80 completed, 22 recruiting, 17 unknown, 9 active not recruiting. 21 Phase 2, 20 Phase 3, 16 Not applicable, 15 Phase 4, 5 Phase 1.
Follow Gonadal Dysgenesis: new trials by email Literature Review of Gonadal Dysgenesis trials Research Report on Gonadal Dysgenesis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SEMAFORCRANIO : Multicenter, Double-blind, Parallel, Randomized Controlled Trial of the Efficacy of Semaglutide in Hypothalamic Obesity Secondary to Craniopharyngioma in Children Aged 12 to 17 Years Semaglutide (Wegovy) weekly injection, Placebo weekly Injection - Craniopharyngioma, Child | Phase 3 | Not yet recruiting | University Hospital, Angers | 50 | 2026-11-01 | 2026-09-29 |
| Sexual Quality of Life in Female Patients With Lipodystrophy Syndromes or Turner's Syndrome: a Case-control Study Lipodystrophy Congenital Generalized, Lipodystrophy, Familial Partial | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 1416 | 2026-10-01 | 2026-09-02 | |
| Hematological Profile in Children With Numerical Chromosomal Disorders Down Syndrome, Turner Syndrome | Not yet recruiting | Assiut University | 158 | 2026-09-02 | 2026-09-10 | |
| Pre-pubertal Low Dose Transdermal Estradiol in Turner Syndrome Estradiol transdermal patch 0.025mg/24 hours- 1/8th fractionated patch - Turner Syndrome, Primary Ovarian Insufficiency | Phase 2 | Not yet recruiting | Children's National Research Institute | 15 | 2026-09-01 | 2026-08-25 |
| The Efficacy and Safety of Inpegsomatropin Injection in Children With Turner Syndrome (TS) and Short Stature Inpegsomatropin-Injection, Givopegsomatropin Solution Injection - Turner Syndrome | Phase 3 | Recruiting | Xiamen Amoytop Biotech Co., Ltd. | 84 | 2026-07-05 | 2026-07-22 |
| A Multiple Baseline Feasibility Trial of Social Management Training for People With Sex Chromosome Aneuploidies Social Management Training - Sex Chromosome Disorders | Phase 1 | Recruiting | University of Oslo | 30 | 2026-06-01 | 2026-07-22 |
| A Study Comparing Different Treatment Approaches for the Initiation of Puberty in Girls With Turner Syndrome Using a TRIFECTA-DARED Approach for Rare Diseases Oral estradiol valerate, Transdermal 17β estradiol - Turner Syndrome | Phase 2 | Not yet recruiting | Universiti Kebangsaan Malaysia Medical Centre | 24 | 2026-02-15 | 2026-02-02 |
| Trial Investigating the Efficacy and Safety of Weekly Lonapegsomatropin Compared to Daily Somatropin in Children and Adolescents With Short Stature or Growth Failure Due to Growth Hormone Sufficient Disorders Lonapegsomatropin [SKYTROFA®], Somatropin Pen Injector - Turner Syndrome, Short Stature Homeobox Gene Mutation | Phase 3 | Recruiting | Ascendis Pharma A/S | 186 | 2025-12-12 | 2026-09-30 |
| Parental Project Amongst 93 Patients With Turner Syndrome Turner Syndrome | Recruiting | University Hospital, Strasbourg, France | 93 | 2025-11-18 | 2026-01-15 | |
| A Long-Term Study of Bivamelagon in Participants With Hypothalamic Obesity (HO) Bivamelagon - Hypothalamic Obesity | Phase 2 | Enrolling by invitation | Rhythm Pharmaceuticals, Inc. | 25 | 2025-11-10 | 2026-02-10 |
| A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756) Setmelanotide, Placebo - Hypothalamic Obesity, Multiple Pituitary Hormone Deficiency Genetic Form | Phase 3 | Recruiting | Rhythm Pharmaceuticals, Inc. | 39 | 2025-09-23 | 2026-02-12 |
| Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome Micronized progesterone 200 MG, Micronized Progesterone 100 MG - Turner Syndrome, Primary Ovarian Insufficiency (Poi) | Phase 4 | Recruiting | Children's Mercy Hospital Kansas City | 40 | 2025-07-31 | 2026-08-25 |
| Tirzepatide in PWS, HO and GNSO Tirzepatide - Prader-Willi Syndrome, Hypothalamic Obesity | Phase 4 | Recruiting | Grace Kim | 36 | 2025-05-01 | 2025-09-16 |
| Implications of Maternal 45,X Mosaicism as a Secondary Genomic Finding Following Cell-Free DNA Sequencing During Pregnancy: A Deep Phenotype Study Cardiovascular Phenotype, Metabolic Phenotype | Withdrawn | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 2025-04-01 | 2025-04-02 | ||
| Efficacy and Safety of Phentermine/Topiramate in Youth With Hypothalamic Obesity Phentermine / Topiramate Extended Release Oral Capsule [Qsymia], Placebo - Hypothalamic Obesity, Hypothalamic Tumor | Phase 2 | Active not recruiting | Seattle Children's Hospital | 24 | 2025-03-01 | 2026-10-16 |
| Genetic and Epigenetic Background of Inner Ear Dysfunction in Turner Syndrome Sensorineural Hearing Loss, Turner Syndrome | Recruiting | Gødstrup Hospital | 150 | 2025-02-01 | 2026-09-11 | |
| Characterization of Hepatopathy in Turner Syndrome: Analysis of Determinants Turner Syndrome | Recruiting | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 120 | 2025-01-07 | 2025-01-27 | |
| Growing up With the Young Endocrine Support System (YESS!) YESS! game, Snake '97, Transition-toolkit - Congenital Adrenal Hyperplasia, Hypogonadotropic Hypogonadism | Not applicable | Not yet recruiting | dr. Laura C. G. de Graaff-Herder | 160 | 2024-12-01 | 2023-09-07 |
| Open-Label Extension Study of Setmelanotide Setmelanotide - Obesity Associated With Defects in Leptin-melanocortin Pathway | Phase 3 | Completed | Rhythm Pharmaceuticals, Inc. | 28 | 2024-10-21 | 2026-07-15 |
| Clinical and Genetic Aspects in Fetuses and Children With Sex Chromosome Disorders Sex Chromosome Disorders | Enrolling by invitation | University of Aarhus | 300 | 2024-09-01 | 2026-01-14 |
Showing 20 of 149. Sign in to see all of them.
