12 recruiting, 8 not yet recruiting, 3 unknown, 1 active not recruiting. 12 Phase 2, 2 Not applicable, 2 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 12 | Recruiting 7, Not yet recruiting 4, Active not recruiting 1 |
| Not applicable | 2 | Not yet recruiting 1, Recruiting 1 |
| Phase 3 | 2 | Not yet recruiting 1, Recruiting 1 |
| Phase 1 | 1 | Recruiting 1 |
Follow Neoadjuvant Chemoimmunotherapy: new trials by email Literature Review of Neoadjuvant Chemoimmunotherapy trials Research Report on Neoadjuvant Chemoimmunotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Microbiota in Neoadjuvant Chemoimmunotherapy for NSCLC Neoadjuvant chemoimmunotherapy - Non-Small Cell Carcinoma of Lung, Gut Microbiomes | Not yet recruiting | Guangdong Provincial People's Hospital | 100 | 2026-07-31 | 2026-08-07 | |
| Phase II Trial of SFRT Plus Chemo-immunotherapy for LA-NSCLC With Suboptimal Neoadjuvant Response lattice radiation therapy - Locally Advanced Non-small Cell Lung Cancer (NSCLC), Thoracic Radiotherapy | Phase 2 | Not yet recruiting | Tianjin Medical University Cancer Institute and Hospital | 30 | 2026-07-01 | 2026-06-26 |
| Neoadjuvant SF-SBRT Plus Toripalimab and Chemotherapy in Resectable Stage II-III NSCLC. Stereotactic body radiotherapy (SBRT), neoadjuvant immunotherapy, Neoadjuvant Chemotherapy - Non Small Cell Lung Cancer, Stereotactic Body Radiotherapy | Phase 3 | Not yet recruiting | Shanghai Pulmonary Hospital, Shanghai, China | 201 | 2026-05-01 | 2026-05-29 |
| Neoadjuvant Iparomlimab/Tuvonralimab Plus CAPEOX Versus Iparomlimab/Tuvonralimab Plus CAPEOX and Propranolol for Locally Advanced pMMR Colon Cancer: A Prospective, Single-Center, Multi-Cohort Study Iparomlimab/Tuvonralimab, Capecitabine, Oxaliplatin - Colon Cancer (Stage II &Amp; III), Immunotherapy | Phase 2 | Not yet recruiting | Sun Yat-sen University | 45 | 2026-04-20 | 2026-04-24 |
| RATS Sleeve Lobectomy After Neo-Chemo-IO for NSCLC Robot-assisted thoracoscopic surgery (RATS) sleeve lobectomy - Stage IIB-III NSCLC, Sleeve Lobectomy | Recruiting | Shanghai Chest Hospital | 100 | 2026-04-13 | 2026-04-21 | |
| Simplified Exercise-based Risk Assessment in Lung Cancer Lung Cancer (Diagnosis), Lobectomy | Not yet recruiting | Linkoeping University | 500 | 2026-04-01 | 2026-04-08 | |
| Downstaging and RATS After Neo-Chemo-IO: Impact on Surgical Outcomes in NSCLC Robotic-assisted surgery (RATS) - Neoadjuvant Chemoimmunotherapy, Robotic Pulmonary Resection | Recruiting | Shanghai Chest Hospital | 200 | 2026-03-02 | 2026-04-14 | |
| Imaging-based PRediction of Eligibility for ChemoImmunotherapy in reSEctable NSCLC, iPRECISE High-resolution deep learning-based CT reconstruction - NSCLC, Neoadjuvant Chemoimmunotherapy | Recruiting | Samsung Medical Center | 150 | 2026-02-01 | 2026-05-08 | |
| Neoadjuvant Immunochemotherapy and Postoperative Adjuvant Immunotherapy for Head and Neck Squamous Cell Carcinoma Invading the Skull Base Neoadjuvant chemoimmunotherapy, Tislelizumab Nab paclitaxel - Head and Neck Cancer Squamous Cell Carcinoma, Skull Base--Cancer | Phase 2 | Not yet recruiting | Sun Yat-sen University | 24 | 2025-09-20 | 2025-08-28 |
