6 recruiting, 2 completed, 2 not yet recruiting, 1 suspended. 4 Not applicable, 3 Phase 1, 2 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Completed 2, Not yet recruiting 1, Recruiting 1 |
| Phase 1 | 3 | Recruiting 3 |
| Phase 2 | 2 | Not yet recruiting 1, Recruiting 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Multiple Sclerosis (MS) Primary Progressive: new trials by email Literature Review of Multiple Sclerosis (MS) Primary Progressive trials Research Report on Multiple Sclerosis (MS) Primary Progressive
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Remibrutinib Using MR Imaging in Relapsing or Progressive MS Remibrutinib (Open Label) - Multiple Sclerosis (MS) - Relapsing-remitting, Multiple Sclerosis (MS) Secondary Progressive | Phase 2 | Not yet recruiting | Moein Amin | 20 | 2027-03-01 | 2026-08-19 |
| Acute Intermittent Hypoxia Combined With Gait Training in Multiple Sclerosis Acute Intermittent Hypoxia (AIH), Sham Acute Intermittent Hypoxia (AIH), Myoelectric Interface Neurorehabilitation Training (MINT) - Multiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting | Not applicable | Not yet recruiting | Shirley Ryan AbilityLab | 35 | 2026-06-15 | 2026-06-08 |
| Safety and Efficacy of S103 Cells in Progressive/Refractory Multiple Sclerosis S103 cells - Multiple Sclerosis (MS) Primary Progressive, Multiple Sclerosis | Phase 1 | Recruiting | Xijing Hospital | 9 | 2026-05-08 | 2026-08-05 |
| A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis Orelabrutinib, Placebo - Multiple Sclerosis (MS) Primary Progressive | Phase 3 | Recruiting | Zenas BioPharma (USA), LLC | 705 | 2026-03-23 | 2026-10-20 |
| Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis TRX319, Bendamustine - Primary Progressive Multiple Sclerosis, Secondary Progressive Multiple Sclerosis (SPMS) | Phase 1 / Phase 2 | Recruiting | Tr1X, Inc. | 39 | 2026-03-01 | 2026-09-21 |
| Home Based Functional Balance Intervention for Multiple Sclerosis Multicomponent balance intervention consisting of four components including dual-tasking, functional strength, vestibular and dynamic balance., Stretching - Multiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting | Not applicable | Recruiting | University of Illinois at Chicago | 75 | 2025-11-24 | 2026-01-21 |
| "Selfie" Videos: A Novel, Patient-centered, Comprehensive Approach to Measuring Function in MS Multiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting | Recruiting | University of California, San Francisco | 300 | 2025-10-01 | 2025-10-31 | |
| Phase 1 Study of HBI0101 CAR-T in Refractory B-Cell Autoimmune Diseases HBI0101 CART - Systemic Sclerosis (SSc), Idiopathic Inflammatory Myopathy (IIM) | Phase 1 | Recruiting | Polina Stepensky | 120 | 2024-09-01 | 2026-05-06 |
| Transcranial Direct Current Stimulation for Fatigue, Mood, and Cognition in Multiple Sclerosis Transcranial Direct Current Stimulation, Sham transcranial direct current stimulation simulation - Multiple Sclerosis, MS, Multiple Sclerosis | Not applicable | Completed | Universidad de Almeria | 38 | 2023-08-01 | 2026-07-02 |
| A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease There is no intervention in this study - Gut Microbiome, Gastrointestinal Microbiome | Suspended | ProgenaBiome | 1000 | 2019-07-11 | 2026-09-21 | |
| Social Cognition in Multiple Sclerosis, From a Study of Eye Movement and Gaze Strategies Using Video-oculography Video-oculography / Social cognition tasks / Neuropsychological evaluations - Multiple Sclerosis (MS), Multiple Sclerosis (MS) Relapsing Remitting | Not applicable | Completed | Association de Recherche Bibliographique pour les Neurosciences | 76 | 2017-05-23 | 2021-01-22 |
Multiple Sclerosis, Chronic Progressive (11) · Multiple Sclerosis (10) · Multiple Sclerosis, Relapsing-Remitting (7) · Arthritis, Rheumatoid (2) · Myasthenia Gravis (2) · Acne Vulgaris (1) · Alzheimer Disease (1) · Amyotrophic Lateral Sclerosis (1) · Antiphospholipid Syndrome (1) · Anxiety Disorders (1) · Autism Spectrum Disorder (1) · Autistic Disorder (1) · Bipolar Disorder (1) · Bipolar and Related Disorders (1) · Celiac Disease (1)
Autoimmune Diseases (11) · Autoimmune Diseases of the Nervous System (11) · Chronic Disease (11) · Demyelinating Autoimmune Diseases, CNS (11) · Disease Attributes (11) · Immune System Diseases (11) · Nervous System Diseases (11) · Pathologic Processes (11) · Pathological Conditions, Signs and Symptoms (11) · Demyelinating Diseases (10) · Signs and Symptoms (3) · Arthritis (2) · Connective Tissue Diseases (2) · Joint Diseases (2) · Mental Disorders (2)
Bendamustine Hydrochloride (1) · Transcranial Direct Current Stimulation (1) · orelabrutinib (1) · remibrutinib (1)
Association de Recherche Bibliographique pour les Neurosciences (1) · Moein Amin (1) · Polina Stepensky (1) · ProgenaBiome (1) · Shirley Ryan AbilityLab (1) · Tr1X, Inc. (1) · Universidad de Almeria (1) · University of California, San Francisco (1) · University of Illinois at Chicago (1) · Xijing Hospital (1) · Zenas BioPharma (USA), LLC (1)
United States (6) · Bulgaria (1) · China (1) · Croatia (1) · Czechia (1) · Estonia (1) · Georgia (1) · Germany (1) · Israel (1) · Italy (1) · Mexico (1) · Monaco (1) · Netherlands (1) · Poland (1) · Puerto Rico (1)
Milap Sandhu, PT, PhD (1) · Moein Amin, MD, MS (1) · Riley Bove, MD (1) · Sabine Hazan, MD (1)