5 completed, 2 recruiting, 2 unknown, 2 withdrawn. 7 Not applicable, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 3, Recruiting 2, Not yet recruiting 1, Withdrawn 1 |
| Phase 2 | 1 | Withdrawn 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Gram-negative Bacteremia: new trials by email Literature Review of Gram-negative Bacteremia trials Research Report on Gram-negative Bacteremia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Antimicrobial Resistant Organism Decolonization After Microbiome Perturbation MET-2, Placebo - Gram-negative Bacteremia, Microbial Colonization | Phase 2 | Withdrawn | University Health Network, Toronto | 2026-07-01 | 2026-03-12 | |
| Impact of Real-time MIC (Minimum Inhibitory Concentration) Reporting (<6 Hours) on β-lactam Prescription in Cases of Gram-negative Bacilli Bacteremia in ICU Patients in Real-life Settings SPECIFIC REVEAL® Rapid AST system, antibiotic susceptibility testing on agar medium - Gram-negative Bacteremia, Intensive Care Patients | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 200 | 2025-10-01 | 2025-10-01 |
| A Platform Trial for Gram Negative Bloodstream Infections De-escalation VS No De-escalation, Oral beta-lactams VS non beta-lactams, Central vascular catheter retention VS Central vascular catheter replacement - Gram-negative Bacteremia | Not applicable | Recruiting | Sunnybrook Health Sciences Centre | 2500 | 2024-04-24 | 2026-09-04 |
| Gram-Negative Bloodstream Infection Oral Antibiotic Therapy Trial Intravenous Antibiotics, Oral Antibiotics - Gram-negative Bacteremia | Not applicable | Recruiting | Johns Hopkins University | 1030 | 2024-02-22 | 2026-03-11 |
| Fast Antibiotic Susceptibility Testing for Gram Negative Bacteremia Trial Reveal - Gram-negative Bacteremia, Bloodstream Infection | Not applicable | Completed | Duke University | 899 | 2023-12-22 | 2026-07-28 |
| BALANCE+ Vanguard Phase De-escalation VS No De-escalation, Oral beta-lactams VS non beta-lactams, Central vascular catheter retention VS Central vascular catheter replacement - Gram-negative Bacteremia | Not applicable | Completed | Sunnybrook Health Sciences Centre | 174 | 2023-08-26 | 2024-10-01 |
| CRP and PCT as Predictors of Sepsis Cause PCT levels, CRP levels, White blood cell count - Sepsis, Gram-Positive Bacteremia | Completed | Osijek University Hospital | 81 | 2022-01-05 | 2023-07-18 | |
| Shortened Antibiotic Treatment of 5 Days in Gram-negative Bacteremia Shortened antibiotic treatment, Standard antibiotic treatment - Gram-negative Bacteremia, Urinary Tract Infection Bacterial | Phase 4 | Unknown | Thomas Benfield | 380 | 2020-03-11 | 2023-02-08 |
| Clinical Impact of Fast Phenotypic Antimicrobial Susceptibility Testing on Patients With Gram-Negative Rod Bacteremia Accelerate Pheno, Standard of Care - Gram-negative Bacteremia | Not applicable | Withdrawn | Accelerate Diagnostics, Inc. | 2019-09-30 | 2020-04-14 | |
| Comparison of Solid Organ Transplant Gram-Negative Bacterial Infections, Gram-negative Bacteremia | Unknown | Methodist Health System | 150 | 2018-05-03 | 2020-01-02 | |
| Rapid Identification and Phenotypic Susceptibility Testing for Gram-Negative Bacteremia Accelerate PhenoTest™ BC Kit, Standard Culture and AST - Gram-negative Bacteremia | Not applicable | Completed | Duke University | 500 | 2017-10-09 | 2019-11-26 |
| Clinical Outcomes and Cost of Gram Negative Bacteremia Gram-negative Bacteremia, Bacteremia | Completed | Duke University | 2000 | 2002-01-01 | 2015-11-06 |
Bacteremia (2) · Sepsis (2) · Bacterial Infections (1) · Communicable Diseases (1) · Critical Illness (1) · Escherichia coli Infections (1) · Gram-Negative Bacterial Infections (1) · Healthcare-Associated Pneumonia (1) · Infections (1) · Pseudomonas Infections (1) · Urinary Tract Infections (1)
Infections (6) · Pathologic Processes (6) · Pathological Conditions, Signs and Symptoms (6) · Bacterial Infections and Mycoses (5) · Bacterial Infections (4) · Inflammation (4) · Systemic Inflammatory Response Syndrome (4) · Disease Attributes (3) · Sepsis (2) · Cross Infection (1) · Enterobacteriaceae Infections (1) · Female Urogenital Diseases (1) · Female Urogenital Diseases and Pregnancy Complications (1) · Gram-Negative Bacterial Infections (1) · Iatrogenic Disease (1)
Anti-Bacterial Agents (1) · Leukocyte Count (1) · Platelet Count (1)
Duke University (3) · Sunnybrook Health Sciences Centre (2) · Accelerate Diagnostics, Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · Johns Hopkins University (1) · Methodist Health System (1) · Osijek University Hospital (1) · Thomas Benfield (1) · University Health Network, Toronto (1)
United States (4) · Canada (3) · Israel (2) · Australia (1) · Colombia (1) · Croatia (1) · Denmark (1) · Greece (1) · India (1) · New Zealand (1) · Spain (1)
Nick Daneman, MD (2) · Ritu Banerjee, MD, PhD (2) · Rob Fowler, MD (2) · Bryan Coburn, MD, PhD (1) · Matt Crotty, PharmD (1) · Nenad Neskovic, PhD (1) · Pranita D Tamma, MD, MHS (1) · Sara E Cosgrove, MD, MS (1) · Vance Fowler, MD (1) · Vance G Fowler, MD (1)
PMID 32374822, PMID 37156588, PMID 41225518, PMID 41360461, PMID 41999287
2019 (1), 5UM1AI104681 (1), UM1AI104681 (1)