4 active not recruiting, 1 completed, 1 not yet recruiting, 1 recruiting. 8 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 8 | Active not recruiting 4, Completed 1, Not yet recruiting 1, Recruiting 1, Unknown 1 |
Follow Giant Cell Tumors: new trials by email Literature Review of Giant Cell Tumors trials Research Report on Giant Cell Tumors
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of Emactuzumab for Tenosynovial Giant Cell Tumor (TGCT) Emactuzumab, Placebo - TGCT | Phase 3 | Active not recruiting | SynOx Therapeutics Limited | 128 | 2024-10-09 | 2026-07-29 |
| Study of Pimicotinib (ABSK021) for Tenosynovial Giant Cell Tumor (MANEUVER) Pimicotinib(ABSK021), Placebo - Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis | Phase 3 | Active not recruiting | Abbisko Therapeutics Co, Ltd | 94 | 2023-04-27 | 2026-05-04 |
| A Study to Evaluate the Efficacy and Safety of Narlumosbart (JMT103) in Patients With Giant Cell Tumor of Bone Narlumosbart, Denosumab - Giant Cell Tumor of Bone | Phase 3 | Not yet recruiting | Shanghai JMT-Bio Inc. | 146 | 2023-04-01 | 2023-04-19 |
| Study of Vimseltinib for Tenosynovial Giant Cell Tumor Vimseltinib, Placebo - Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis | Phase 3 | Active not recruiting | Deciphera Pharmaceuticals, LLC | 123 | 2021-10-14 | 2026-03-20 |
| A Study of the Efficacy and Safety of Pexidartinib in Adult Subjects With TGCT Pexidartinib - Tenosynovial Giant Cell Tumor | Phase 3 | Active not recruiting | Daiichi Sankyo Co., Ltd. | 40 | 2020-09-25 | 2026-06-26 |
| Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone Zoledronic Acid - Giant Cell Tumor of Bone | Phase 3 | Recruiting | St. Louis University | 120 | 2018-05-03 | 2026-04-22 |
| Characteristics and Mechanism of Denosumab-treated Giant Cell Tumor of Bone Denosumab - Giant Cell Tumor of Bone | Phase 3 | Unknown | Hebei Medical University Third Hospital | 30 | 2016-05-01 | 2017-08-24 |
| Phase 3 Study of Pexidartinib for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS) Pexidartinib, Placebo - Pigmented Villonodular Synovitis, Giant Cell Tumors of the Tendon Sheath | Phase 3 | Completed | Daiichi Sankyo | 120 | 2015-05-11 | 2022-05-11 |
Giant Cell Tumor of Tendon Sheath (4) · Synovitis, Pigmented Villonodular (4) · Giant Cell Tumor of Bone (3) · Synovitis (1)
Neoplasms (8) · Neoplasms by Histologic Type (8) · Neoplasms, Connective Tissue (8) · Neoplasms, Connective and Soft Tissue (8) · Joint Diseases (5) · Muscular Diseases (5) · Musculoskeletal Diseases (5) · Tendinopathy (5) · Synovitis (4) · Neoplasms, Bone Tissue (3) · Giant Cell Tumor of Tendon Sheath (1)
Denosumab (2) · pexidartinib (2) · Zoledronic Acid (1) · emactuzumab (1)
Abbisko Therapeutics Co, Ltd (1) · Daiichi Sankyo (1) · Daiichi Sankyo Co., Ltd. (1) · Deciphera Pharmaceuticals, LLC (1) · Hebei Medical University Third Hospital (1) · Shanghai JMT-Bio Inc. (1) · St. Louis University (1) · SynOx Therapeutics Limited (1)
Canada (5) · United States (5) · China (4) · Italy (4) · Netherlands (4) · Spain (4) · France (3) · Poland (3) · United Kingdom (3) · Australia (2) · Germany (2) · Switzerland (2) · Taiwan (2) · Belgium (1) · Denmark (1)
Jean Y Blay, Prof, MD (1) · Xiaohui Niu, B.M. (1) · Zhuang Zhou, Ph.D (1)
PMID 27041409, PMID 31229240, PMID 32755241, PMID 33289960, PMID 36001000, PMID 37593881, PMID 38843860, PMID 39287124, PMID 40841499, PMID 41796601, PMID 42132251, PMID 42473802, PMID 42872549
2014 (1)