12 completed, 7 active not recruiting, 7 terminated, 4 recruiting. 17 Phase 2, 9 Phase 1, 7 Not applicable, 4 Phase 3.
Follow Metastatic Malignant Neoplasm in the Bone: new trials by email Literature Review of Metastatic Malignant Neoplasm in the Bone trials Research Report on Metastatic Malignant Neoplasm in the Bone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intraoperative Neuromonitoring of Sacral Reflexes to Predict Post Operative Function in Patients Undergoing Sacrectomy for Pelvic Bone Malignancy or Patients Undergoing Spinal Procedures Without Sacral Root Involvement Intraoperative Nerve Monitoring, Surgical Procedure, Survey Administration - Bone Neoplasm, Metastatic Malignant Neoplasm in the Bone | Not applicable | Not yet recruiting | City of Hope Medical Center | 50 | 2027-01-10 | 2026-07-16 |
| Testing the Safety of the Anti-cancer Drug, Sn-117m-DTPA, for Advanced Cancers That Have Spread to Bones Biospecimen Collection, Bone Scan, Computed Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 1 | Withdrawn | National Cancer Institute (NCI) | 2026-10-01 | 2026-08-28 | |
| Comparing Radiation Therapy to Usual Treatment for Patients With High-Risk Bone Metastases That Are Not Causing Pain, PREEMPT Trial Best Practice, Biospecimen Collection, Bone Metastases Treatment - Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Solid Neoplasm | Phase 3 | Active not recruiting | NRG Oncology | 280 | 2025-05-07 | 2026-08-17 |
| Efficacy of Ra-223 in PSMA PET Optimally Selected Patients Radium-223, PSMA Positron Emission Tomography (PET) Scan, Technetium Tc 99M Medronate - Castration-Resistant Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone | Phase 2 | Active not recruiting | University of California, San Francisco | 2 | 2024-08-30 | 2026-01-14 |
| Biology-Guided Radiation Therapy for the Treatment of Patients With Bone Metastases Computed Tomography, Image Guided Radiation Therapy, Positron Emission Tomography - Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Solid Neoplasm | Phase 1 | Suspended | City of Hope Medical Center | 24 | 2024-08-25 | 2026-10-20 |
| BAY1895344 and Copanlisib for the Treatment of Molecularly Selected Patients With Advanced Solid Tumors Copanlisib, Elimusertib - Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Bone | Phase 1 | Withdrawn | M.D. Anderson Cancer Center | 2022-03-22 | 2022-05-27 | |
| Treatment of Cancer-Related Bone Pain by Using Bone-Targeted Radiation-Based Therapy (Sn-117m-DTPA) in Patients With Prostate Cancer That Has Spread to Bones Questionnaire Administration, Tin Sn 117m Pentetate - Castration-Resistant Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone | Phase 2 | Terminated | National Cancer Institute (NCI) | 1 | 2021-12-18 | 2025-10-03 |
| Erdafitinib for the Treatment of Patients With Castration-Resistant Prostate Cancer Biopsy, Biospecimen Collection, Erdafitinib - Castration-Resistant Prostate Carcinoma, Castration-Resistant Prostate Carcinoma Refractory to Second-Generation Androgen Receptor Axis-Targeted Agents | Phase 2 | Terminated | M.D. Anderson Cancer Center | 11 | 2021-07-15 | 2026-02-06 |
| 68Ga-PSMA-11 PET/CT for the Diagnosis of Bone Metastases in Patients With Prostate Cancer and Biochemical Progression During Androgen Deprivation Therapy Computed Tomography, Gallium Ga 68 Gozetotide, Positron Emission Tomography - Biochemically Recurrent Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone | Phase 2 | Terminated | Jonsson Comprehensive Cancer Center | 22 | 2021-06-16 | 2022-10-21 |
| Impact of DNA Repair Pathway Alterations on Sensitivity to Radium-223 in Bone Metastatic Castration-resistant Prostate Cancer Biospecimen Collection, Questionnaire Administration, Radium Ra 223 Dichloride - Castration-Resistant Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone | Recruiting | University of Washington | 48 | 2021-04-16 | 2026-10-22 | |
| Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial Cryosurgery, Quality-of-Life Assessment, Stereotactic Body Radiation Therapy - Castration-Resistant Prostate Carcinoma, Metastatic Colorectal Carcinoma | Not applicable | Recruiting | M.D. Anderson Cancer Center | 40 | 2021-03-16 | 2026-04-15 |
| Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive to Hormonal Therapy Avelumab, Biospecimen Collection, Bone Scan - Metastatic Castration-Resistant Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone | Phase 1 / Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 90 | 2020-10-14 | 2026-10-07 |
| Testing the Addition of Radium Therapy (Radium-223 Dichloride) to the Usual Chemotherapy Treatment (Paclitaxel) for Advanced Breast Cancer That Has Spread to the Bones Biospecimen Collection, Bone Scan, Computed Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic HER2-Negative Breast Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 70 | 2020-08-04 | 2026-09-18 |
