14 recruiting, 9 not yet recruiting, 4 completed, 1 enrolling by invitation. 4 Not applicable, 4 Phase 3, 3 Phase 2, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Not yet recruiting 2, Recruiting 2 |
| Phase 3 | 4 | Completed 2, Not yet recruiting 2 |
| Phase 2 | 3 | Recruiting 2, Not yet recruiting 1 |
| Phase 4 | 2 | Enrolling by invitation 1, Recruiting 1 |
Follow Giant Cell Arteritis (GCA): new trials by email Literature Review of Giant Cell Arteritis (GCA) trials Research Report on Giant Cell Arteritis (GCA)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Aspirin for the Prevention of Ischemic Complications in Giant Cell Arteritis Acetyl Salicylic Acid (ASA), Placebo - Giant Cell Arteritis (GCA), Acute Coronary Syndrome (ACS) | Phase 3 | Not yet recruiting | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 120 | 2027-10-01 | 2026-10-30 |
| Long-Axial Field of View (LAFOV) [18F]FDG PET/CT Imaging in Large Vessel Vasculitis (LVV): Protocol Optimisation Study. [18F]FDG Long-Axial Field of View (LAFOV)-PET/CT, CT Angiogram, MR Angiogram - Large Vessel Vasculitis, Takayasu Arteritis | Not applicable | Not yet recruiting | Imperial College London | 18 | 2026-12-01 | 2026-10-16 |
| Mapping B-cell Biology Across the Cardiovascular Territories of Giant Cell Arteritis: Towards a New Therapeutic Approach (RituxiMAP GCA) Zirconium Zr 89 labelled rituximab - Giant Cell Arteritis (GCA) | Not yet recruiting | University of Edinburgh | 30 | 2026-10-01 | 2026-06-16 | |
| Treatment for Giant Cell Arteritis With Tocilizumab and 8 as Compared to 26 Weeks of Prednisone Prednisone - Giant Cell Arteritis (GCA) | Phase 3 | Not yet recruiting | Insel Gruppe AG, University Hospital Bern | 178 | 2026-07-01 | 2026-05-01 |
| Kinetics of C-Reactive Protein in Giant Cell Arteritis Following Glucocorticoid Initiation: A Pilot Study (GIDEON) Blood tests to measure CRP - Giant Cell Arteritis (GCA) | Not applicable | Not yet recruiting | University Hospital, Limoges | 40 | 2026-06-22 | 2026-07-22 |
| Bosentan in the Treatment of Giant Cell Arteritis Bosentan, Glucocorticoids - Giant Cell Arteritis (GCA) | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 40 | 2026-06-01 | 2026-05-06 |
| Disease Activity Monitoring in Patients With Giant Cell Arteritis Study Giant Cell Arteritis (GCA) | Recruiting | University of Aarhus | 175 | 2026-05-06 | 2026-08-31 | |
| The VGR GCA Cohort: Ultrasound, Biopsy and Biomarkers - Novel Methods for Diagnosis, Monitoring and Prognosis in Giant Cell Arteritis. Giant Cell Arteritis (GCA) | Recruiting | Vastra Gotaland Region | 340 | 2026-03-01 | 2026-04-15 | |
| Upadacitinib in Giant Cell Arteritis (GCA) With Active Large-vessel Involvement. Giant Cell Arteritis (GCA) | Not yet recruiting | Groupe français d'étude des Maladies Inflammatoires de loeil | 80 | 2026-03-01 | 2026-01-21 | |
| Halo Sign Vanishing Time After Steroids Outbreak in GCA Patients Doppler Ultrasound - Giant Cell Arteritis (GCA), Doppler Ultrasound | Not applicable | Recruiting | Centre Hospitalier le Mans | 64 | 2026-02-27 | 2026-07-17 |
| Study of the Association Between Sacroiliitis/Axial Spondylarthritis and Giant Cell Arteritis/ Polymyalgia Rheumatica Description of population - Giant Cell Arteritis (GCA), Spondylarthritis | Not yet recruiting | Hôpital NOVO | 10 | 2026-02-01 | 2026-02-06 | |
| Orbital Vascular Inflammation in Ischemic Optic Neuropathy and Giant Cell Arteritis Positron Emission Tomography / Magnetic Resonance Imaging - Giant Cell Arteritis (GCA), Ischemic Optic Neuropathy | Recruiting | Copenhagen University Hospital, Rigshospitalet | 122 | 2026-01-14 | 2026-05-07 | |
| Tocilizumab Discontinuation Versus Dose Reduction for Patients With Well-Controlled Giant Cell Arteritis Tocilizumab, Discontinue Tocilizumab - Giant Cell Arteritis (GCA) | Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 78 | 2026-01-05 | 2026-08-10 |
| oPtic Nerve Sheath Evaluation in gianT Cell aRtheritis by UltraSound orbital ultrasound - Giant Cell Arteritis (GCA) | Not applicable | Recruiting | Hôpital NOVO | 190 | 2025-09-04 | 2025-09-12 |