Turner Syndrome (124) · Sexual Infantilism (23) · Down Syndrome (14) · Klinefelter Syndrome (14) · Trisomy 18 Syndrome (13) · Dwarfism, Pituitary (12) · Genetic Diseases, Inborn (12) · Trisomy 13 Syndrome (12) · Dwarfism (10) · Primary Ovarian Insufficiency (10) · Craniopharyngioma (8) · Hypogonadism (7) · Sex Chromosome Aberrations (7) · Noonan Syndrome (6)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (149) · Female Urogenital Diseases (149) · Female Urogenital Diseases and Pregnancy Complications (149) · Gonadal Disorders (149) · Male Urogenital Diseases (149) · Urogenital Abnormalities (149) · Urogenital Diseases (149) · Congenital Abnormalities (148) · Endocrine System Diseases (148) · Disorders of Sex Development (146) · Chromosome Disorders (125) · Cardiovascular Abnormalities (124) · Heart Diseases (123) · Sex Chromosome Disorders of Sex Development (123)
Human Growth Hormone (24) · Growth Hormone (10) · Estradiol (8) · Exenatide (5) · setmelanotide (4) · Blood Specimen Collection (3) · Estrogens (3) · Oxandrolone (2) · estradiol, estriol drug combination (2) · lonapegsomatropin (2) · somapacitan (2) · Androgens (1) · DNA, Ribosomal (1) · Diagnostic Imaging (1) · Diazoxide (1)
University of Aarhus (13) · Novo Nordisk A/S (12) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (7) · Rhythm Pharmaceuticals, Inc. (7) · Natera, Inc. (6) · Assistance Publique - Hôpitaux de Paris (5) · Merck KGaA, Darmstadt, Germany (4) · Eli Lilly and Company (3) · Ferring Pharmaceuticals (3) · Seattle Children's Hospital (3) · University Hospital, Strasbourg, France (3) · University of Colorado, Denver (3) · dr. Laura C. G. de Graaff-Herder (3) · Aarhus University Hospital (2) · Changchun GeneScience Pharmaceutical Co., Ltd. (2)
United States (65) · France (26) · Denmark (19) · Spain (13) · United Kingdom (13) · Netherlands (11) · Germany (10) · Italy (10) · South Korea (9) · Canada (8) · China (6) · Belgium (5) · Sweden (5) · Czechia (4) · Ireland (4)
David Meeker, MD (6) · Barbara Lippe, M.D. (2) · Christian Trolle, MD (2) · Claus H Gravholt, MD (2) · Claus H Gravholt, Professor (2) · Imen Mehri Turki (2) · Nelly Mauras, MD (2) · Peer Dar, MD (2) · Shana E McCormack, MD (2) · Veronica Gomez-Lobo, M.D. (2)
PMID 36978128, PMID 10417280, PMID 10518081, PMID 10599727, PMID 10599729, PMID 11531930, PMID 12466334, PMID 12629094, PMID 12820840, PMID 15784709, PMID 15900109, PMID 16757526, PMID 16814942, PMID 17535868, PMID 17875973, PMID 19699898, PMID 20375405, PMID 20733274, PMID 21294891, PMID 21310373, PMID 21398400, PMID 21406078, PMID 21449786, PMID 21519036, PMID 21619701, PMID 21880799, PMID 21982653, PMID 22005709, PMID 22104675, PMID 22281937, PMID 22464072, PMID 22508317, PMID 22617594, PMID 22742782, PMID 22788856, PMID 23215555, PMID 23444191, PMID 23567489, PMID 23613152, PMID 23658497, PMID 23678038, PMID 23712453, PMID 23737664, PMID 23936059, PMID 24135152, PMID 24388429, PMID 24571752, PMID 24762109, PMID 24785862, PMID 24923356
UL1TR001082 (2), 2004 (1), 2008 (1), 2009 (1), 268201000048C-5-0-1 (1), K01MH083045 (1), N01HV681997 (1), R44HD062114 (1), UL1TR000077 (1)