| Testing the Addition of a New Anti-cancer Drug, Radium-223 Dichloride, to the Usual Treatment (Cabozantinib) for Advanced Renal Cell Cancer That Has Spread to the Bone, RadiCaL Study Biospecimen Collection, Bone Scan, Cabozantinib S-malate - Advanced Renal Cell Carcinoma, Chromophobe Renal Cell Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 98 | 2020-07-29 | 2026-09-28 |
| Antiandrogen Therapy, Abiraterone Acetate, and Prednisone With or Without Neutron Radiation Therapy in Treating Patients With Prostate Cancer Antiandrogen Therapy, Abiraterone Acetate, Prednisone - Castration-Sensitive Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone | Phase 2 | Terminated | University of Washington | 10 | 2020-06-29 | 2023-10-26 |
| Salvage Oligometastasectomy and Radiation Therapy in Recurrent Prostate Cancer Hypofractionated Radiation Therapy, Intensity-Modulated Radiation Therapy, Metastasectomy - Recurrent Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone | Phase 2 | Completed | University of Utah | 20 | 2019-09-09 | 2026-07-22 |
| Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study Biospecimen Collection, Bone Scan, Cabozantinib - Clear Cell Renal Cell Carcinoma, Metastatic Malignant Neoplasm in the Bone | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 1175 | 2019-06-07 | 2026-10-26 |
| Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma Quality-of-Life Assessment, Questionnaire Administration, Radiation Therapy - Bone Pain, Metastatic Malignant Neoplasm in the Bone | Not applicable | Recruiting | University of Southern California | 100 | 2019-03-11 | 2026-06-05 |
| Radiation Therapy, Palbociclib, and Hormone Therapy in Treating Breast Cancer Patients With Bone Metastasis Anastrozole, Exemestane, Fulvestrant - Anatomic Stage IV Breast Cancer AJCC v8, Estrogen Receptor Positive | Phase 2 | Completed | Emory University | 36 | 2019-02-08 | 2025-02-17 |
| Nivolumab and Ipilimumab and Stereotactic Body Radiation Therapy in Treating Patients With Salivary Gland Cancers Nivolumab, Ipilimumab, Stereotactic Body Radiation Therapy - Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Neoplasm in the Lung | Phase 1 / Phase 2 | Completed | University of Washington | 20 | 2019-01-15 | 2023-12-29 |
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Prostatic Neoplasms (18) · Neoplasm Metastasis (5) · Lymphatic Metastasis (4) · Breast Neoplasms (3) · Carcinoma, Renal Cell (3) · Bone Neoplasms (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Transitional Cell (1) · Colorectal Neoplasms (1) · Lung Neoplasms (1) · Melanoma (1) · Multiple Myeloma (1) · Neoplasms (1) · Pain (1) · Salivary Gland Neoplasms (1)
Neoplasms (31) · Neoplasms by Site (25) · Male Urogenital Diseases (20) · Urogenital Diseases (20) · Urogenital Neoplasms (20) · Genital Diseases (18) · Genital Diseases, Male (18) · Genital Neoplasms, Male (18) · Prostatic Diseases (18) · Pathological Conditions, Signs and Symptoms (10) · Neoplastic Processes (9) · Pathologic Processes (9) · Neoplasms by Histologic Type (5) · Skin Diseases (5) · Skin and Connective Tissue Diseases (5)
Magnetic Resonance Spectroscopy (10) · Specimen Handling (7) · Radiation (6) · Radiosurgery (6) · radium Ra 223 dichloride (5) · Radiotherapy (4) · CTLA-4 Antigen (2) · Fluorodeoxyglucose F18 (2) · Glutamate Carboxypeptidase II (2) · Immunoglobulin G (2) · Ipilimumab (2) · Nivolumab (2) · Pentetic Acid (2) · Photons (2) · Surgical Procedures, Operative (2)
National Cancer Institute (NCI) (8) · M.D. Anderson Cancer Center (6) · University of Washington (5) · City of Hope Medical Center (2) · NRG Oncology (2) · Emory University (1) · Jonsson Comprehensive Cancer Center (1) · Mayo Clinic (1) · OHSU Knight Cancer Institute (1) · Roswell Park Cancer Institute (1) · Stanford University (1) · University of California, San Francisco (1) · University of Southern California (1) · University of Utah (1) · University of Wisconsin, Madison (1)
United States (32) · Canada (3) · Puerto Rico (2) · Saudi Arabia (1) · South Korea (1)
Zin W Myint (2) · Adam Garsa, MD (1) · Alana M Munger (1) · Alejandro Sanchez (1) · Alexandra Sokolova, M.D. (1) · Andrei Iagaru (1) · Behrang Amini (1) · Cristina Rodriguez (1) · Donald W Northfelt (1) · Doris R Brown (1) · Douglas G McNeel, MD PhD (1) · Erin F Gillespie (1) · Evan Y. Yu, MD (1) · Evan Yu (1) · Gurkamal Chatta, MD (1)
PMID 29876010, PMID 30700328, PMID 33604999, PMID 34663638, PMID 35277461, PMID 35304832, PMID 35383907, PMID 35428207, PMID 35602670, PMID 36669140, PMID 39420060, PMID 40377420, PMID 41378786, PMID 41825136, PMID 42208702, PMID 42507969
P50CA097186 (3), P30CA033572 (2), U10CA180821 (2), UM1CA186712 (2), 2015 (1), P30CA012197 (1), P30CA014089 (1), P30CA015704 (1), P30CA124435 (1), P30CA138292 (1), U01CA080098 (1), U10CA098543 (1), U10CA180820 (1), U10CA180868 (1), U10CA180886 (1)