5 completed, 2 recruiting, 1 active not recruiting, 1 terminated. 5 Phase 2, 3 Phase 4, 1 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 2, Active not recruiting 1, Terminated 1, Withdrawn 1 |
| Phase 4 | 3 | Completed 2, Recruiting 1 |
| Not applicable | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Mycobacterium Avium Complex: new trials by email Literature Review of Mycobacterium Avium Complex trials Research Report on Mycobacterium Avium Complex
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Drug Exposure and Minimum Inhibitory Concentration in the Treatment of MAC Lung Disease Drug exposure - Mycobacterium Avium Complex, Mycobacterium Avium-Intracellulare Infection | Recruiting | Shanghai Pulmonary Hospital, Shanghai, China | 100 | 2023-04-14 | 2024-01-22 | |
| Hypertonic Saline Inhalation for Mycobacterium Avium Complex Pulmonary Disease Hypertonic Saline inhalation - Nontuberculous Mycobacterial Lung Disease, Mycobacterium Avium Complex | Phase 4 | Recruiting | Radboud University Medical Center | 30 | 2022-05-20 | 2026-09-15 |
| A Pilot Study to Assess the Effect of Intermittent iNO on the Treatment of NTM Lung Infection in CF and Non-CF Patients LungFit - Non-Tuberculous Mycobacterial Pneumonia, Cystic Fibrosis | Not applicable | Completed | Beyond Air Inc. | 15 | 2020-12-07 | 2022-12-16 |
| Safety, Tolerability, Pharmacokinetics and Efficacy of SPR720 for the Treatment of Patients With Mycobacterium Avium Complex (MAC) Pulmonary Disease SPR720, Placebo, Open-label Standard of Care - Mycobacterium Avium Complex, Non-tuberculous Mycobacterium Pulmonary Disease | Phase 2 | Terminated | Spero Therapeutics | 2 | 2020-12-03 | 2022-02-28 |
| A Study of Standard Drugs for Mycobacterium Avium Complex Azithromycin - Mycobacterium Avium Complex | Phase 2 | Completed | Johns Hopkins University | 10 | 2020-02-24 | 2026-07-15 |
| Comparison of Two- Versus Three-antibiotic Therapy for Pulmonary Mycobacterium Avium Complex Disease Azithromycin, Ethambutol, Rifampin - Mycobacterium Avium Complex, Nontuberculous Mycobacterium Infection | Phase 2 / Phase 3 | Completed | Kevin Winthrop | 474 | 2019-02-22 | 2026-02-02 |
| Clofazimine in the Treatment of Pulmonary Mycobacterium Avium Complex (MAC) Clofazimine, sugar pill - Mycobacterium Avium Complex | Phase 2 | Active not recruiting | Oregon Health and Science University | 102 | 2017-04-11 | 2026-05-06 |
| Improving Tolerance of Treatment of Pulmonary MAC Infections Zofran (8mg), Ensure - Mycobacterium Avium Complex, Adverse Effects | Phase 2 | Withdrawn | University of Florida | 2013-01-01 | 2013-04-04 | |
| Use of Azithromycin and Rifabutin Administered 3 Times Weekly for the Treatment of M. Avium Complex (MAC) Lung Disease Azithromycin, Rifabutin/rifampin - Mycobacterium Avium Complex | Phase 4 | Completed | The University of Texas Health Science Center at Tyler | 58 | 1994-12-01 | 2017-05-23 |
| Clarithromycin for the Treatment of Infections Caused by Nontuberculous Mycobacteria (NTM) Clarithromycin - Nontuberculous Mycobacteria, Mycobacterium Avium Complex | Phase 4 | Completed | The University of Texas Health Science Center at Tyler | 210 | 1991-01-01 | 2017-05-23 |
Mycobacterium avium-intracellulare Infection (10) · Mycobacterium Infections (2) · Mycobacterium Infections, Nontuberculous (2) · Cystic Fibrosis (1) · Gram-Positive Bacterial Infections (1)
Actinomycetales Infections (10) · Bacterial Infections (10) · Bacterial Infections and Mycoses (10) · Infections (10) · Gram-Positive Bacterial Infections (9) · Mycobacterium Infections (8) · Mycobacterium Infections, Nontuberculous (8) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Digestive System Diseases (1) · Genetic Diseases, Inborn (1) · Infant, Newborn, Diseases (1) · Lung Diseases (1) · Pancreatic Diseases (1) · Respiratory Tract Diseases (1)
Azithromycin (3) · Rifampin (2) · Clarithromycin (1) · Clofazimine (1) · Ensure Plus (1) · Ethambutol (1) · Ondansetron (1) · Rifabutin (1) · Sugars (1)
The University of Texas Health Science Center at Tyler (2) · Beyond Air Inc. (1) · Johns Hopkins University (1) · Kevin Winthrop (1) · Oregon Health and Science University (1) · Radboud University Medical Center (1) · Shanghai Pulmonary Hospital, Shanghai, China (1) · Spero Therapeutics (1) · University of Florida (1)
United States (6) · Australia (1) · Canada (1) · China (1) · Netherlands (1)
Biao Xu, Prof (1) · David Melnick, MD (1) · Elisa H Ignatius, MD (1) · Emily Henkle, PhD, MPH (1) · Jan-Willem Alffenaar, PhamD, Prof (1) · Judith Bruchfeld, Ass. Prof (1) · Kevin L Winthrop, MD, MPH (1) · Kevin P Fennelly, MD, MPH (1) · Kevin Winthrop, MD (1) · Lina Davies Forsman, MD, PhD (1) · Richard J Wallace Jr., M.D. (1) · Richard J Wallace, MD (1) · Wei Sha, MD, Prof (1) · Xubin Zheng, MPH, PhD (1) · Yangyi Zhang, MPH (1)
K23AI159145 (1)