9 completed, 3 terminated, 1 not yet recruiting. 7 Phase 1, 6 Phase 2, 2 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 6, Terminated 1 |
| Phase 2 | 6 | Completed 4, Not yet recruiting 1, Terminated 1 |
| Phase 3 | 2 | Not yet recruiting 1, Terminated 1 |
| Phase 4 | 1 | Terminated 1 |
Follow Interleukins: new trials by email Literature Review of Interleukins trials Research Report on Interleukins
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Immunoglobulin Plus Firsekibart in Patients With Kawasaki Disease IVIG, Aspirin, Firsekibart - Kawasaki Disease | Phase 2 / Phase 3 | Not yet recruiting | Children's Hospital of Fudan University | 90 | 2026-11-01 | 2026-10-22 |
| Relaxin, Matrix Metalloproteinase-2 and Interleukin-6 in Women With Chronic Pelvic Pain interleukin, enzyme, hormone - Endometriosis | Completed | Sanliurfa Mehmet Akif Inan Education and Research Hospital | 60 | 2022-06-15 | 2024-10-08 | |
| Combined Sertraline and Ketoprofen Administration in Major Depressive Disorder Combined Sertraline & Ketoprofen, Interleukins in MDD after treatment - Major Depressive Disorder | Phase 1 | Completed | Kufa University | 28 | 2017-01-10 | 2018-05-03 |
| Cytokine-induced Memory-like NK Cells in Patients With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) Fludarabine, Cyclophosphamide, Leukapheresis - Leukemia, Myeloid, Acute | Phase 1 / Phase 2 | Terminated | Washington University School of Medicine | 89 | 2014-08-11 | 2024-01-17 |
| Tumor-Infiltrating Lymphocytes And Low-Dose Interleukin-2 Therapy Following Cyclophosphamide And Fludarabine In Patients With Melanoma Cyclophosphamide, Fludarabine, Tumor-Infiltrating Lymphocytes - Metastatic, Stage III or Stage IV, Melanoma | Phase 2 | Completed | University Health Network, Toronto | 12 | 2013-06-01 | 2019-11-08 |
| HD IL-2 + Ipilimumab in Patients With Metastatic Melanoma High Dose Interleukin-2, Ipilimumab - Metastatic Melanoma | Phase 4 | Terminated | Clinigen, Inc. | 29 | 2013-05-01 | 2023-12-05 |
| Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2 therapeutic allogeneic lymphocytes, aldesleukin, laboratory biomarker analysis - Anaplastic Astrocytoma, Anaplastic Ependymoma | Phase 1 | Completed | City of Hope Medical Center | 6 | 2011-03-22 | 2026-10-19 |
| Safety and Efficacy Study of Immunotherapy With Rituximab and Interleukin-2 in Patients With Non-Hodgkin's Lymphoma Rituximab, Interleukin-2 - High Risk Non-Hodgkin's Lymphoma | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 11 | 2009-02-05 | 2025-04-30 |
| Laboratory-Treated T Cells and Aldesleukin After Cyclophosphamide in Treating Patients With Stage IV Melanoma therapeutic autologous lymphocytes, aldesleukin, cyclophosphamide - Recurrent Melanoma, Stage IV Melanoma | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 10 | 2007-09-01 | 2017-02-15 |
| A Pilot Study of Autologous Ex Vivo Activated NK Cell Infusion in the Treatment of Metastatic Nasopharyngeal Carcinoma Interleukin, NK cells - Metastatic Nasopharyngeal | Phase 1 | Completed | National University Hospital, Singapore | 2007-05-01 | 2010-04-09 | |
| Combined Treatment With Capecitabine and Immunotherapy Versus Immunotherapy Alone in Advanced Renal Cell Carcinoma Capecitabine, Interferon, Interleukin - Renal Cell Cancer | Phase 3 | Terminated | Central European Cooperative Oncology Group | 172 | 2004-03-01 | 2012-05-16 |
| Study of KIR-Ligand Mismatched Haplo-Identical Natural Killer Cells Transfused Before Autologous Stem Cell Transplant Dexamethasone, Cyclophosphamide, Melphalan - Multiple Myeloma | Phase 1 | Completed | University of Arkansas | 10 | 2003-09-01 | 2012-04-19 |
| Immunotherapy After Chemotherapy for Patients With Hormone Refractory Metastatic Prostate Cancer docetaxel, IL2 - Prostate Cancer | Phase 1 / Phase 2 | Completed | University of Washington | 30 | 2002-09-01 | 2007-11-29 |
Melanoma (3) · Neoplasm Metastasis (2) · Astrocytoma (1) · Brain Neoplasms (1) · Carcinoma, Renal Cell (1) · Depressive Disorder, Major (1) · Endometriosis (1) · Ependymoma (1) · Glioblastoma (1) · Glioma (1) · Gliosarcoma (1) · Leukemia, Myeloid, Acute (1) · Lymphoma (1) · Lymphoma, Non-Hodgkin (1) · Meningioma (1)
Central European Cooperative Oncology Group (1) · Children's Hospital of Fudan University (1) · City of Hope Medical Center (1) · Clinigen, Inc. (1) · Fred Hutchinson Cancer Center (1) · Kufa University (1) · National University Hospital, Singapore (1) · Sanliurfa Mehmet Akif Inan Education and Research Hospital (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · University Health Network, Toronto (1) · University of Arkansas (1) · University of Washington (1) · Washington University School of Medicine (1)
United States (7) · Austria (1) · Canada (1) · China (1) · Singapore (1) · Turkey (Türkiye) (1)
Alvin Seng Cheong Wong, MBBS, MRCP (1) · Amanda Cashen, M.D. (1) · Arafat H Al-dujaili, PhD (1) · Behnam Badie (1) · Butler Marcus, M.D. (1) · Cassian Yee (1) · Celestia Higano, MD (1) · Fang Liu, MD (1) · Frits Van Rhee, M.D., Ph.D. (1) · James Lowder, MD (1) · Manuela Schmidinger, Prof (1) · Matthew Carabasi, MD (1) · Sapna Patel, MD (1) · William Sharfman, MD (1)
PMID 30747243, PMID 34797911, PMID 41402893
F32CA200253 (1)