| Tumor Margin Skin Tattooing Before Neo-adjuvant Chemotherapy in Patients With Breast Cancer Skin Tattooing of Tumor Margins Prior to Neoadjuvant Chemotherapy in Breast Cancer Patients: Prospective cohort study - Breast Cancer (Locally Advanced or Metastatic), Tattoo Skin Markers | Not applicable | Recruiting | All India Institute of Medical Sciences, Bhubaneswar | 30 | 2025-09-10 | 2026-03-18 |
| Adebrelimab Combined With Carboplatin and Albumin-bound Taxanol in the Treatment of Resectable Locally Advanced Oral Squamous Cell Carcinoma Cardiac, Randomized, Phase II Exploratory Study Preoperative neoadjuvant immunotherapy chemotherapy, Two courses of preoperative neoadjuvant immunotherapy chemotherapy, Three courses of preoperative neoadjuvant immunotherapy chemotherapy - Oral Squamous Cell Carcinoma (OSCC), Neoadjuvant Chemoimmunotherapy | Phase 2 | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 70 | 2025-08-15 | 2025-08-22 |
| Pucotenlimab Combined With Chemotherapy as Perioperative Treatment for Locally Advanced Gastroesophageal Junction Carcinoma Neoadjuvant chemo-immunotherapy - Gastroesophageal Junction, Gastric / Gastroesophageal Junction Adenocarcinoma | Not applicable | Not yet recruiting | Tang-Du Hospital | 30 | 2025-08-01 | 2025-07-29 |
| Neoadjuvant Radiotherapy Plus Tegafur, Oxaliplatin and Iparomlimab and Tuvonralimab in Resectable Gastric and GE-junction Cancer : A Randomized, Two-arm, Prospective Trial (TRIUNITE-05) Iparomlimab and Tuvonralimab, Oxaliplatin, Tegafur - Immunotherapy, Gastric Cancer (GC) | Phase 2 | Recruiting | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | 40 | 2025-07-23 | 2025-09-10 |
| NEoadjuvant Chemotherapy and Immunotherapy for a Selected Group of Inoperable Pleural Mesothelioma Patients (NECIM): a Feasibility Study Neoadjuvant chemo-immunotherapy, Extended pleurectomy/decortication in case of reaching operability - Pleural Epithelioid Mesothelioma, Mesothelioma; Pleura | Phase 1 / Phase 2 | Recruiting | University Hospital, Antwerp | 37 | 2025-07-22 | 2025-08-13 |
| Neoadjuvant Immunochemotherapy in PD-L1-negative LACC Camrelizumab, Paclitaxel-albumin, Cisplatin - Cervical Cancer, Locally Advanced Cervical Cancer | Phase 2 | Recruiting | Tongji Hospital | 40 | 2024-09-12 | 2025-03-20 |
| Neoadjuvant Chemoimmunotherapy and Extrafascial Hysterectomy for IB2 Cervical Cancer Cadonilimab, Paclitaxel-albumin, Cisplatin - Cervical Cancer, Neoadjuvant Chemoimmunotherapy | Phase 2 | Recruiting | Tongji Hospital | 50 | 2024-09-03 | 2024-09-19 |
| Neoadjuvant Chemotherapy Plus Camrelizumab for FIGO Stage IB1 Cervical Cancer Camrelizumab, Cisplatin, Nab paclitaxel - Cervical Cancer, Neoadjuvant Chemoimmunotherapy | Phase 2 | Recruiting | Tongji Hospital | 40 | 2024-05-08 | 2024-11-05 |
| Neoadjuvant Chemoimmunotherapy Versus Concurrent Chemoradiotherapy for LACC Camrelizumab, Cisplatin, Nab paclitaxel - Cervical Cancer, Locally Advanced Cervical Cancer | Phase 2 / Phase 3 | Recruiting | Tongji Hospital | 440 | 2024-04-22 | 2024-10-30 |
