2 completed, 2 recruiting, 1 active not recruiting. 1 Not applicable, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 1 | Recruiting 1 |
| Phase 2 | 1 | Active not recruiting 1 |
Follow Nonfluent Variant Primary Progressive Aphasia (nfvPPA): new trials by email Literature Review of Nonfluent Variant Primary Progressive Aphasia (nfvPPA) trials Research Report on Nonfluent Variant Primary Progressive Aphasia (nfvPPA)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intervention for Communication Quality of Life in Primary Progressive Aphasia Multicomponent Lexical Retrieval Cascade Training, Multicomponent Video Implemented Script Training in Aphasia - Primary Progressive Aphasia(PPA), Semantic Dementia | Not applicable | Recruiting | Maya Henry | 30 | 2026-04-01 | 2026-04-21 |
| Clinical Study of Neflamapimod in Patients With Primary Progressive Aphasia Neflamapimod, Placebo - Nonfluent Variant Primary Progressive Aphasia (nfvPPA) | Phase 2 | Active not recruiting | EIP Pharma Inc | 20 | 2025-10-02 | 2026-07-06 |
| ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) Frontotemporal Lobar Degeneration (FTLD), Progressive Supranuclear Palsy (PSP) | Recruiting | Mayo Clinic | 2100 | 2020-03-01 | 2026-10-07 | |
| 4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2 Observational Study - Corticobasal Degeneration (CBD), Corticobasal Syndrome (CBS) | Completed | University of California, San Francisco | 293 | 2016-01-01 | 2025-04-13 | |
| Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) FTLD, Progressive Supranuclear Palsy (PSP) | Completed | University of California, San Francisco | 1489 | 2014-09-01 | 2021-05-21 |
Frontotemporal Dementia (4) · Corticobasal Degeneration (3) · Supranuclear Palsy, Progressive (3) · Amyotrophic Lateral Sclerosis (2) · Aphasia (2) · Aphasia, Primary Progressive (2) · Frontotemporal Lobar Degeneration (2) · Neurodegenerative Diseases (2) · Primary Progressive Nonfluent Aphasia (2) · Brain Diseases (1) · Central Nervous System Diseases (1) · Color Vision Defects (1) · Frontotemporal Dementia With Motor Neuron Disease (1) · Language Disorders (1) · Mental Disorders (1)
Dementia (5) · Neurologic Manifestations (5) · Pathological Conditions, Signs and Symptoms (5) · Signs and Symptoms (5) · Brain Diseases (4) · Central Nervous System Diseases (4) · Mental Disorders (4) · Metabolic Diseases (4) · Nervous System Diseases (4) · Neurocognitive Disorders (4) · Nutritional and Metabolic Diseases (4) · Proteostasis Deficiencies (4) · TDP-43 Proteinopathies (4) · Basal Ganglia Diseases (3) · Communication Disorders (3)
Observation (1)
University of California, San Francisco (2) · EIP Pharma Inc (1) · Maya Henry (1) · Mayo Clinic (1)
United States (5) · Canada (3) · United Kingdom (1)
Adam L Boxer, MD, PhD (2) · Adam Boxer, MD, PhD (1) · Bradley Boeve, MD (1) · Howie Rosen, MD (1) · Maya L Henry, PhD (1) · Stephanie M Grasso, PhD (1)
PMID 35790423, PMID 33827960, PMID 35492244, PMID 38578117, PMID 38959435
R01AG038791 (1), U19AG063911 (1), U54NS092089 (1)