30 completed, 6 unknown, 5 terminated, 4 recruiting. 46 Phase 2, 9 Phase 3, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 46 | Completed 30, Unknown 6, Terminated 5, Recruiting 4, Withdrawn 1 |
| Phase 3 | 9 | Completed 5, Unknown 3, Terminated 1 |
| Phase 1 | 4 | Completed 3, Withdrawn 1 |
Follow Leishmaniasis, Cutaneous: new trials by email Literature Review of Leishmaniasis, Cutaneous trials Research Report on Leishmaniasis, Cutaneous
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intralesional Injection of Metronidazole for the Management of Cutaneous Leishmaniasis Metronidazole - Cutaneous Leishmaniasis | Phase 2 | Recruiting | Hayder Adnan Fawzi | 40 | 2025-02-10 | 2025-02-14 |
| Intralesional Injection of Levofloxacin for the Management of Cutaneous Leishmaniasis Levofloxacin 0.5% - Cutaneous Leishmaniasis | Phase 2 | Recruiting | Hayder Adnan Fawzi | 40 | 2025-02-09 | 2025-09-30 |
| Ciprofloxacin Intralesional Injection for the Treatment of Cutaneous Leishmaniasis Compared to Sodium Stibogluconate Ciprofloxacin (BAYO9867), sodium stibogluconate (Pentostam) - Cutaneous Leishmaniasis | Phase 2 | Recruiting | Al-Mustafa University College | 80 | 2025-02-07 | 2025-09-30 |
| Treatment of Bolivian L Braziliensis Mucosal Leishmaniasis With Inhaled Pentamidine Plus Oral Miltefosine Miltefosine Oral Capsule - Mucosal Leishmaniasis | Phase 2 | Recruiting | Fundacion Nacional de Dermatologia | 30 | 2025-02-04 | 2025-02-26 |
| Tofacitinib Associated With Meglumine Antimoniate in Cutaneous Leishmaniasis Oral tofacitinib, Parenteral meglumine antimoniate - Cutaneous Leishmaniasis, American | Phase 2 / Phase 3 | Unknown | Hospital Universitário Professor Edgard Santos | 22 | 2023-10-01 | 2023-08-25 |
| Pilot Study: Oral Treatment of American Tegumentary Leishmaniasis (Cutaneous and Mucosal Forms) in the Elderly Miltefosine 50mg, Pentoxifylline 400mg, Liposomal Amphotericin B - Leishmaniasis; Brazilian, Leishmaniasis, Mucocutaneous | Phase 2 / Phase 3 | Unknown | University of Brasilia | 100 | 2022-06-22 | 2023-09-15 |
| Phase 2 Trial to Evaluate 18-Methoxycoronaridine Efficacy, Safety and Tolerability in Cutaneous Leishmaniasis Patients 18-Methoxycoronaridine, Glucantime - Leishmaniasis; American, Cutaneous, Drug Side Effect | Phase 2 | Unknown | Infan Industria Quimica Farmaceutica Nacional | 52 | 2021-05-01 | 2020-03-19 |
| Evaluation of the Safety and Clinical Activity of Curaleish in the Topical Treatment of Cutaneous Leishmaniasis. Experimental topical (Curaleish Topical) - Leishmaniasis, Cutaneous | Phase 1 / Phase 2 | Withdrawn | Universidad de Antioquia | 2021-01-01 | 2022-06-03 | |
| A Study to Assess the Safety, Efficacy and Immunogenicity of Leishmania Vaccine ChAd63-KH in PKDL ChAd63-KH, Placebo - Leishmaniasis, Cutaneous | Phase 2 | Completed | University of York | 86 | 2020-04-06 | 2023-05-26 |
| Treatment of Cutaneous Leishmaniasis With Liposomal Amphotericin B in the Elderly Liposomal amphotericin B (AmBisome®) - Cutaneous Leishmaniasis, American | Phase 1 / Phase 2 | Completed | Hospital Universitário Professor Edgard Santos | 28 | 2019-03-01 | 2024-06-07 |
| Oral Miltefosine Plus Topical Paromomycin In American Cutaneous Leishmaniasis Miltefosine and Paromomycin, miltefosine, paromomycin - Cutaneous Leishmaniasis, American | Phase 2 / Phase 3 | Completed | Fundacion Nacional de Dermatologia | 120 | 2019-02-01 | 2021-02-02 |
| Topical Sm29 in Combination With Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis. Sm29 Protein, Schistosoma Mansoni, Pentavalent antimony (Sbv) - Cutaneous Leishmaniasis, American | Phase 1 / Phase 2 | Completed | Hospital Universitário Professor Edgard Santos | 20 | 2019-01-17 | 2023-08-21 |
| Topical Paromomycin for Cutaneous Leishmaniasis in Bolivia Paromomycin Sulfate, Pentamidine Isethionate, Placebo - Leishmaniasis, Cutaneous, Leishmania Braziliensis Complex | Phase 2 / Phase 3 | Completed | Fundacion Nacional de Dermatologia | 80 | 2017-04-15 | 2021-02-02 |