| Deep Learning Model Predicts Pathological Complete Response of Lung Cancer Following Neoadjuvant Immunochemotherapy No interventions - Deep Learning Model, Pathological Complete Response | Unknown | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 1000 | 2024-03-01 | 2024-03-13 | |
| Mechanism Study to Investigate Difference in Efficacy of Neoadjuvant Chemoimmunotherapy in Lung Squamous Cell Carcinoma Pathological response assessment - Tumor Microenvironment, Lung Squamous Cell Carcinoma | Unknown | Tang-Du Hospital | 40 | 2024-01-24 | 2024-05-30 |
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Carcinoma, Non-Small-Cell Lung (4) · Uterine Cervical Neoplasms (4) · Esophageal Squamous Cell Carcinoma (2) · Breast Neoplasms (1) · Colonic Neoplasms (1) · Disease (1) · Lung Neoplasms (1) · Mesothelioma, Malignant (1) · Motor Activity (1) · Neoplasm Metastasis (1) · Pathologic Complete Response (1) · Rectal Neoplasms (1) · Squamous Cell Carcinoma of Head and Neck (1) · Stomach Neoplasms (1)
Neoplasms (17) · Neoplasms by Site (17) · Lung Diseases (6) · Respiratory Tract Diseases (6) · Respiratory Tract Neoplasms (6) · Thoracic Neoplasms (6) · Digestive System Diseases (5) · Digestive System Neoplasms (5) · Gastrointestinal Diseases (5) · Gastrointestinal Neoplasms (5) · Lung Neoplasms (5) · Bronchial Neoplasms (4) · Carcinoma, Bronchogenic (4) · Female Urogenital Diseases (4) · Female Urogenital Diseases and Pregnancy Complications (4)
Cisplatin (5) · camrelizumab (3) · Oxaliplatin (2) · Taxes (2) · Albumin-Bound Paclitaxel (1) · Biopsy (1) · Brachytherapy (1) · Capecitabine (1) · Carboplatin (1) · Cerebral Decortication (1) · Conization (1) · Drug Therapy (1) · Neoadjuvant Therapy (1) · Propranolol (1) · Radiosurgery (1)
Tongji Hospital (4) · Shanghai Chest Hospital (2) · Shanghai Pulmonary Hospital, Shanghai, China (2) · Sun Yat-sen University (2) · Tang-Du Hospital (2) · All India Institute of Medical Sciences, Bhubaneswar (1) · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University (1) · Guangdong Provincial People's Hospital (1) · Guo Xufeng (1) · Linkoeping University (1) · Samsung Medical Center (1) · Shanghai Zhongshan Hospital (1) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (1) · The First Affiliated Hospital of Anhui Medical University (1) · Tianjin Medical University Cancer Institute and Hospital (1)
China (15) · France (2) · Italy (2) · Belgium (1) · India (1) · South Korea (1) · Sweden (1)
Ding Ma (4) · Bin Wang (1) · Changqing Pan (1) · Di Ge, MD (1) · Kristofer Hedman, MD, PhD (1) · Yujie Liang (1) · Zhigang Li, MD, PhD (1)
PMID 15825201, PMID 18486742, PMID 18784101, PMID 23129742, PMID 24419108, PMID 27718784, PMID 30509740, PMID 31679945, PMID 33243985, PMID 34160577, PMID 34473219, PMID 35403841, PMID 35585121, PMID 35766967, PMID 37395170, PMID 37991778, PMID 38110599, PMID 38467604, PMID 38512301, PMID 41127561, PMID 41582028, PMID 42172490
2023 (1), 2025 (1)