8 completed, 5 terminated, 4 active not recruiting. 17 Phase 2, 4 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 17 | Completed 8, Terminated 5, Active not recruiting 4 |
| Phase 1 | 4 | Completed 2, Active not recruiting 1, Terminated 1 |
| Phase 3 | 1 | Completed 1 |
Follow Metastatic Malignant Neoplasm in the Bone: new trials by email Literature Review of Metastatic Malignant Neoplasm in the Bone trials Research Report on Metastatic Malignant Neoplasm in the Bone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Ra-223 in PSMA PET Optimally Selected Patients Radium-223, PSMA Positron Emission Tomography (PET) Scan, Technetium Tc 99M Medronate - Castration-Resistant Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone | Phase 2 | Active not recruiting | University of California, San Francisco | 2 | 2024-08-30 | 2026-01-14 |
| Treatment of Cancer-Related Bone Pain by Using Bone-Targeted Radiation-Based Therapy (Sn-117m-DTPA) in Patients With Prostate Cancer That Has Spread to Bones Questionnaire Administration, Tin Sn 117m Pentetate - Castration-Resistant Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone | Phase 2 | Terminated | National Cancer Institute (NCI) | 1 | 2021-12-18 | 2025-10-03 |
| Erdafitinib for the Treatment of Patients With Castration-Resistant Prostate Cancer Biopsy, Biospecimen Collection, Erdafitinib - Castration-Resistant Prostate Carcinoma, Castration-Resistant Prostate Carcinoma Refractory to Second-Generation Androgen Receptor Axis-Targeted Agents | Phase 2 | Terminated | M.D. Anderson Cancer Center | 11 | 2021-07-15 | 2026-02-06 |
| 68Ga-PSMA-11 PET/CT for the Diagnosis of Bone Metastases in Patients With Prostate Cancer and Biochemical Progression During Androgen Deprivation Therapy Computed Tomography, Gallium Ga 68 Gozetotide, Positron Emission Tomography - Biochemically Recurrent Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone | Phase 2 | Terminated | Jonsson Comprehensive Cancer Center | 22 | 2021-06-16 | 2022-10-21 |
| Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive to Hormonal Therapy Avelumab, Biospecimen Collection, Bone Scan - Metastatic Castration-Resistant Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone | Phase 1 / Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 90 | 2020-10-14 | 2026-10-07 |
| Testing the Addition of Radium Therapy (Radium-223 Dichloride) to the Usual Chemotherapy Treatment (Paclitaxel) for Advanced Breast Cancer That Has Spread to the Bones Biospecimen Collection, Bone Scan, Computed Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic HER2-Negative Breast Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 70 | 2020-08-04 | 2026-09-18 |
| Testing the Addition of a New Anti-cancer Drug, Radium-223 Dichloride, to the Usual Treatment (Cabozantinib) for Advanced Renal Cell Cancer That Has Spread to the Bone, RadiCaL Study Biospecimen Collection, Bone Scan, Cabozantinib S-malate - Advanced Renal Cell Carcinoma, Chromophobe Renal Cell Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 98 | 2020-07-29 | 2026-09-28 |
| Antiandrogen Therapy, Abiraterone Acetate, and Prednisone With or Without Neutron Radiation Therapy in Treating Patients With Prostate Cancer Antiandrogen Therapy, Abiraterone Acetate, Prednisone - Castration-Sensitive Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone | Phase 2 | Terminated | University of Washington | 10 | 2020-06-29 | 2023-10-26 |
| Salvage Oligometastasectomy and Radiation Therapy in Recurrent Prostate Cancer Hypofractionated Radiation Therapy, Intensity-Modulated Radiation Therapy, Metastasectomy - Recurrent Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone | Phase 2 | Completed | University of Utah | 20 | 2019-09-09 | 2026-07-22 |
| Radiation Therapy, Palbociclib, and Hormone Therapy in Treating Breast Cancer Patients With Bone Metastasis Anastrozole, Exemestane, Fulvestrant - Anatomic Stage IV Breast Cancer AJCC v8, Estrogen Receptor Positive | Phase 2 | Completed | Emory University | 36 | 2019-02-08 | 2025-02-17 |