| Clinical Assessment for Rheumatologic Disease - Research and Advancement in Safety and Efficacy Ex Vivo Assay - Rheumatic Diseases, Rheumatoid Arthritis (RA) | Recruiting | University of Bonn | 120 | 2025-04-01 | 2025-09-02 | |
| Dapagliflozin and Endothelin Receptor Antagonism in Large Vessel Vasculitis (DERAIL-LVV) Bosentan and dapagliflozin - Large Vessel Vasculitis, Giant Cell Arteritis (GCA) | Phase 2 | Recruiting | University of Edinburgh | 60 | 2025-03-21 | 2026-01-14 |
| Performance of a Fast-track Pathway for Giant Cell Arteritis Diagnosis Giant Cell Arteritis (GCA) | Recruiting | Groupe Hospitalier de la Rochelle Ré Aunis | 100 | 2025-02-14 | 2025-06-20 | |
| A Registry Study Assessing PRO, Dosing Patterns, and Safety of Vunakizumab in Patients With General Rheumatic Diseases. Ankylosing Spondylitis (AS), Psoriatic Arthritis (PsA) | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 10000 | 2025-01-30 | 2025-01-09 | |
| Vaccination Against Herpes Zoster in Patients With Inflammatory Rheumatic Diseases Shingrix, vaccination with 2 doses of Shingrix vaccine - Systemic Vasculitis, Spondylarthropathies | Phase 4 | Enrolling by invitation | Region Skane | 240 | 2024-12-17 | 2025-01-10 |
| AYLo - AutoimmunitY and Loss of y Single nucleotide polymorphisms (SNP), 3'mRNA sequencing, Enzyme-linked immunosorbent assay (ELISA) and Legendplex Array - Giant Cell Arteritis (GCA), Polymyalgia Rheumatica (PMR) | Recruiting | University of Bonn | 500 | 2024-11-15 | 2025-04-10 |
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Giant Cell Arteritis (28) · Polymyalgia Rheumatica (8) · Arthritis, Psoriatic (4) · Takayasu Arteritis (3) · Vasculitis (3) · Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (2) · Arthritis, Juvenile (2) · Arthritis, Rheumatoid (2) · Cardiovascular Diseases (2) · Connective Tissue Diseases (2) · Myositis (2) · Acute Coronary Syndrome (1) · Adrenal Insufficiency (1) · Aortitis (1) · Arthritis (1)
Arteritis (28) · Autoimmune Diseases of the Nervous System (28) · Brain Diseases (28) · Central Nervous System Diseases (28) · Cerebrovascular Disorders (28) · Immune System Diseases (28) · Nervous System Diseases (28) · Skin Diseases (28) · Skin Diseases, Vascular (28) · Skin and Connective Tissue Diseases (28) · Vascular Diseases (28) · Vasculitis, Central Nervous System (28) · Autoimmune Diseases (27) · Cardiovascular Diseases (26) · Vasculitis (25)
Bosentan (2) · Adrenal Cortex Hormones (1) · Data Collection (1) · Flow Cytometry (1) · Glucocorticoids (1) · Hydrocortisone (1) · Magnetic Resonance Imaging (1) · Polymorphism, Single Nucleotide (1) · Positron-Emission Tomography (1) · Prednisone (1) · Tomography, Optical Coherence (1) · Vaccination (1) · dapagliflozin (1) · secukinumab (1) · tocilizumab (1)
Groupe français d'étude des Maladies Inflammatoires de loeil (3) · Hôpital NOVO (2) · University of Bonn (2) · University of Edinburgh (2) · AbbVie (1) · Assistance Publique - Hôpitaux de Paris (1) · Centre Hospitalier Universitaire Dijon (1) · Centre Hospitalier le Mans (1) · Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal (1) · Copenhagen University Hospital, Rigshospitalet (1) · Groupe Hospitalier de la Rochelle Ré Aunis (1) · Imperial College London (1) · Insel Gruppe AG, University Hospital Bern (1) · Marianne Andersen (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1)
France (11) · Denmark (5) · Germany (5) · United Kingdom (5) · Sweden (4) · Switzerland (4) · Canada (3) · United States (3) · Australia (2) · Austria (2) · Belgium (2) · Czechia (2) · Greece (2) · Hungary (2) · Israel (2)
Alexander Isaak, PD Dr. (1) · Jean-Paul Makhzoum, MD (1) · Julian Luetkens, Prof. Dr. (1) · Lisa Christ, Dr. med. (1) · Marianne S Andersen (1) · Sebastian H Unizony, M.D. (1) · Simon Petzinna, Dr. (1) · Tara D Barwick, MBChB MSc FRCR FRCP (1)
PMID 26952547, PMID 28745999, PMID 28756037, PMID 30392702, PMID 31270110, PMID 36508210, PMID 38840219, PMID 40174237, PMID 41537566, PMID 41638742, PMID 42234457, PMID 42667206
2023 (2), 2017 (1), 2025 (1)