428 completed, 123 terminated, 108 recruiting, 75 unknown. 881 Phase 2, 282 Phase 1, 16 Phase 3.
Follow Glioblastoma: new trials by email Literature Review of Glioblastoma trials Research Report on Glioblastoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma JBI-778 - Brain Metastases From Solid Tumors, Leptomeningeal Disease | Phase 1 / Phase 2 | Not yet recruiting | Jubilant Therapeutics Inc. | 113 | 2028-04-01 | 2026-08-07 |
| Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG) ADI-PEG 20 (Arginine deiminase pegylated), Temozolomide (TMZ), Standard of Care Radiation Therapy (RT) - Glioblastoma, High-Grade Glioma (WHO III-IV) | Phase 1 / Phase 2 | Not yet recruiting | Sabine Mueller, MD, PhD | 97 | 2027-06-01 | 2026-09-15 |
| DLL3 CAR-T Therapy Targeting Brain Tumors 4SCAR DLL3 T cells - Glioblastoma of Cerebellum | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-01 | 2026-09-01 |
| Metronomic Temozolomide With Dexbrompheniramine for Recurrent High-Grade Glioma/Glioblastoma Dexbrompheniramine, Temozolomide - High Grade Glioma, Glioblastoma | Phase 1 / Phase 2 | Not yet recruiting | University of Nebraska | 41 | 2027-06-01 | 2026-10-05 |
| Comparison of Cerebraca Wafer Plus Temozolomide Versus Temozolomide Alone in Recurrent Glioblastoma Cerebraca wafer, Temozolomide (for relapsed malignant glioma) - Recurrent Glioblastoma, IDH-Wildtype | Phase 2 / Phase 3 | Not yet recruiting | Everfront Biotech Co., Ltd. | 175 | 2027-04-01 | 2026-09-10 |
| IDH1-vac in Patients With Newly Diagnosed IDH1R132H-positive High-grade Astrocytomas IDH1-vac, IS-vac, Temozolomide (TMZ) - Astrocytoma, IDH-Mutant, Grade 3, Astrocytoma, IDH-Mutant, Grade 4 | Phase 2 | Not yet recruiting | German Cancer Research Center | 216 | 2027-02-01 | 2026-10-22 |
| NG101m Adjuvant Therapy in Glioblastoma Patients Intensity-modulated radiation therapy, Temozolomide, NG101m - Glioblastoma Multiforme | Phase 1 / Phase 2 | Not yet recruiting | NeuGATE Theranostics | 52 | 2027-01-01 | 2025-10-21 |
| Disulfiram/Copper Combination In The Treatment of Newly Diagnosed Glioblastoma Multiform Temozolomide, Disulfiram, Copper - Glioblastoma Multiforme | Phase 2 | Not yet recruiting | Olympion Medical Center | 32 | 2027-01-01 | 2025-05-25 |
| Efficacy of Mirdametinib Alone or Combination With Radiotherapy for Germline and Sporadic NF1-Altered High-Grade Glioma mirdametinib with radiation, mirdametinib - Neurofibromatosis 1 (NF1) | Phase 2 | Not yet recruiting | University of Alabama at Birmingham | 55 | 2027-01-01 | 2026-10-05 |
| A Study of SRN-101 Gene Therapy in Adults With Recurrent High-Grade Glioma (ALERT-1) SRN-101 - Recurrent High Grade Gliomas, Glioblastoma (GBM) | Phase 1 / Phase 2 | Not yet recruiting | Siren Biotechnology | 40 | 2026-12-01 | 2026-10-28 |
| Laser Interstitial Thermal Therapy (LiTT) With Cemiplimab or Other Chemotherapy in Recurrent Glioblastomas NeuroBlate® Laser Ablation Laser Interstitial Thermal Therapy, Cemiplimab, Chemotherapy - Glioblastoma, Glioblastoma, IDH-wildtype | Phase 2 | Not yet recruiting | Washington University School of Medicine | 99 | 2026-11-30 | 2026-10-20 |
| Tris-CAR-T Cell Therapy Targeting CD44 and CD133 in Newly Diagnosed Glioblastoma Tris-CAR-T cell injection, Ommaya reservoir implantation, Temozolomide (TMZ) - Newly Diagnosed Glioblastoma, IDH-wildtype | Phase 2 / Phase 3 | Not yet recruiting | Beijing Tiantan Hospital | 60 | 2026-10-15 | 2026-10-14 |
| Phase II Elderly/Frail Pts With Newly Diagnosed or Recurrent Malignant Glioma Treated With Cesium-131 GammaTile® GammaTile® - Glioma, Glioblastoma | Phase 2 | Not yet recruiting | University of California, Irvine | 20 | 2026-10-01 | 2026-09-23 |
| Adebrelimab Plus Temozolomide ± Hyperbaric Oxygen for Primary Glioblastoma Adebrelimab, Temozolomide, Procedure:Hyperbaric Oxygen Therapy - Glioblastoma | Phase 2 | Not yet recruiting | Wei Jiang | 94 | 2026-10-01 | 2026-08-27 |
| Entacapone Plus Bevacizumab for Glioblastoma at First Recurrence Entacapone, Bevacizumab, Placebo - Glioblastoma | Phase 1 / Phase 2 | Not yet recruiting | First Affiliated Hospital of Wenzhou Medical University | 96 | 2026-10-01 | 2026-09-21 |
| Survivin-Targeted Dendritic Cell (DC) Cell Injection for Newly Diagnosed Glioblastoma Survivin-targeted DC Cell Injection - Glioblastoma | Phase 2 | Not yet recruiting | Beijing Tricision Biotherapeutics Inc | 30 | 2026-09-30 | 2026-07-20 |