| Nivolumab and Ipilimumab and Stereotactic Body Radiation Therapy in Treating Patients With Salivary Gland Cancers Nivolumab, Ipilimumab, Stereotactic Body Radiation Therapy - Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Neoplasm in the Lung | Phase 1 / Phase 2 | Completed | University of Washington | 20 | 2019-01-15 | 2023-12-29 |
| Durvalumab and Tremelimumab in Treating Chemotherapy Naive Patients With Metastatic Castration-Resistant Prostate Cancer Durvalumab, Tremelimumab - Castration-Resistant Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone | Phase 2 | Completed | M.D. Anderson Cancer Center | 31 | 2017-07-14 | 2024-10-15 |
| Sirolimus, Docetaxel, and Carboplatin in Treating Patients With Metastatic Castration-Resistant Prostate Cancer Carboplatin, Docetaxel, Laboratory Biomarker Analysis - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 1 / Phase 2 | Terminated | University of Washington | 28 | 2016-02-29 | 2021-10-01 |
| Vaccine Therapy and Pembrolizumab in Treating Patients With Hormone-Resistant, Metastatic Prostate Cancer Pembrolizumab, pTVG-HP Plasmid DNA Vaccine - Hormone-Resistant Prostate Cancer, Metastatic Malignant Neoplasm in the Bone | Phase 1 / Phase 2 | Completed | University of Wisconsin, Madison | 66 | 2015-07-01 | 2023-08-01 |
| Testing Whether Treating Breast Cancer Metastases With Surgery or High-Dose Radiation Improves Survival Stereotactic Body Radiotherapy, Surgery - Anatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8, Metastatic Breast Carcinoma | Phase 2 / Phase 3 | Completed | NRG Oncology | 129 | 2014-12-24 | 2026-07-10 |
| Genetic and Molecular Mechanisms in Assessing Response in Patients With Prostate Cancer Receiving Enzalutamide Therapy Enzalutamide - Castration-Resistant Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone | Phase 2 | Completed | OHSU Knight Cancer Institute | 36 | 2014-02-05 | 2024-09-19 |
| Fluorine F 18 Sodium Fluoride Positron Emission Tomography in Evaluating Response to Dasatinib in Patients With Prostate Cancer and Bone Metastases Fluorine F 18 Sodium Fluoride - Hormone-Resistant Prostate Cancer, Metastatic Malignant Neoplasm in the Bone | Phase 2 | Completed | National Cancer Institute (NCI) | 18 | 2009-09-01 | 2015-07-16 |
Prostatic Neoplasms (12) · Lymphatic Metastasis (3) · Breast Neoplasms (2) · Carcinoma, Renal Cell (1) · Salivary Gland Neoplasms (1)
Neoplasms (16) · Neoplasms by Site (16) · Male Urogenital Diseases (13) · Urogenital Diseases (13) · Urogenital Neoplasms (13) · Genital Diseases (12) · Genital Diseases, Male (12) · Genital Neoplasms, Male (12) · Prostatic Diseases (12) · Neoplasm Metastasis (3) · Neoplastic Processes (3) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Breast Diseases (2) · Skin Diseases (2)
Magnetic Resonance Spectroscopy (4) · radium Ra 223 dichloride (4) · Radiosurgery (3) · Specimen Handling (3) · Immunoglobulin G (2) · Radiation (2) · Radiotherapy (2) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · 68Ga-DKFZ-PSMA-11 (1) · Abiraterone Acetate (1) · Anastrozole (1) · Androgen Antagonists (1) · Biopsy (1) · CTLA-4 Antigen (1) · Carboplatin (1)
National Cancer Institute (NCI) (5) · University of Washington (3) · M.D. Anderson Cancer Center (2) · Emory University (1) · Jonsson Comprehensive Cancer Center (1) · NRG Oncology (1) · OHSU Knight Cancer Institute (1) · University of California, San Francisco (1) · University of Utah (1) · University of Wisconsin, Madison (1)
United States (17) · Canada (1) · Saudi Arabia (1) · South Korea (1)
Alejandro Sanchez (1) · Alexandra Sokolova, M.D. (1) · Cristina Rodriguez (1) · Douglas G McNeel, MD PhD (1) · Evan Yu (1) · Jeremie Calais, MD (1) · Jing Zeng (1) · Mylin Torres, MD (1) · Paul Corn (1) · Rana R McKay (1) · Robert Montgomery (1) · Russell K Pachynski (1) · Scott M Glaser (1) · Steven J Chmura (1) · Sumit K Subudhi (1)
PMID 29876010, PMID 30700328, PMID 33604999, PMID 34663638, PMID 35277461, PMID 35428207, PMID 35602670, PMID 39420060, PMID 41378786, PMID 42507969
P50CA097186 (2), P30CA015704 (1), P30CA138292 (1), U01CA080098 (1), U10CA180820 (1), U10CA180821 (1), U10CA180868 (1), UM1CA186644 (1), UM1CA186689 (1), UM1CA186704 (1), UM1CA186712 (1), UM1CA186716 (1)