6 completed, 2 terminated, 1 withdrawn. 6 Phase 1, 3 Phase 2, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Completed 6 |
| Phase 2 | 3 | Terminated 2, Completed 1 |
| Early Phase 1 | 1 | Withdrawn 1 |
Follow Mixed Glioma: new trials by email Literature Review of Mixed Glioma trials Research Report on Mixed Glioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Autologous Stem Cell Collection and Reinfusion in Newly Diagnosed High Grade Gliomas Radiation therapy, Temozolomide, Stem cell collection - Astrocytoma, Brainstem Glioma | Early Phase 1 | Withdrawn | Washington University School of Medicine | 2017-01-01 | 2017-02-20 | |
| Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma Laboratory Biomarker Analysis, Lapatinib, Lapatinib Ditosylate - Anaplastic Astrocytoma, Anaplastic Ependymoma | Phase 1 | Completed | National Cancer Institute (NCI) | 29 | 2016-11-07 | 2024-11-06 |
| Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors MRI-guided laser ablation, Doxorubicin, Etoposide - Glioma, Pilocytic Astrocytoma | Phase 2 | Terminated | Washington University School of Medicine | 6 | 2015-08-14 | 2024-11-01 |
| Perifosine and Torisel (Temsirolimus) for Recurrent/Progressive Malignant Gliomas Cytoreductive surgery, Perifosine, Temsirolimus - Brain Tumor, Recurrent, Glioblastoma | Phase 1 | Completed | Andrew B Lassman, MD | 10 | 2014-12-08 | 2023-05-25 |
| Vaccine Therapy and Sargramostim in Treating Patients With Malignant Glioma Laboratory Biomarker Analysis, Montanide ISA-51/Survivin Peptide Vaccine, Sargramostim - Anaplastic Astrocytoma, Anaplastic Oligoastrocytoma | Phase 1 | Completed | Roswell Park Cancer Institute | 9 | 2012-09-05 | 2017-02-27 |
| Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2 therapeutic allogeneic lymphocytes, aldesleukin, laboratory biomarker analysis - Anaplastic Astrocytoma, Anaplastic Ependymoma | Phase 1 | Completed | City of Hope Medical Center | 6 | 2011-03-22 | 2026-10-19 |
| Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade Glioma ritonavir, lopinavir - Brain Tumor, Anaplastic Astrocytoma | Phase 2 | Terminated | Case Comprehensive Cancer Center | 19 | 2009-01-01 | 2013-06-10 |
| Viral Therapy in Treating Patients With Recurrent Glioblastoma Multiforme Carcinoembryonic Antigen-Expressing Measles Virus, Laboratory Biomarker Analysis, Therapeutic Conventional Surgery - Anaplastic Astrocytoma, Anaplastic Oligodendroglioma | Phase 1 | Completed | Mayo Clinic | 23 | 2006-10-23 | 2020-01-02 |
| Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors Carboplatin, Etoposide, Etoposide Phosphate - Anaplastic Oligoastrocytoma, Anaplastic Oligodendroglioma | Phase 1 / Phase 2 | Completed | OHSU Knight Cancer Institute | 33 | 2005-09-15 | 2022-03-17 |
Astrocytoma (9) · Glioma (9) · Oligodendroglioma (9) · Glioblastoma (7) · Brain Neoplasms (5) · Ependymoma (4) · Gliosarcoma (4) · Optic Nerve Glioma (2) · Meningioma (1) · Neuroectodermal Tumors, Primitive (1)
Neoplasms (9) · Neoplasms by Histologic Type (9) · Neoplasms, Germ Cell and Embryonal (9) · Neoplasms, Glandular and Epithelial (9) · Neoplasms, Nerve Tissue (9) · Neoplasms, Neuroepithelial (9) · Neuroectodermal Tumors (9) · Neoplasms by Site (7) · Nervous System Diseases (7) · Nervous System Neoplasms (7) · Brain Diseases (5) · Central Nervous System Diseases (5) · Central Nervous System Neoplasms (5) · Cranial Nerve Diseases (2) · Cranial Nerve Neoplasms (2)
Etoposide (2) · etoposide phosphate (2) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · Carboplatin (1) · Colony-Stimulating Factors (1) · Cytoreduction Surgical Procedures (1) · Doxorubicin (1) · Dynamic Contrast Enhanced Magnetic Resonance Imaging (1) · Interleukin-2 (1) · Interleukins (1) · Lapatinib (1) · Lopinavir (1) · Magnetic Resonance Spectroscopy (1) · Mannitol (1) · Melphalan (1)
Washington University School of Medicine (2) · Andrew B Lassman, MD (1) · Case Comprehensive Cancer Center (1) · City of Hope Medical Center (1) · Mayo Clinic (1) · National Cancer Institute (NCI) (1) · OHSU Knight Cancer Institute (1) · Roswell Park Cancer Institute (1)
United States (8)
Andrew B. Lassman, MD (1) · Andrew Cluster, M.D. (1) · Behnam Badie (1) · David Peereboom, MD (1) · Edward A Neuwelt (1) · Evanthia Galanis (1) · Jian Li Campian, M.D., Ph.D. (1) · Robert Fenstermaker (1) · Timothy F Cloughesy (1)
P30CA015083 (1), P30CA016056 (1), P50CA108961 (1), U01CA137443 (1), UM1CA137443 (1)