10 completed, 7 recruiting, 3 unknown, 2 terminated. 10 Not applicable, 3 Phase 1, 3 Phase 2, 2 Early Phase 1, 2 Phase 3.
Follow Gulf War Syndrome: new trials by email Literature Review of Gulf War Syndrome trials Research Report on Gulf War Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pycnogenol (French Maritime Pine Bark) for the Treatment of Gulf War Illness Placebo, Pycnogenol, 100mg, Pycnogenol, 200mg - Gulf War Syndrome | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 20 | 2026-11-01 | 2026-09-21 |
| Confirming the Effects of Acupuncture Treatments to Relieve Symptoms of Gulf War Illness Acupuncture - Persian Gulf Syndrome, Gulf War Syndrome | Not applicable | Recruiting | University of Utah | 200 | 2026-02-03 | 2026-04-03 |
| Cranial Electrotherapy Stimulation and Brain Imaging for Gulf War Syndrome Cranial electrical/electrotherapy stimulation (CES), Sham Cranial electrical/electrotherapy stimulation (CES) - Gulf War Syndrome | Not applicable | Recruiting | Emory University | 130 | 2025-09-26 | 2026-04-22 |
| Clinical Evaluation of Montelukast in Veterans With Gulf War Illness Montelukast, Placebo - Gulf War Syndrome | Phase 1 | Recruiting | Baylor College of Medicine | 80 | 2025-08-15 | 2026-09-01 |
| Coenzyme Q10 for Gulf War Illness: A Replication Study PharmaNord Bio-Quinone Active CoQ10 Gold 100mg, PharmaNord Placebo - Gulf War Syndrome, Persian Gulf Syndrome | Phase 3 | Recruiting | University of California, San Diego | 192 | 2024-09-13 | 2026-05-01 |
| Growth Hormone Replacement in Veterans With GWI and AGHD (GWIT) Recombinant human growth hormone - Gulf War Syndrome, Adult Growth Hormone Deficiency | Phase 2 | Recruiting | Baylor College of Medicine | 20 | 2024-03-11 | 2026-05-08 |
| GWICTIC: NAC Mechanistic Study in Gulf War Veterans N-Acetyl Cysteine, Placebo - Gulf War Syndrome | Early Phase 1 | Recruiting | Nova Southeastern University | 170 | 2023-11-30 | 2025-07-08 |
| Confirmation of Diet as a Treatment for Gulf War Illness Dietary Intervention - Gulf War Syndrome, Gulf War Illness | Phase 2 / Phase 3 | Completed | American University | 111 | 2023-03-01 | 2026-10-05 |
| Validating Gulf War Illness Blood Biomarkers Gulf War Syndrome, Gulf War Illness | Recruiting | Roskamp Institute Inc. | 100 | 2022-06-30 | 2025-07-24 | |
| Mitochondrial Cocktail for Gulf War Illness Individualized mitochondrial cocktail, Placebo - Gulf War Syndrome, Persian Gulf Syndrome | Not applicable | Completed | University of California, San Diego | 15 | 2021-04-09 | 2023-04-05 |
| Ketamine in Veterans With Gulf War Illness Ketamine Hydrochloride - Gulf War Syndrome | Early Phase 1 | Terminated | Baylor College of Medicine | 1 | 2021-02-01 | 2022-03-03 |
| Assessing Neuroinflammation in GWI Using MRS Magnetic Resonance Spectroscopic Imaging, Blood draw - Gulf War Syndrome | Completed | University of Alabama at Birmingham | 49 | 2020-12-01 | 2025-01-13 | |
| Long Term Efficacy of Neuronavigation Guided rTMS in Alleviating Gulf War Illness Related Headaches and Pain Symptoms Transcranial Magnetic Stimulation, Sham Transcranial Magnetic Stimulation - Gulf War Syndrome, Gulf War Illness | Not applicable | Unknown | Veterans Medical Research Foundation | 150 | 2019-10-01 | 2023-08-09 |
| Transcranial Direct Current Stimulation for Pain Treatment in Gulf War Illness. Active tDCS, Sham tDCS - Gulf War Syndrome | Not applicable | Terminated | The University of Texas at Dallas | 9 | 2018-03-12 | 2025-02-03 |
