2 completed, 1 terminated, 1 withdrawn. 4 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 4 | Completed 2, Terminated 1, Withdrawn 1 |
| Phase 2 | 2 | Completed 1, Terminated 1 |
Follow Opioid Withdrawal: new trials by email Literature Review of Opioid Withdrawal trials Research Report on Opioid Withdrawal
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Treatment of Restless Legs Symptoms With Pramipexole to Improve the Outcomes of Protracted Opioid Withdrawal in OUD Pramipexole, Placebo - Sleep Disorder, Restless Legs Syndrome | Phase 2 / Phase 3 | Terminated | Massachusetts General Hospital | 75 | 2022-01-24 | 2025-09-22 |
| An Innovative Intervention for OUD Treatment Bridge Device, Lofexidine, Placebo - Opioid-Related Disorders, Opioid Dependence | Phase 2 / Phase 3 | Completed | Johns Hopkins University | 36 | 2020-11-15 | 2026-06-09 |
| Comparison of Three Opioid Detoxification Treatment Regimens Buprenorphine/naloxone, Morphine, Tramadol - Opioid-Related Disorders, Opioid Withdrawal | Phase 3 | Withdrawn | University of Alabama at Birmingham | 2019-11-15 | 2019-11-05 | |
| Open-Label, Safety Study of Lofexidine Lofexidine - Opioid Withdrawal | Phase 3 | Completed | USWM, LLC (dba US WorldMeds) | 286 | 2015-02-01 | 2022-03-22 |
Opioid-Related Disorders (3) · Restless Legs Syndrome (1) · Sleep Wake Disorders (1)
Chemically-Induced Disorders (3) · Mental Disorders (3) · Narcotic-Related Disorders (3) · Substance-Related Disorders (3) · Dyssomnias (1) · Nervous System Diseases (1) · Neurologic Manifestations (1) · Parasomnias (1) · Pathological Conditions, Signs and Symptoms (1) · Signs and Symptoms (1) · Sleep Disorders, Intrinsic (1)
lofexidine (2) · Buprenorphine, Naloxone Drug Combination (1) · Morphine (1) · Pramipexole (1) · Tramadol (1)
Johns Hopkins University (1) · Massachusetts General Hospital (1) · USWM, LLC (dba US WorldMeds) (1) · University of Alabama at Birmingham (1)
United States (4)
Charles W Gorodetzky, MD, PhD (1) · Eric Strain (1) · John W Winkelman, MD/PhD (1)
R01DA048761 (1), R21DA052861 (1), U01DA033276 (1)