30 completed, 14 unknown, 9 recruiting, 5 terminated. 27 Phase 2, 12 Phase 3, 8 Not applicable, 6 Phase 1, 1 Phase 4.
Follow Gestational Trophoblastic Disease: new trials by email Literature Review of Gestational Trophoblastic Disease trials Research Report on Gestational Trophoblastic Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Uterine Artery Doppler Flow Velocimetry Parameters for Predicting the Occurrence of Persistent Gestational Trophoblastic Neoplasia After Evacuation of Complete Hydatiform Mole Gestational Trophoblastic Neoplasia, Complete Hydatiform Mole | Not yet recruiting | Minia University | 175 | 2026-01-10 | 2026-01-12 | |
| IMMUNORARE5: A National Platform of 5 Academic Phase II Trials Coordinated by Lyon University Hospital to Assess the Safety and the Efficacy of the IMMUNOtherapy With Domvanalimab + Zimberelimab Combination in Patients With Advanced RARE Cancers DOMVANALIMAB + ZIMBERELIMAB, DOMVANALIMAB + ZIMBERELIMAB + FOLFOX-4 - Peritoneal Mesothelioma, Gestational Trophoblastic Tumor | Phase 2 | Active not recruiting | Hospices Civils de Lyon | 27 | 2025-10-01 | 2026-06-25 |
| A Multi-center Cohort Study of Hydatidiform Mole in China (CN-HM-01) No intervention - Hydatidiform Mole | Recruiting | Obstetrics & Gynecology Hospital of Fudan University | 1489 | 2025-07-09 | 2025-10-02 | |
| Toripalimab Plus Actinomycin-D As Fist-Line Treatment for GTN with FIGO Score 7 Toripalimab, Actinomycin-D - Gestational Trophoblastic Neoplasia | Phase 2 | Recruiting | Peking Union Medical College Hospital | 17 | 2024-12-01 | 2024-12-31 |
| Clinical Specialty Queue For Gestational Trophoblastic Neoplasia Gestational Trophoblastic Neoplasia | Recruiting | Women's Hospital School Of Medicine Zhejiang University | 1000 | 2024-11-04 | 2024-11-12 | |
| The Psychological Impact of GTN on Women Who Have Completed Chemotherapy Treatment Gestational Trophoblastic Neoplasia | Recruiting | Sheffield Teaching Hospitals NHS Foundation Trust | 20 | 2024-05-15 | 2025-02-21 | |
| ASk Questions in GYnecologic Oncology (ASQ-GYO) Administration of the ASk Questions in GYnecologic Oncology (ASQ-GYO) Question Prompt List - Ovarian Cancer, Endometrial Cancer | Not applicable | Completed | Ira Winer | 68 | 2024-04-04 | 2026-08-20 |
| A Feasibility Window Study of Pembrolizumab Prior to Second Evacuation for Post-molar Gestational Trophoblastic Neoplasia Pembrolizumab - Gestational Trophoblastic Disease, Gestational Trophoblastic Neoplasia | Phase 2 | Unknown | Imperial College London | 20 | 2024-02-14 | 2024-04-17 |
| Toripalimab Plus Actinomycin-D as Fist-Line Treatment for GTN With FIGO Score 5-6 Toripalimab, Actinomycin-D - Gestational Trophoblastic Neoplasia | Not applicable | Recruiting | Peking Union Medical College Hospital | 40 | 2023-09-12 | 2025-02-06 |
| Dostarlimab in Chemoresistant Gestational Trophoblastic Neoplasia Dostarlimab - Gestational Trophoblastic Neoplasia | Phase 2 | Withdrawn | University of Miami | 2023-03-01 | 2023-02-28 | |
| A Cohort Study of Hydatidiform Mole No intervention - Hydatidiform Mole | Not yet recruiting | Women's Hospital School Of Medicine Zhejiang University | 800 | 2022-12-01 | 2022-12-08 | |
| Camrelizumab Plus Apatinib in Patients With High-risk Gestational Trophoblastic Neoplasia Camrelizumab plus apatinib CohortA, Camrelizumab plus apatinib Cohort B - Gestational Trophoblastic Neoplasia | Phase 2 | Recruiting | Peking Union Medical College Hospital | 70 | 2022-01-27 | 2026-02-05 |
| The Accuracy of Ultrasound Diagnosis of Hydatidiform Moles Hydatidiform Mole (Diagnosis), Abortion, Spontaneous | Unknown | King's College Hospital NHS Trust | 500 | 2021-10-19 | 2024-06-11 | |
| The Registry of Oncology Outcomes Associated With Testing and Treatment Biomarker Testing (L), Systemic Treatment (T), Patient Reported Outcomes (P) - Adenocarcinoma, Adenocystic Carcinoma | Completed | Taproot Health | 167 | 2021-05-05 | 2024-12-18 | |
| Study of PD-1 Antibody and Bevacizumab in the Treatment of High-risk GTN After Combined Chemotherapy PD-1 inhibitor， bevacizumab - Gestational Trophoblastic Neoplasia | Phase 2 | Unknown | Women's Hospital School Of Medicine Zhejiang University | 20 | 2021-04-15 | 2022-06-03 |