| Glutamate Neuro-Excitotoxicity in GWI Low-glutamate diet - Gulf War Syndrome | Not applicable | Completed | American University | 40 | 2017-11-14 | 2021-01-12 |
| Alleviating Headache and Pain in GWI With Neuronavigation Guided rTMS Repetitive transcranial magnetic stimulation, Repetitive transcranial magnetic stimulation (sham) - Gulf War Syndrome, Headache | Not applicable | Completed | Veterans Medical Research Foundation | 90 | 2016-12-01 | 2020-01-18 |
| Glutathione vs. Curcumin Clinical Trial Curcumin, Glutathione, Placebo - Gulf War Syndrome | Phase 1 / Phase 2 | Unknown | South Florida Veterans Affairs Foundation for Research and Education | 75 | 2016-04-01 | 2020-01-29 |
| START & STOPP in GWI 2 submaximal exercise stress tests - Gulf War Syndrome | Completed | Georgetown University | 52 | 2016-02-01 | 2019-06-20 | |
| Mechanisms of Mitochondrial Defects in Gulf War Syndrome Skin biopsy, Blood Collection - Gulf War Syndrome, Mitochondrial Disease | Completed | Medical Neurogenetics, LLC | 26 | 2009-05-01 | 2015-04-13 | |
| Bacterial Overgrowth Associated With Chronic Multisymptom Illness Complex Lactulose Breath Test, Rifaximin, Placebo - Gulf War Syndrome | Phase 1 | Unknown | Henry C. Lin, MD | 210 | 2009-04-01 | 2013-05-01 |
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Persian Gulf Syndrome (23) · Mitochondrial Diseases (3) · Arthralgia (2) · Headache (2) · Myalgia (2) · Dwarfism, Pituitary (1) · Fatigue Syndrome, Chronic (1) · Inflammation (1) · Multiple Chronic Conditions (1) · Neuroinflammatory Diseases (1) · Occupational Diseases (1) · Pain (1) · Patient Acceptance of Health Care (1) · Stress Disorders, Post-Traumatic (1) · War-Related Injuries (1)
Occupational Diseases (22) · War-Related Injuries (22) · Wounds and Injuries (22) · Pathological Conditions, Signs and Symptoms (7) · Nervous System Diseases (5) · Musculoskeletal Diseases (4) · Pathologic Processes (4) · Metabolic Diseases (3) · Muscular Diseases (3) · Neurologic Manifestations (3) · Neuromuscular Diseases (3) · Nutritional and Metabolic Diseases (3) · Signs and Symptoms (3) · Chronic Disease (2) · Disease Attributes (2)
Blood Specimen Collection (2) · Transcranial Magnetic Stimulation (2) · Acetylcysteine (1) · Acupuncture Therapy (1) · Cognitive Behavioral Therapy (1) · Curcumin (1) · Diet Therapy (1) · Glutathione (1) · Growth Hormone (1) · Human Growth Hormone (1) · Ketamine (1) · Magnetic Resonance Spectroscopy (1) · Phlebotomy (1) · Rifaximin (1) · microcrystalline cellulose (1)
Baylor College of Medicine (3) · American University (2) · US Department of Veterans Affairs (2) · University of Alabama at Birmingham (2) · University of California, San Diego (2) · Veterans Medical Research Foundation (2) · Emory University (1) · Georgetown University (1) · Henry C. Lin, MD (1) · Medical Neurogenetics, LLC (1) · Nova Southeastern University (1) · Roskamp Institute Inc. (1) · South Florida Veterans Affairs Foundation for Research and Education (1) · The University of Texas at Dallas (1) · University of Utah (1)
United States (23)
Albert Leung, M.D. (2) · Jarred Younger, PhD (2) · Anna Woodbury, MD, MSc (1) · Beatrice A Golomb, MD, PhD (1) · Drew A Helmer, MD (1) · Elizabeth Balbin (1) · James N Baraniuk (1) · John M Shoffner, MD (1) · Kathleen F Holton, PhD (1) · Kathleen F Holton, PhD, MPH (1) · Kim Sullivan, Ph.D (1) · Laila Abdullah, Ph.D. (1) · Lisa C Krishnamurthy, PhD (1) · Maheen Adamson, Ph.D. (1) · Marijn Lijffijt, PhD (1)
PMID 23898301, PMID 29674668, PMID 30416666, PMID 30791869, PMID 33116195, PMID 39428602, PMID 41137912