7 unknown, 4 completed, 1 terminated. 12 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 12 | Unknown 7, Completed 4, Terminated 1 |
| Phase 2 | 4 | Unknown 4 |
Follow Gestational Trophoblastic Disease: new trials by email Literature Review of Gestational Trophoblastic Disease trials Research Report on Gestational Trophoblastic Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Second Uterine Evacuation for Low-risk Gestational Trophoblastic Neoplasia Uterine curettage, Chemotherapy - Gestational Trophoblastic Neoplasia, Molar Pregnancy | Phase 3 | Unknown | Brigham and Women's Hospital | 150 | 2021-02-11 | 2022-05-27 |
| Letrozole as a Prophylaxis From GTN for Complete Mole Patients Suction evacuation, Letrozole tablets - Gestational Trophoblastic Disease | Phase 2 / Phase 3 | Unknown | Zagazig University | 200 | 2020-06-01 | 2022-07-12 |
| Combination of Methotrexate(MTX) and Actinomycin(ACTD) in the Low Risk Gestational Trophoblastic Neoplasma （GTN） Patients With Score of 5-6 MTX, MTX+ACTD - Gestational Trophoblastic Tumor, Effects of Chemotherapy | Phase 2 / Phase 3 | Unknown | Women's Hospital School Of Medicine Zhejiang University | 300 | 2019-03-08 | 2019-03-21 |
| Rescue Regimen and High Dose Methotrexate in Management of Presistent Gestational Trophoplastic Neoplasia rescue regimen, high dose methotrxate - Gestational Trophoblastic Disease | Phase 2 / Phase 3 | Unknown | Assiut University | 170 | 2017-10-01 | 2017-09-13 |
| Study of Paclitaxel Plus Cisplatin as the First-line Chemotherapy in High Risk Gestational Trophoblastic Tumor Etoposide, actinomycin D, methotrexate - Gestational Trophoblastic Neoplasms | Phase 3 | Unknown | Weiguo Lv | 214 | 2016-03-01 | 2022-06-03 |
| Surgery Plus Single Agent Chemotherapy Versus Primary Chemotherapy for Gestational Trophoblastic Neoplasms Total abdominal hysterectomy and methotrexate, Methotrexate plus folinic acid alone - Gestational Trophoblastic Neoplasms | Phase 2 / Phase 3 | Unknown | Maher elesawi kamel elesawi | 20 | 2015-09-01 | 2017-03-22 |
| Methotrexate Single-dose Treatment and Methotrexate/Actinomycin-D Single-dose Treatment in Low-Risk Gestational Trophoblastic Neoplasia MTX 1, MTX 2, Act-d - Gestational Trophoblastic Disease, Gestational Trophoblastic Neoplasia | Phase 3 | Unknown | Ding Ma | 300 | 2012-12-01 | 2019-12-24 |
| Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia Dactinomycin, Leucovorin Calcium, Methotrexate - Choriocarcinoma, FIGO Stage I Gestational Trophoblastic Tumor | Phase 3 | Completed | GOG Foundation | 57 | 2012-06-18 | 2022-08-12 |
| RCT on the Efficacy of Methotrexate for the Prevention of GTD Methotrexate, Vitamin B Complex - Hydatidiform Mole | Phase 3 | Completed | University of the Philippines | 99 | 2011-12-01 | 2020-04-17 |
| Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant moxifloxacin hydrochloride, Placebo - Breast Cancer, Chronic Myeloproliferative Disorders | Phase 3 | Terminated | OHSU Knight Cancer Institute | 240 | 2006-05-01 | 2017-05-09 |
| Amifostine in Treating Peripheral Neuropathy in Patients Who Have Received Chemotherapy for Cancer amifostine trihydrate - Gestational Trophoblastic Tumor, Neurotoxicity | Phase 3 | Completed | Gynecologic Oncology Group | 100 | 2003-03-01 | 2013-07-09 |
| Methotrexate Compared With Dactinomycin in Treating Patients With Gestational Trophoblastic Neoplasia Dactinomycin, Methotrexate - Good Prognosis Metastatic Gestational Trophoblastic Tumor, Hydatidiform Mole | Phase 3 | Completed | Gynecologic Oncology Group | 240 | 1999-06-01 | 2018-05-15 |
Hydatidiform Mole (6) · Blast Crisis (1) · Breast Neoplasms (1) · Burkitt Lymphoma (1) · Carcinoma, Ovarian Epithelial (1) · Choriocarcinoma (1) · Congenital Abnormalities (1) · Drug-Related Side Effects and Adverse Reactions (1) · Hodgkin Disease (1) · Infections (1) · Leukemia (1) · Leukemia, Hairy Cell (1) · Leukemia, Lymphocytic, Chronic, B-Cell (1) · Leukemia, Myeloid, Accelerated Phase (1)
Female Urogenital Diseases and Pregnancy Complications (12) · Neoplasms (12) · Neoplasms by Histologic Type (12) · Neoplasms, Germ Cell and Embryonal (12) · Pregnancy Complications (12) · Pregnancy Complications, Neoplastic (12) · Trophoblastic Neoplasms (12) · Urogenital Diseases (12) · Carcinoma (2) · Chemically-Induced Disorders (2) · Neoplasms, Glandular and Epithelial (2) · Adenocarcinoma (1) · Adnexal Diseases (1) · Blood Protein Disorders (1)
Methotrexate (6) · Dactinomycin (4) · Drug Therapy (2) · Leucovorin (2) · Vacuum Curettage (2) · merphos (2) · Amifostine (1) · Carboplatin (1) · Cisplatin (1) · Cyclophosphamide (1) · Etoposide (1) · Letrozole (1) · Moxifloxacin (1) · Paclitaxel (1) · Surgical Procedures, Operative (1)
Gynecologic Oncology Group (2) · Assiut University (1) · Brigham and Women's Hospital (1) · Ding Ma (1) · GOG Foundation (1) · Maher elesawi kamel elesawi (1) · OHSU Knight Cancer Institute (1) · University of the Philippines (1) · Weiguo Lv (1) · Women's Hospital School Of Medicine Zhejiang University (1) · Zagazig University (1)
United States (4) · China (3) · Egypt (2) · Brazil (1) · Canada (1) · Japan (1) · Philippines (1) · South Korea (1) · United Kingdom (1)
Agnes L. Soriano-Estrella, MD (1) · Antonio Braga, MD, PhD (1) · Joseph Bubalo, PharmD, BCPS, BCOP (1) · Julian C Schink (1) · Mohamed A Alabiad, MD (1) · Raymond Osborne (1) · Steven C. Plaxe, MD (1) · Weiguo Lu, MD. (1) · Xing Xie, MD, PhD (1)
U10CA027469 (2), P30CA069533 (1), U10CA180868 (1)