17 completed, 2 terminated, 1 unknown. 20 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 20 | Completed 17, Terminated 2, Unknown 1 |
| Phase 1 | 2 | Completed 2 |
Follow Methamphetamine Dependence: new trials by email Literature Review of Methamphetamine Dependence trials Research Report on Methamphetamine Dependence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trial of Ibudilast for Methamphetamine Dependence Ibudilast, Placebo - Methamphetamine Dependence, HIV Infection | Phase 2 | Completed | University of California, Los Angeles | 125 | 2013-07-01 | 2019-01-30 |
| Clinical Efficacy of Atomoxetine for Methamphetamine Dependence Atomoxetine, placebo - Methamphetamine Dependence | Phase 1 / Phase 2 | Completed | University of Arkansas | 20 | 2012-04-01 | 2017-02-09 |
| Varenicline for Methamphetamine Dependence Varenicline, Placebo - Methamphetamine Dependence, Substance Abuse | Phase 2 | Completed | University of California, Los Angeles | 52 | 2012-02-01 | 2018-01-18 |
| A Randomized, Placebo-Controlled Trial of Modafinil for Methamphetamine Dependence Modafinil - Methamphetamine Dependence | Phase 2 | Completed | California Pacific Medical Center Research Institute | 72 | 2011-10-01 | 2013-07-02 |
| PHASE IIA: Trial of a Novel Ondansetron Formulation (OND-PR002) and Immediate-Release Methylphenidate (Ritalin®)(OND003IND) OND-PR002 and MPh-IR, Placebo: Two dextrose capsules for Ond-PR002 and MPh-IR - Methamphetamine Dependence, Cocaine Dependence | Phase 2 | Completed | Tong Lee | 30 | 2011-08-01 | 2014-10-07 |
| Methylphenidate to Treat Methamphetamine Dependence methylphenidate, Methylphenidate - Methamphetamine Dependence | Phase 2 | Unknown | University of California, Los Angeles | 90 | 2010-10-01 | 2014-05-20 |
| Varenicline vs Placebo for the Treatment of Methamphetamine Dependence Varenicline, Placebo - Methamphetamine Dependence, Substance Abuse | Phase 2 | Completed | University of California, Los Angeles | 20 | 2009-11-01 | 2013-03-14 |
| Studying Amphetamine Withdrawal in Humans Dextroamphetamine, Placebo - Methamphetamine Dependence | Phase 2 | Completed | University of Arkansas | 35 | 2009-10-01 | 2014-08-04 |
| Study of Naltrexone for Methamphetamine Addiction Naltrexone - Methamphetamine Dependence | Phase 2 | Completed | California Pacific Medical Center Research Institute | 22 | 2009-09-01 | 2013-05-31 |
| Modafinil for Methamphetamine Dependence Modafinil, Placebo - Methamphetamine Dependence | Phase 2 | Terminated | University of Arkansas | 9 | 2009-04-01 | 2017-11-21 |
| Intensive Motivational Interviewing for Methamphetamine Dependence Intensive MI, Single session MI - Methamphetamine Dependence | Phase 2 | Completed | Public Health Institute, California | 217 | 2009-02-01 | 2018-05-24 |
| Study of Medical Treatment for Methamphetamine Addiction Bupropion - Methamphetamine, Amphetamine Dependence | Phase 2 | Completed | University of California, Los Angeles | 84 | 2009-01-01 | 2014-02-26 |
| Open-Label Disulfiram for Methamphetamine Dependence Disulfiram - Methamphetamine Dependence | Phase 1 / Phase 2 | Completed | University of Arkansas | 15 | 2008-08-01 | 2012-02-27 |
