2 terminated, 2 unknown, 1 recruiting. 5 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 5 | Terminated 2, Unknown 2, Recruiting 1 |
Follow Heart Failure Acute: new trials by email Literature Review of Heart Failure Acute trials Research Report on Heart Failure Acute
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure Furosemide intravenous solution - Heart Failure, Heart Failure - NYHA II - IV | Phase 4 | Recruiting | Lakeland Regional Health Systems, Inc. | 600 | 2026-04-01 | 2026-04-09 |
| SGLT-2 Inhibitor and High-Dose Furosemide Plus Small-Volume Hypertonic Saline Solution in Acute HF Dapagliflozin tablet, Hypertonic Saline Solution, 1 Ml, Furosemide Injection - Heart Failure Acute, Diabetes Type 2 | Phase 4 | Unknown | University of Palermo | 544 | 2024-06-01 | 2024-06-06 |
| Diuretic and Natriuretic Effect of High-dose Spironolactone in Patients With Acute Heart Failure Spironolactone - Heart Failure Acute, Heart Failure; With Decompensation | Phase 4 | Unknown | Laikο General Hospital, Athens | 50 | 2020-10-20 | 2020-11-10 |
| Diuretic Effect of Metolazone Pre-dosing Versus Concurrent Dosing Metolazone 60 minutes prior to furosemide, Metolazone concurrently with furosemide - Fluid Overload, Heart Failure Acute | Phase 4 | Terminated | University of Maryland, Baltimore | 3 | 2019-01-01 | 2021-10-22 |
| Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic Resistance Metolazone Oral Tablet, Chlorothiazide Injection - Heart Failure, Heart Failure With Reduced Ejection Fraction | Phase 4 | Terminated | University of Virginia | 5 | 2018-06-01 | 2021-02-16 |
Heart Failure (3) · Cardio-Renal Syndrome (1) · Cardiovascular Diseases (1) · Diabetes Mellitus, Type 2 (1) · Edema (1)
Heart Diseases (3) · Cardiovascular Diseases (2) · Diabetes Mellitus (1) · Endocrine System Diseases (1) · Female Urogenital Diseases (1) · Female Urogenital Diseases and Pregnancy Complications (1) · Glucose Metabolism Disorders (1) · Kidney Diseases (1) · Male Urogenital Diseases (1) · Metabolic Diseases (1) · Nutritional and Metabolic Diseases (1) · Pathological Conditions, Signs and Symptoms (1) · Renal Insufficiency (1) · Signs and Symptoms (1) · Urogenital Diseases (1)
Furosemide (3) · Metolazone (2) · Chlorothiazide (1) · Saline Solution, Hypertonic (1) · Sodium-Glucose Transporter 2 Inhibitors (1) · Spironolactone (1) · dapagliflozin (1)
Laikο General Hospital, Athens (1) · Lakeland Regional Health Systems, Inc. (1) · University of Maryland, Baltimore (1) · University of Palermo (1) · University of Virginia (1)
United States (3) · Greece (1)
Anas Bizanti, MD (1) · Andrew Lurie, DO (1) · Brent Reed, PharmD (1) · Giuseppe Miceli, PhD (1) · John Barbetseas, MD (1)
PMID 15963399, PMID 20607462, PMID 21440872, PMID 21885793, PMID 22980301, PMID 26240596, PMID 32139695, PMID 32709292, PMID 32970396, PMID 34447992, PMID 35241246, PMID 36607775