22 recruiting, 8 unknown, 6 active not recruiting, 5 not yet recruiting. 19 Phase 2, 17 Not applicable, 5 Phase 3, 2 Phase 1, 1 Early Phase 1.
Follow Oligometastatic Disease: new trials by email Literature Review of Oligometastatic Disease trials Research Report on Oligometastatic Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Local Ablation Plus Systemic Therapy for Metachronous Liver and/or Lung Oligometastases From Nasopharyngeal Carcinoma CT-guided percutaneous local ablation, Gemcitabine, Cisplatin - Nasopharyngeal Carcinoma, Neoplasm Metastasis | Phase 2 | Not yet recruiting | Sun Yat-sen University | 138 | 2026-10-01 | 2026-09-17 |
| MRI-Guided Adaptive Radiotherapy for Limited Peritoneal Metastases (MARACAS Trial). MRI-guided stereotactic body radiotherapy - Peritoneal Carcinomatosis, Oligometastatic Disease | Phase 2 | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 34 | 2026-07-01 | 2026-05-18 |
| Trial of Oligometastasis SBRT With Immediate, Simulation-Free Treatment Delivery (OLIGO-SWIFT) Simulation-free workflow, SBRT - Oligometastasis, Oligometastatic Disease | Phase 1 | Recruiting | Case Comprehensive Cancer Center | 15 | 2026-02-27 | 2026-09-29 |
| 125I Seed Implantation Plus Systemic Therapy for Oligoprogressive NSCLC or Colorectal Cancer Standard-of-Care Systemic Therapy, 125I Seed Implantation - Oligometastatic Disease | Phase 2 | Not yet recruiting | Li Min | 90 | 2026-01-01 | 2026-01-12 |
| Stereotactic Radiotherapy Versus Palliative Conventional Radiotherapy for Oligoprogressive Metastatic Cancers Stereotactic ablative radiotherapy (SABR), Palliative radiotherapy - Oligoprogression, Oligometastatic Disease | Not applicable | Recruiting | British Columbia Cancer Agency | 194 | 2025-12-04 | 2025-12-15 |
| Systemic Therapy in Combination with Stereotactic Radiotherapy in Patients with Metastatic Colorectal Cancer Up to 10 Metastatic Sites Stereotactic body radiation therapy (SBRT), Maintenance therapy (CAP-B or 5-FU/LV plus bevacizumab.) - Metastatic Colorectal Cancer, Oligometastatic Disease | Phase 2 | Suspended | UMC Utrecht | 93 | 2025-12-01 | 2025-03-28 |
| Real-Time Atherosclerosis Activity After Thoracic Radiotherapy Using Sodium Fluoride Positron Emission Tomography 18-F-NaF Cardiac PET/MRI and, CT Angiogram - Oligometastatic Disease | Early Phase 1 | Recruiting | Katelyn Atkins | 10 | 2025-06-19 | 2026-08-06 |
| Chemoimmunotherapy Followed by Surgery for Oligometastatic Esophagogastric Cancer: (TORO Protocol) Surgical resection followed by preoperative chemoimmunotherapy for oligometastatic esophagogastric cancer - Esophageal Cancer, Gastric Cancer | Not applicable | Recruiting | University Health Network, Toronto | 72 | 2025-05-09 | 2025-05-16 |
| Single vs. Multiple Fraction Trial of Stereotactic Ablative Radiotherapy for Comprehensive Treatment of Oligometastases/Progression Single fraction SABR, Multiple fraction SABR, QoL reporting alone - Oligometastatic Disease, Oligoprogression | Not applicable | Recruiting | Robert Olson | 598 | 2025-04-16 | 2026-09-24 |
| OligoCare TwiCs (Trials Within Cohorts) Trial Comparing Acute Toxicity in Single-fraction vs Multiple-fraction SBRT for Metastasis-directed Treatment (SPRINT) single-fraction SBRT, multiple-fraction SBRT - Breast Cancer, Prostate Cancer | Not applicable | Recruiting | European Organisation for Research and Treatment of Cancer - EORTC | 302 | 2025-04-15 | 2025-08-01 |
| Feasibility Trial of Darwin OncoTreat and OncoTarget Precision Medicine Testing Darwin OncoTarget and OncoTreat - Personalized Medicine, Oligometastatic Disease | Not applicable | Not yet recruiting | Good Samaritan Hospital Medical Center, New York | 20 | 2025-03-10 | 2025-02-24 |
| Niraparib Rechallenge After Surgery in Ovarian Cancer Patients With Oligometastatic Progression Niraparib oral tablets - Ovarian Cancer, Oligometastatic Disease | Phase 2 | Recruiting | MedSIR | 30 | 2024-12-03 | 2026-04-22 |
| Lymphocyte Support to SBRT in Patients With Oligo-metastatic Solid Cancer all-trans retinoic acid, Stereotactic Body Radiation Therapy - Oligometastatic Disease, Solid Tumor, Adult | Phase 1 / Phase 2 | Recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 58 | 2024-07-11 | 2025-12-01 |
| Stereotactic Radiotherapy for Oligometastasis (1-5) in Various Tumor Sites vs. Palliative Care stereotactic ablative radiation therapy, palliative radiation therapy, Chemotherapy - Oligometastatic Disease | Phase 2 / Phase 3 | Recruiting | National Medical Research Radiological Centre of the Ministry of Health of Russia | 100 | 2024-05-31 | 2024-08-16 |
