16 completed, 2 not yet recruiting, 1 recruiting, 1 terminated. 11 Phase 1, 5 Not applicable, 3 Phase 3, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 11 | Completed 9, Recruiting 1, Terminated 1 |
| Not applicable | 5 | Completed 4, Unknown 1 |
| Phase 3 | 3 | Not yet recruiting 2, Completed 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Hookworm Infection: new trials by email Literature Review of Hookworm Infection trials Research Report on Hookworm Infection
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections emodepside (BAY 44-4400), Mebendazole 100 MG, similar placebo to mebendazole - Trichuris Trichiura; Infection, Hookworm Infection | Phase 3 | Not yet recruiting | Swiss Tropical & Public Health Institute | 315 | 2026-11-06 | 2026-08-14 |
| Combination Therapies for Trichuris Trichiura Infection in Schoolchildren in Honduras Placebo, Albendazole 400 mg, Albendazole Plus Ivermectin - Trichuriasis, Strongyloidiasis | Phase 3 | Not yet recruiting | Mundo Sano Foundation | 368 | 2026-11-01 | 2026-06-23 |
| Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections emodepside (BAY 44-4400), matching placebo of emodepside, Mebendazole - Trichuris Trichiura; Infection, Hookworm Infection | Phase 3 | Completed | Swiss Tropical & Public Health Institute | 315 | 2025-11-25 | 2026-10-08 |
| Efficacy and Safety of Oxantel Pamoate in Children Infected With Trichuris Trichiura Oxantel Pamoate, Mebendazole - Trichuris Trichiura; Infection, Hookworm Infection | Phase 2 | Completed | Jennifer Keiser | 163 | 2025-04-16 | 2025-06-08 |
| Evaluating Impact of Improved Floors on Health Sealed washable floor plus behaviour change, Behaviour change intervention, Routine deworming - Diarrhoeal Disease, Hookworm Infection | Not applicable | Completed | London School of Hygiene and Tropical Medicine | 2200 | 2023-04-12 | 2025-01-30 |
| Na-GST-1/Alhydrogel With or Without CpG 10104 in Gabonese Adults Na-GST-1, CPG 10104 - Hookworm Infection, Hookworm Disease | Phase 1 | Completed | Baylor College of Medicine | 24 | 2018-02-01 | 2021-01-13 |
| Triple Combinations Against Hookworm Infections in Lao Albendazole, Pyrantel Pamoate, Oxantel Pamoate - Hookworm Infection | Phase 4 | Completed | Swiss Tropical & Public Health Institute | 420 | 2017-09-27 | 2018-05-08 |
| Study of Co-administered Na-APR-1 (M74) and Na-GST-1 in Gabonese Children Na-GST-1/Alhydrogel, Na-APR-1 (M74)/Alhydrogel, Hepatitis B Vaccine - Hookworm Disease, Hookworm Infection | Phase 1 | Completed | Baylor College of Medicine | 60 | 2017-01-01 | 2025-01-13 |
| Study of Na-APR-1 (M74)/Alhydrogel® Co-administered With Na-GST-1/Alhydrogel in Brazilian Adults Na-GST-1/Alhydrogel plus GLA-AF, Na-APR-1 (M74)/Alhydrogel, Na-APR-1 (M74)/Alhydrogel plus GLA-AF - Hookworm Infection, Hookworm Disease | Phase 1 | Completed | Baylor College of Medicine | 60 | 2016-01-01 | 2019-12-03 |
| Experimental Infection of Hookworm-naïve Adults With Dermally-applied Infectious Necator Americanus Hookworm Larvae Necator americanus Hookworm Larvae - Hookworm Infection | Phase 1 | Recruiting | Baylor College of Medicine | 35 | 2015-01-01 | 2026-05-18 |
| Safety and Immunogenicity of Co-Administered Hookworm Vaccine Candidates Na-GST-1 and Na-APR-1 in Gabonese Adults Na-APR-1 (M74)/Alhydrogel®, Na-GST-1/Alhydrogel®, Hepatitis B vaccine - Hookworm Infection, Hookworm Disease | Phase 1 | Completed | Baylor College of Medicine | 32 | 2014-11-01 | 2017-05-31 |
| Safety and Immunogenicity Study of Na-GST-1 With or Without CpG Na-GST-1/Alhydrogel®, CpG 10104 - Hookworm Infection, Hookworm Disease | Phase 1 | Completed | Baylor College of Medicine | 24 | 2014-10-01 | 2025-07-04 |
| Hookworm Immune Regulation Project Blood and feces sampling - Hookworm Infection | Not applicable | Unknown | Brugmann University Hospital | 40 | 2014-08-01 | 2021-02-21 |