| Second Uterine Evacuation for Low-risk Gestational Trophoblastic Neoplasia Uterine curettage, Chemotherapy - Gestational Trophoblastic Neoplasia, Molar Pregnancy | Phase 3 | Unknown | Brigham and Women's Hospital | 150 | 2021-02-11 | 2022-05-27 |
| Biweekly Actinomycin-D Treatment or Multi-day Methotrexate Protocol in Low-risk Gestational Trophoblastic Neoplasia Methotrexate, Leucovorin, Dactinomycin - Gestational Trophoblastic Tumor, Gestational Trophoblastic Neoplasia | Not applicable | Active not recruiting | xiang yang | 228 | 2020-09-29 | 2025-08-11 |
| Letrozole as a Prophylaxis From GTN for Complete Mole Patients Suction evacuation, Letrozole tablets - Gestational Trophoblastic Disease | Phase 2 / Phase 3 | Unknown | Zagazig University | 200 | 2020-06-01 | 2022-07-12 |
| Phase 2 Trial for Chemo-Resistant Gestational Trophoblastic Neoplasias With Pembrolizumab (CR-GTP) Pembrolizumab Injection [Keytruda] - Gestational Trophoblastic Neoplasia | Phase 2 | Unknown | CHA University | 15 | 2020-06-01 | 2020-03-11 |
| Camrelizumab Combined With Apatinib for Recurrent Resistant GTN Apatinib, Camrelizumab - Gestational Trophoblastic Disease | Phase 2 | Completed | Peking Union Medical College Hospital | 20 | 2019-08-08 | 2021-07-30 |
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Breast Neoplasms (19) · Carcinoma, Ovarian Epithelial (18) · Ovarian Neoplasms (17) · Hydatidiform Mole (16) · Testicular Neoplasms (16) · Neuroblastoma (15) · Lymphoma (14) · Lymphoma, Non-Hodgkin (14) · Multiple Myeloma (14) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (14) · Testicular Germ Cell Tumor (14) · Burkitt Lymphoma (13) · Hodgkin Disease (13) · Leukemia (13)
Female Urogenital Diseases and Pregnancy Complications (65) · Neoplasms by Histologic Type (65) · Neoplasms, Germ Cell and Embryonal (65) · Pregnancy Complications, Neoplastic (65) · Urogenital Diseases (65) · Pregnancy Complications (64) · Trophoblastic Neoplasms (62) · Neoplasms (59) · Neoplasms, Glandular and Epithelial (29) · Carcinoma (27) · Neoplasms by Site (27) · Female Urogenital Diseases (26) · Genital Diseases (26) · Urogenital Neoplasms (26) · Endocrine System Diseases (25)
Methotrexate (9) · Dactinomycin (8) · Drug Therapy (4) · Vacuum Curettage (4) · Flow Cytometry (3) · Leucovorin (3) · camrelizumab (3) · Alemtuzumab (2) · Carboplatin (2) · Cyclophosphamide (2) · Etoposide (2) · Filgrastim (2) · Immunologic Techniques (2) · Methylprednisolone (2) · Pemetrexed (2)
Gynecologic Oncology Group (6) · Women's Hospital School Of Medicine Zhejiang University (6) · Fred Hutchinson Cancer Center (5) · Peking Union Medical College Hospital (4) · Hospices Civils de Lyon (2) · OHSU Knight Cancer Institute (2) · Ohio State University Comprehensive Cancer Center (2) · Vanderbilt-Ingram Cancer Center (2) · Abramson Cancer Center at Penn Medicine (1) · Assiut University (1) · Barbara Ann Karmanos Cancer Institute (1) · Baylor College of Medicine (1) · Brigham and Women's Hospital (1) · CHA University (1) · Cancer Treatment Centers of America (1)
United States (36) · China (13) · United Kingdom (4) · Canada (2) · Egypt (2) · France (2) · South Korea (2) · Australia (1) · Brazil (1) · Guam (1) · India (1) · Italy (1) · Japan (1) · Norway (1) · Philippines (1)
Allan Covens, MD (2) · Joseph Bubalo, PharmD, BCPS, BCOP (2) · Raymond Osborne (2) · Agnes L. Soriano-Estrella, MD (1) · Anastasios Raptis, MD (1) · Antonio Braga, MD, PhD (1) · Barbara Andersen, PhD (1) · Brian Engelhardt, MD (1) · Charles Theuer, MD, PhD (1) · Daniel H. Sterman, MD (1) · David Hockenbery, MD (1) · David Kushner (1) · David Miller, MD (1) · David S. Miller, MD (1) · Ehsan Ghorani (1)
PMID 11677152, PMID 13129680, PMID 14550593, PMID 15814645, PMID 15979551, PMID 16900525, PMID 18039680, PMID 20068553, PMID 24105472, PMID 24105752, PMID 27500329, PMID 29149611, PMID 31969335, PMID 32460997, PMID 33362722, PMID 33882143, PMID 34380663, PMID 34624252, PMID 34716198, PMID 37612621, PMID 38243705, PMID 38358334, PMID 39067873, PMID 39343510, PMID 39417692, PMID 39583952, PMID 39856213, PMID 40082377, PMID 40382972, PMID 40402690, PMID 40543844, PMID 40588371, PMID 41672597, PMID 41892875, PMID 41995270, PMID 42499790
U10CA027469 (3), U10CA180868 (3), P30CA068485 (2), P30CA069533 (2), P30CA014520 (1), P30CA016087 (1), P30CA022453 (1), P30CA043703 (1), R21CA135005 (1), R21CA149675 (1), U01CA076642 (1), U10CA180888 (1)