| Outcomes of Local Treatment for Oligometastatic Prostate Cancer Diagnosed Using PSMA PET Imaging: OLIGOMET Study Radical prostatectomy, Prostate irradiation, Surgical metastasectomy - Prostate Cancer Metastatic, Prostate Cancer Metastatic to Bone | Not yet recruiting | Medical University of Vienna | 500 | 2024-05-31 | 2024-05-28 | |
| Surgical Resection of Synchronous Pulmonary or Hepatic Oligometastatic Pancreatic Ductal Adenocarcinoma Surgery - Pancreatic Ductal Adenocarcinoma, Oligometastatic Disease | Not applicable | Terminated | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 5 | 2024-05-21 | 2026-04-15 |
| High-Risk Metachronous Oligometastatic Prostate Cancer Trial niraparib/abiraterone acetate, Stereotactic ablative radiation therapy (SABR), Androgen deprivation therapy (ADT) - Prostate Cancer, Oligometastatic Disease | Phase 2 | Active not recruiting | University of Maryland, Baltimore | 88 | 2024-04-17 | 2026-05-06 |
| Longitudinal Study of Local Ablative Therapy in Oligometastatic Disease Local ablative therapy (LAT) - Oligometastatic Disease, Metastases | Not applicable | Recruiting | Gitte Fredberg Persson MD PhD | 1200 | 2024-04-15 | 2024-04-16 |
| Study of PULSAR-ICI +/- IMSA101 in Patients With Oligometastatic NSCLC and RCC IMSA101, Immune checkpoint inhibitor, PULSAR - Oligometastatic Disease | Phase 2 | Terminated | ImmuneSensor Therapeutics Inc. | 6 | 2023-06-28 | 2025-10-20 |
| Prospective Observational Basket Study of Stereotactic Body Radiation Therapy for OligoMetastatic Patients From Rare Tumors SBRT - Oligometastatic Disease | Recruiting | Istituto Clinico Humanitas | 200 | 2023-06-09 | 2025-04-25 |
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Prostatic Neoplasms (9) · Carcinoma, Non-Small-Cell Lung (6) · Colorectal Neoplasms (6) · Neoplasm Metastasis (6) · Breast Neoplasms (3) · Esophageal Neoplasms (3) · Esophageal Squamous Cell Carcinoma (3) · Ovarian Neoplasms (2) · Stomach Neoplasms (2) · Adenocarcinoma (1) · Anus Neoplasms (1) · Carcinoma, Renal Cell (1) · Nasopharyngeal Carcinoma (1) · Neoplastic Cells, Circulating (1) · Pancreatic Neoplasms (1)
Neoplasms (36) · Neoplasms by Site (34) · Digestive System Diseases (15) · Digestive System Neoplasms (15) · Gastrointestinal Diseases (13) · Gastrointestinal Neoplasms (13) · Urogenital Diseases (13) · Urogenital Neoplasms (13) · Genital Diseases (11) · Male Urogenital Diseases (11) · Genital Diseases, Male (9) · Genital Neoplasms, Male (9) · Prostatic Diseases (9) · Intestinal Diseases (7) · Intestinal Neoplasms (7)
Radiosurgery (8) · Drug Therapy (4) · Abiraterone Acetate (3) · Androgen Antagonists (3) · Cisplatin (2) · Immune Checkpoint Inhibitors (2) · Metastasectomy (2) · Radiotherapy (2) · niraparib (2) · spartalizumab (2) · tislelizumab (2) · Ado-Trastuzumab Emtansine (1) · Albumin-Bound Paclitaxel (1) · Bevacizumab (1) · Chemoradiotherapy (1)
Cancer Institute and Hospital, Chinese Academy of Medical Sciences (3) · Fudan University (2) · Gitte Fredberg Persson MD PhD (2) · Sun Yat-sen University (2) · Tata Memorial Hospital (2) · Technische Universität Dresden (2) · University of Maryland, Baltimore (2) · Aarhus University Hospital (1) · Australasian Gastro-Intestinal Trials Group (1) · British Columbia Cancer Agency (1) · Case Comprehensive Cancer Center (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Gemelli Molise Hospital (1) · Good Samaritan Hospital Medical Center, New York (1)
China (12) · United States (10) · Italy (8) · Canada (3) · Denmark (3) · Germany (3) · Belgium (2) · India (2) · Ireland (2) · Netherlands (2) · Norway (2) · Russia (2) · Australia (1) · France (1) · Israel (1)
Barbro K Linderholm, MD, PhD (1) · Dirk Waldschmidt (1) · Dr. Anil Tibdewal (1) · Dr. Anil Tibdewal, MD (1) · Dr. Elliot Wakeam (1) · Fabio Arcidiacono, MD (1) · Fabio Trippa, MD (1) · Florian Gebauer, MD (1) · Gabriella Macchia (1) · Gitte F Persson, MD PhD (1) · Gitte Persson (1) · Guus Bol, Dr. (1)
PMID 19403881, PMID 27441744, PMID 28973074, PMID 30982687, PMID 31067138, PMID 31908301, PMID 32388150, PMID 32484754, PMID 32822540, PMID 34155084, PMID 34430382, PMID 35094066, PMID 35243022, PMID 36288758, PMID 36358757, PMID 36503429, PMID 37105304, PMID 37435562, PMID 37451182, PMID 37858132, PMID 38310262, PMID 40174649, PMID 40714134, PMID 40734507, PMID 42389925, PMID 42727887
2019 (1), P30CA046934 (1)