| Pharmacoscopy for Patients With Refractory Primary Brain Tumors Pharmacoscopy 1.0 - Brain (Nervous System) Cancers, Glioblastoma | Phase 2 | Recruiting | University of Zurich | 40 | 2026-09-11 | 2026-09-21 |
| VISTA: Valproic Acid, Irinotecan, and Simvastatin for Recurrent Glioma Valproic Acid (VPA), Irinotecan, Simvastatin - Glioblastoma, Astrocytoma, IDH-Mutant, Grade 4 | Phase 2 | Recruiting | Inova Health Care Services | 52 | 2026-09-04 | 2026-09-21 |
| A Study of Catequentinib Hydrochloride (AL3818) in Endometrial, LGSOC, STS or GBM Cancers AL58805, AL3818, Temozolomide (TMZ) - Endometrial Neoplasms, Ovarian Neoplasms | Phase 1 / Phase 2 | Not yet recruiting | Advenchen Pharmaceuticals, LLC. | 138 | 2026-09-01 | 2026-09-10 |
| Combination Immunotherapy Treatment for Glioblastoma Including BreakVax ImmunoTreatment (Designed and Manufactured Per Patient), Chemotherapy and Anti PD-1 Therapy BreakVax, Ipilimumab 2.5 mg, Pembrolizumab - Glioblastoma (GBM) | Phase 1 / Phase 2 | Not yet recruiting | BreakBio Corp | 10 | 2026-09-01 | 2026-08-19 |
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Brain Neoplasms (279) · Gliosarcoma (255) · Glioma (232) · Astrocytoma (176) · Central Nervous System Neoplasms (137) · Oligodendroglioma (102) · Recurrence (44) · Neoplasms (32) · Ependymoma (29) · Medulloblastoma (19) · Meningioma (17) · Carcinoma, Non-Small-Cell Lung (15) · Breast Neoplasms (14) · Melanoma (14)
Neoplasms, Glandular and Epithelial (881) · Neoplasms by Histologic Type (879) · Neuroectodermal Tumors (878) · Neoplasms, Germ Cell and Embryonal (877) · Neoplasms, Nerve Tissue (877) · Neoplasms, Neuroepithelial (876) · Neoplasms (849) · Astrocytoma (705) · Glioma (649) · Neoplasms by Site (373) · Nervous System Diseases (349) · Nervous System Neoplasms (345) · Central Nervous System Diseases (293) · Brain Diseases (292) · Central Nervous System Neoplasms (209)
Temozolomide (241) · Bevacizumab (115) · Radiotherapy (109) · Radiation (36) · pembrolizumab (30) · Magnetic Resonance Spectroscopy (29) · Lomustine (28) · Irinotecan (27) · Carmustine (24) · Carboplatin (22) · Surgical Procedures, Operative (22) · Erlotinib Hydrochloride (18) · Nivolumab (16) · Aminolevulinic Acid (14) · Specimen Handling (13)
National Cancer Institute (NCI) (68) · Duke University (31) · M.D. Anderson Cancer Center (23) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (22) · Dana-Farber Cancer Institute (10) · Jonsson Comprehensive Cancer Center (10) · Memorial Sloan Kettering Cancer Center (10) · European Organisation for Research and Treatment of Cancer - EORTC (9) · Northwestern University (9) · Mayo Clinic (8) · New Approaches to Brain Tumor Therapy Consortium (8) · Novartis Pharmaceuticals (8) · Radiation Therapy Oncology Group (8) · Alliance for Clinical Trials in Oncology (7) · Assistance Publique - Hôpitaux de Paris (7)
United States (577) · France (55) · China (54) · Germany (49) · Canada (46) · Italy (43) · Spain (42) · Switzerland (39) · United Kingdom (35) · Belgium (24) · Netherlands (24) · Australia (23) · South Korea (18) · Denmark (14) · Israel (14)
Annick Desjardins, MD, FRCPC (9) · David Peereboom, MD (9) · David A. Reardon, MD (8) · Evanthia Galanis (5) · Jeffrey Raizer, MD (5) · John Boockvar, MD (5) · Patrick Wen, MD (5) · Stanislaw R. Burzynski, MD, PhD (5) · Stuart A. Grossman, MD (5) · David Reardon, MD (4) · Henry S. Friedman, MD (4) · Howard Fine, MD (4)
PMID 39777725, PMID 12749708, PMID 23817721, PMID 25098701, PMID 25113840, PMID 27580889, PMID 34331515, PMID 37142373, PMID 37540556, PMID 39571596, PMID 10334539, PMID 11772431, PMID 14670747, PMID 14769135, PMID 14769136, PMID 14769138, PMID 15073861, PMID 15292713, PMID 15758009, PMID 15809479, PMID 16012795, PMID 16034522, PMID 16053699, PMID 16133802, PMID 16170172, PMID 16443947, PMID 16549835, PMID 16648043, PMID 16750317, PMID 16817692, PMID 16877732, PMID 16877733, PMID 16914578, PMID 17031561, PMID 17317837, PMID 17470857, PMID 17882417, PMID 18094423, PMID 18182667, PMID 18215105, PMID 18403492, PMID 18661102, PMID 18723297, PMID 18775433, PMID 18797818, PMID 18824712, PMID 18955445, PMID 18981004, PMID 18981465, PMID 19075262
U01CA062475 (14), U10CA025224 (10), 2009 (7), U01CA062399 (7), U10CA021661 (7), 2015 (6), U01CA137443 (6), U10CA180821 (6), U10CA180868 (6), 2014 (5), 2023 (5), 2018 (4), 2016 (3), 2017 (3), 2019 (3)