Langone Health (3) · University of British Columbia (3) · British Columbia Cancer Agency (2) · Case Comprehensive Cancer Center (2) · China Medical University Hospital (2)
United States (36) · Taiwan (34) · China (18) · Egypt (16) · India (14) · Netherlands (7) · Canada (6) · France (6) · Denmark (5) · United Kingdom (4) · Italy (3) · Sweden (3) · Belgium (2) · Brazil (2) · Pakistan (2)
Yueh-Hsia Chen, PhD (5) · Shin-Jung Cheng, DDS, MS, PhD (3) · Yueh-Hsia Chen, Master (3) · Ann M. Gillenwater, MD (2) · Carter Van Waes, M.D. (2) · Chen-ping Zhang, MD, PhD (2) · Ching-Ting Tan, MD, PhD (2) · Chun-Pin Chiang, DMSc (2) · Jean Bourhis, PhD (2) · Lai-ping Zhong, MD, PhD (2) · Manoj Pandey (2) · Tayyaba Hasan, PhD (2) · Yueh-Hsia Chen, Ph.D. (2) · Afeez Salami, BDS (1) · Ahmed Hassoon, MD,MPH,PMP (1)
PMID 12361079, PMID 12988177, PMID 15172646, PMID 15979480, PMID 18457329, PMID 20014446, PMID 20623305, PMID 21541945, PMID 22108231, PMID 22422558, PMID 22864015, PMID 23720248, PMID 24817237, PMID 10071296, PMID 10772298, PMID 11754498, PMID 12625522, PMID 15459926, PMID 19260131, PMID 20299249, PMID 21537629, PMID 21794962, PMID 22947240, PMID 23358022, PMID 23431215, PMID 24478217, PMID 24658376, PMID 24909649, PMID 25224592, PMID 25613348, PMID 25931658, PMID 10459885, PMID 10646723, PMID 11246687, PMID 11246689, PMID 11308246, PMID 11841126, PMID 11914437, PMID 12576033, PMID 1472184, PMID 15162149, PMID 15162353, PMID 15936419, PMID 16025260, PMID 1609875, PMID 16253509, PMID 16284994, PMID 16300724, PMID 16331595, PMID 16719675
2008 (1), 2019 (1), 5UH3CA189901-04 (1), K23DE016890 (1), K23DE034496 (1), P01CA106451 (1), P50CA261605 (1), R01CA173465 (1), R01DE028555 (1), R03CA273391 (1), R21DE032844 (1), U01CA279862 (1)