| Safety and Immunogenicity of the Na-APR-1 Hookworm Vaccine in Healthy Adults Na-APR-1 (M74)/Alhydrogel®, Gluco-Pyranosylphospho-Lipid A Aqueous Formulation - Hookworm Infection, Hookworm Disease | Phase 1 | Completed | Baylor College of Medicine | 40 | 2013-09-01 | 2019-07-31 |
| Safety and Immunogenicity of a Human Hookworm Candidate Vaccine With Different Doses of a Novel Adjuvant 10 μg Na-GST-1/Alhydrogel, 30 μg Na-GST-1/Alhydrogel, 100 μg Na-GST-1/Alhydrogel - Hookworm Infection, Hookworm Disease | Phase 1 | Completed | Baylor College of Medicine | 40 | 2012-05-01 | 2025-01-06 |
| Safety and Immunogenicity of a Human Hookworm Candidate Vaccine With or Without Additional Adjuvant in Brazilian Adults 10 μg Na-GST-1/Alhydrogel, 30 μg Na-GST-1/Alhydrogel, 100 μg Na-GST-1/Alhydrogel - Hookworm Infection, Hookworm Disease | Phase 1 | Completed | Baylor College of Medicine | 102 | 2011-11-01 | 2017-05-31 |
| Prevalence of Hookworm Infection and Community Preparedness for Hookworm Vaccine Trials in Endemic Areas of Brazil Na-ASP-2 Skin Test Reagent - Hookworm Infection | Not applicable | Completed | Albert B. Sabin Vaccine Institute | 87 | 2009-08-01 | 2018-08-01 |
| Development of a Skin Test for the Na-ASP-2 Hookworm Antigen Na-ASP-2 Skin Test Reagent - Hookworm Infection, Allergy | Not applicable | Completed | Albert B. Sabin Vaccine Institute | 12 | 2008-03-01 | 2012-02-23 |
| Phase 1 Trial of Na-ASP-2 Hookworm Vaccine in Previously Infected Brazilian Adults Na-ASP-2 Hookworm Vaccine - Hookworm Infection | Phase 1 | Terminated | Albert B. Sabin Vaccine Institute | 9 | 2007-05-01 | 2012-07-09 |
| Study of Na-ASP-2 Human Hookworm Vaccine in Healthy Adults Without Evidence of Hookworm Infection Na-ASP-2/Alhydrogel Hookworm Vaccine, Saline placebo - Hookworm Infection | Phase 1 | Completed | Baylor College of Medicine | 36 | 2005-04-01 | 2017-05-31 |
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Hookworm Infections (21) · Ancylostomiasis (16) · Anemia, Iron-Deficiency (6) · Trichuriasis (6) · Neglected Diseases (4) · Ascariasis (2) · Enterobiasis (2) · Hypersensitivity (2) · Strongyloidiasis (2) · Lice Infestations (1) · Tungiasis (1)
Helminthiasis (21) · Infections (21) · Nematode Infections (21) · Parasitic Diseases (21) · Secernentea Infections (21) · Strongylida Infections (21) · Adenophorea Infections (6) · Anemia (6) · Anemia, Hypochromic (6) · Enoplida Infections (6) · Hematologic Diseases (6) · Hemic and Lymphatic Diseases (6) · Iron Deficiencies (6) · Iron Metabolism Disorders (6) · Metabolic Diseases (6)
Mebendazole (4) · Albendazole (3) · Bay 44-4400 (2) · Hepatitis B Vaccines (2) · emodepside (2) · oxantel pamoate (2) · Blood Specimen Collection (1) · CPG-oligonucleotide (1) · D-Worm (1) · GLA-AF adjuvant (1) · Granuflex E (1) · Ivermectin (1) · Pyrantel Pamoate (1) · Therapeutics (1)
Baylor College of Medicine (10) · Albert B. Sabin Vaccine Institute (3) · Swiss Tropical & Public Health Institute (3) · Brugmann University Hospital (1) · Centers for Disease Control and Prevention (1) · Jennifer Keiser (1) · London School of Hygiene and Tropical Medicine (1) · Mundo Sano Foundation (1)
United States (6) · Brazil (4) · Gabon (3) · Tanzania (2) · Guatemala (1) · Honduras (1) · Kenya (1) · Laos (1) · Philippines (1) · Vietnam (1)
David Diemert, MD (4) · Ayola Adegnika, MD (3) · David J Diemert, MD (3) · Jennifer Keiser, Professor (2) · Alejandro Javier Krolewiecki, PhD, MD (1) · Byron Arana, MD (1) · Charles Mwandawiro, PhD (1) · David Parenti, MD (1) · Gabriela Matamoros, PhD, MSc, BSc (1) · Gary Simon, M.D., Ph.D (1) · Jeffrey Bethony, PhD (1) · Jennifer Keiser, PhD (1) · Michael J Beach, Ph.D. (1) · Rachel Pullan, PhD (1)
PMID 28464026, PMID 18396361, PMID 22633322, PMID 29673735, PMID 29780848, PMID 32926834, PMID 34597297, PMID 38513684, PMID 40480665, PMID 42486129