| Thermotherapy + a Short Course of Miltefosine for the Treatment of Uncomplicated Cutaneous Leishmaniasis in the New World¨ Miltefosine - Cutaneous Leishmaniasis | Phase 2 | Completed | Drugs for Neglected Diseases | 130 | 2016-12-01 | 2019-09-12 |
| A Study of a New Leishmania Vaccine Candidate ChAd63-KH ChAd63-KH - Leishmaniasis, Cutaneous | Phase 2 | Completed | University of York | 24 | 2016-11-01 | 2020-01-28 |
| Miltefosine Plus IL Pentamidine for Bolivian CL miltefosine plus intralesional pentamidine - Leishmaniasis, Cutaneous | Phase 2 | Completed | Jonathan Berman | 50 | 2016-01-31 | 2018-02-27 |
| Fourth-generation Immucillin Derivative DI4G Associated Therapy in Cutaneous Leishmaniasis Immucillin DI4G, Meglumine antimoniate - Leishmaniasis, Leishmaniasis, Cutaneous | Phase 2 | Completed | Hospital Universitário Professor Edgard Santos | 50 | 2014-12-01 | 2017-09-26 |
| Topical 3% Amphotericin B Cream for the Treatment of Cutaneous Leishmaniasis in Colombia Topical Amphotericin B at 3% - Cutaneous Leishmaniasis | Phase 1 / Phase 2 | Completed | Drugs for Neglected Diseases | 80 | 2014-02-01 | 2016-07-26 |
| Efficacy and Safety of Pentamidine (7mg/kg) for Patients With Cutaneous Leishmaniasis Caused by L. Guyanensis Single dose of Pentamidine, Two doses of Pentamidine, Three doses of Pentamidine - Cutaneous Leishmaniases | Phase 2 | Completed | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado | 159 | 2014-01-01 | 2019-02-15 |
| Safety, Efficacy, and PK of Topical Paromomycin/Gentamicin Cream for Treatment of Cutaneous Leishmaniasis WR 279,396 - Leishmaniasis, Cutaneous | Phase 2 | Terminated | U.S. Army Medical Research and Development Command | 1 | 2013-09-01 | 2019-11-22 |
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Leishmaniasis (19) · Leishmaniasis, Mucocutaneous (12) · Drug-Related Side Effects and Adverse Reactions (1) · Hypersensitivity, Delayed (1)
Euglenozoa Infections (46) · Infections (46) · Parasitic Diseases (46) · Protozoan Infections (46) · Skin Diseases (46) · Skin Diseases, Infectious (46) · Skin Diseases, Parasitic (46) · Skin and Connective Tissue Diseases (46) · Vector Borne Diseases (46) · Leishmaniasis (27) · Chemically-Induced Disorders (1) · Hypersensitivity (1) · Immune System Diseases (1)
miltefosine (12) · Meglumine Antimoniate (9) · Paromomycin (6) · Antimony Sodium Gluconate (3) · Pentoxifylline (3) · Antimony (2) · Cryotherapy (2) · Pentamidine (2) · liposomal amphotericin B (2) · 18-methoxycoronaridine (1) · Azithromycin (1) · Ciprofloxacin (1) · Contraceptives, Oral (1) · Imiquimod (1) · Metronidazole (1)
U.S. Army Medical Research and Development Command (8) · Hospital Universitário Professor Edgard Santos (6) · Fundacion Nacional de Dermatologia (4) · Access to Advanced Health Institute (AAHI) (2) · Drugs for Neglected Diseases (2) · Foundation Fader (2) · Hayder Adnan Fawzi (2) · Oswaldo Cruz Foundation (2) · University of York (2) · AB Foundation (1) · Al-Mustafa University College (1) · Ana Rabello (1) · Assistance Publique - Hôpitaux de Paris (1) · Brasilia University Hospital (1) · Centro Internacional de Entrenamiento e Investigaciones Médicas (1)
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Afif Ben Salah, M.D., Ph.D. (2) · Armando O. Schubach, MD, PhD (2) · Ivan Dario Velez, Prof (2) · Paulo RL Machado, MD, PhD (2) · Afif Ben Salah,, MD, PhD (1) · Ahmed Musa, MBBS (1) · Alejandro Llanos-Cuentas, M.D. (1) · Alejandro Llanos-Cuentas, MD, PhD (1) · Ana Rabello, MD PhD (1) · Anette Talhari, Doctor (1) · Claes D Enk, MD, PhD (1) · Donald M Brandon, M.D. (1)
PMID 23877689, PMID 19415122, PMID 20231896, PMID 20438389, PMID 21200420, PMID 23390069, PMID 27927991, PMID 28379954, PMID 28558061, PMID 30044792, PMID 30260376, PMID 30379814, PMID 33781913, PMID 35255096, PMID 36395328, PMID 37252616, PMID 39147194, PMID 39253357
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