| Safety and Efficacy Study of Vigabatrin to Treat Methamphetamine Dependence CPP-109 vigabatrin, Matching Placebo - Methamphetamine Dependence | Phase 2 | Terminated | Catalyst Pharmaceuticals, Inc. | 55 | 2008-07-01 | 2020-12-09 |
| Phase 2, Double-Blind, Placebo-Controlled Trial of Bupropion for Methamphetamine Dependence Bupropion, Placebo - Methamphetamine Dependence | Phase 2 | Completed | National Institute on Drug Abuse (NIDA) | 200 | 2008-05-01 | 2017-03-21 |
| Phase 2, Multi-Center Trial of Modafinil for Methamphetamine Dependence Modafinil, Placebo - Methamphetamine Dependence | Phase 2 | Completed | National Institute on Drug Abuse (NIDA) | 210 | 2007-12-01 | 2017-04-07 |
| Safety and Tolerability of Modafinil for Methamphetamine Dependence Modafinil - Methamphetamine Dependence | Phase 2 | Completed | University of Arkansas | 8 | 2007-09-01 | 2010-10-05 |
| Modafinil vs Placebo for the Treatment of Methamphetamine Dependence Modafinil, Placebo - Methamphetamine Dependence | Phase 2 | Completed | University of California, Los Angeles | 71 | 2007-04-01 | 2020-03-02 |
| N-Acetyl Cysteine Plus Naltrexone in Methamphetamine Dependence Naltrexone plus N-Acetyl Cysteine, Placebo - Methamphetamine Dependence | Phase 2 | Completed | University of Chicago | 45 | 2006-06-01 | 2022-08-23 |
| A Trial of Long-Acting Injectable Risperidone in the Treatment of Methamphetamine Dependence long-acting injectable risperidone - Methamphetamine Dependence | Phase 2 | Completed | Seattle Institute for Biomedical and Clinical Research | 20 | 2006-01-01 | 2008-01-11 |
Behavior, Addictive (5) · Substance-Related Disorders (3) · Amphetamine-Related Disorders (1) · Cocaine-Related Disorders (1) · HIV Infections (1) · Recurrence (1)
Behavior (5) · Compulsive Behavior (5) · Impulsive Behavior (5) · Chemically-Induced Disorders (4) · Mental Disorders (4) · Blood-Borne Infections (1) · Communicable Diseases (1) · Disease Attributes (1) · Genital Diseases (1) · Immune System Diseases (1) · Immunologic Deficiency Syndromes (1) · Infections (1) · Lentivirus Infections (1) · Pathologic Processes (1) · Pathological Conditions, Signs and Symptoms (1)
Modafinil (5) · Sugars (4) · Bupropion (2) · Methylphenidate (2) · Naltrexone (2) · Varenicline (2) · Acetylcysteine (1) · Atomoxetine Hydrochloride (1) · Dextroamphetamine (1) · Disulfiram (1) · Ondansetron (1) · Vigabatrin (1) · ibudilast (1) · vivitrol (1)
University of California, Los Angeles (6) · University of Arkansas (5) · California Pacific Medical Center Research Institute (2) · National Institute on Drug Abuse (NIDA) (2) · Catalyst Pharmaceuticals, Inc. (1) · Public Health Institute, California (1) · Seattle Institute for Biomedical and Clinical Research (1) · Tong Lee (1) · University of Chicago (1)
United States (20)
Alison Oliveto, PhD (2) · Steven Shoptaw, PhD (2) · Ahmed Elkashef, M.D. (1) · Andrew J Saxon (1) · Ashwin A Patkar, MD (1) · Charles W Gorodetzky, MD, PhD (1) · Douglas Polcin, Ed.D. (1) · Dr. Janette McGaugh, MD (1) · Gantt Galloway, PharmD (1) · John Mendelson, MD (1) · Jon E Grant, MD, JD (1) · Jurij Mojsiak (1) · Keith G Heinzerling, MD MPH (1) · Keith Heinzerling, MD (1) · Maureen Hillhouse, Ph.D. (1)
PMID 20092966, PMID 21840138, PMID 22217949, PMID 22445683, PMID 24894963, PMID 29860057
P50DA018185 (3), P50DA018197 (2), 1RC2DA028905-01 (1), K23DA023558 (1), R01DA035054 (1)