12 completed, 7 unknown, 3 recruiting, 2 active not recruiting. 27 Phase 2, 4 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 27 | Completed 12, Unknown 7, Recruiting 3, Active not recruiting 2, Terminated 2, Withdrawn 1 |
| Phase 3 | 4 | Unknown 4 |
| Phase 1 | 2 | Completed 2 |
Follow Gestational Trophoblastic Disease: new trials by email Literature Review of Gestational Trophoblastic Disease trials Research Report on Gestational Trophoblastic Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| IMMUNORARE5: A National Platform of 5 Academic Phase II Trials Coordinated by Lyon University Hospital to Assess the Safety and the Efficacy of the IMMUNOtherapy With Domvanalimab + Zimberelimab Combination in Patients With Advanced RARE Cancers DOMVANALIMAB + ZIMBERELIMAB, DOMVANALIMAB + ZIMBERELIMAB + FOLFOX-4 - Peritoneal Mesothelioma, Gestational Trophoblastic Tumor | Phase 2 | Active not recruiting | Hospices Civils de Lyon | 27 | 2025-10-01 | 2026-06-25 |
| Toripalimab Plus Actinomycin-D As Fist-Line Treatment for GTN with FIGO Score 7 Toripalimab, Actinomycin-D - Gestational Trophoblastic Neoplasia | Phase 2 | Recruiting | Peking Union Medical College Hospital | 17 | 2024-12-01 | 2024-12-31 |
| A Feasibility Window Study of Pembrolizumab Prior to Second Evacuation for Post-molar Gestational Trophoblastic Neoplasia Pembrolizumab - Gestational Trophoblastic Disease, Gestational Trophoblastic Neoplasia | Phase 2 | Unknown | Imperial College London | 20 | 2024-02-14 | 2024-04-17 |
| Dostarlimab in Chemoresistant Gestational Trophoblastic Neoplasia Dostarlimab - Gestational Trophoblastic Neoplasia | Phase 2 | Withdrawn | University of Miami | 2023-03-01 | 2023-02-28 | |
| Camrelizumab Plus Apatinib in Patients With High-risk Gestational Trophoblastic Neoplasia Camrelizumab plus apatinib CohortA, Camrelizumab plus apatinib Cohort B - Gestational Trophoblastic Neoplasia | Phase 2 | Recruiting | Peking Union Medical College Hospital | 70 | 2022-01-27 | 2026-11-03 |
| Study of PD-1 Antibody and Bevacizumab in the Treatment of High-risk GTN After Combined Chemotherapy PD-1 inhibitor， bevacizumab - Gestational Trophoblastic Neoplasia | Phase 2 | Unknown | Women's Hospital School Of Medicine Zhejiang University | 20 | 2021-04-15 | 2022-06-03 |
| Letrozole as a Prophylaxis From GTN for Complete Mole Patients Suction evacuation, Letrozole tablets - Gestational Trophoblastic Disease | Phase 2 / Phase 3 | Unknown | Zagazig University | 200 | 2020-06-01 | 2022-07-12 |
| Phase 2 Trial for Chemo-Resistant Gestational Trophoblastic Neoplasias With Pembrolizumab (CR-GTP) Pembrolizumab Injection [Keytruda] - Gestational Trophoblastic Neoplasia | Phase 2 | Unknown | CHA University | 15 | 2020-06-01 | 2020-03-11 |
| Camrelizumab Combined With Apatinib for Recurrent Resistant GTN Apatinib, Camrelizumab - Gestational Trophoblastic Disease | Phase 2 | Completed | Peking Union Medical College Hospital | 20 | 2019-08-08 | 2021-07-30 |
| Combination of Methotrexate(MTX) and Actinomycin(ACTD) in the Low Risk Gestational Trophoblastic Neoplasma （GTN） Patients With Score of 5-6 MTX, MTX+ACTD - Gestational Trophoblastic Tumor, Effects of Chemotherapy | Phase 2 / Phase 3 | Unknown | Women's Hospital School Of Medicine Zhejiang University | 300 | 2019-03-08 | 2019-03-21 |
| Study of Hysteroscopic Repeat Curettage as the First-line Treatment in Low-risk Postmolar Gestational Trophoblastic Neoplasia Methotrexate, hysteroscopic repeat curettage - Gestational Trophoblastic Neoplasia | Phase 2 | Recruiting | Women's Hospital School Of Medicine Zhejiang University | 70 | 2019-03-01 | 2026-10-21 |
| Rescue Regimen and High Dose Methotrexate in Management of Presistent Gestational Trophoplastic Neoplasia rescue regimen, high dose methotrxate - Gestational Trophoblastic Disease | Phase 2 / Phase 3 | Unknown | Assiut University | 170 | 2017-10-01 | 2017-09-13 |
| Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Biospecimen Collection, Computed Tomography, Echocardiography Test - Acinar Cell Carcinoma, Adenoid Cystic Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 798 | 2017-01-30 | 2026-06-17 |
| Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN) TRC105, Bevacizumab - Gestational Trophoblastic Neoplasia, Choriocarcinoma | Phase 2 | Terminated | Tracon Pharmaceuticals Inc. | 3 | 2016-03-01 | 2019-07-23 |
| Surgery Plus Single Agent Chemotherapy Versus Primary Chemotherapy for Gestational Trophoblastic Neoplasms Total abdominal hysterectomy and methotrexate, Methotrexate plus folinic acid alone - Gestational Trophoblastic Neoplasms | Phase 2 / Phase 3 | Unknown | Maher elesawi kamel elesawi | 20 | 2015-09-01 | 2017-03-22 |
| Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer behavioral, psychological or informational intervention - Ovarian Sarcoma, Ovarian Stromal Cancer | Phase 2 | Completed | Ohio State University Comprehensive Cancer Center | 100 | 2010-10-01 | 2018-05-30 |
| Second Curettage in Treating Patients With Persistent Non-metastatic Gestational Trophoblastic Tumors Laboratory Biomarker Analysis, Therapeutic Conventional Surgery - Complete Hydatidiform Mole, Non-Metastatic Gestational Trophoblastic Tumor | Phase 2 | Completed | Gynecologic Oncology Group | 64 | 2007-10-09 | 2017-08-24 |
| A Trial for Patients With Gestational Trophoblastic Disease Pemetrexed - Trophoblastic Neoplasms, Uterine Neoplasms | Phase 2 | Completed | Eli Lilly and Company | 50 | 2006-07-01 | 2007-08-09 |
| Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant alemtuzumab, methylprednisolone, prednisone - Breast Cancer, Chronic Myeloproliferative Disorders | Phase 2 | Completed | Fred Hutchinson Cancer Center | 53 | 2006-07-01 | 2010-05-14 |
| Pemetrexed Disodium in Treating Patients With Recurrent or Persistent Low-Risk Gestational Trophoblastic Tumor After a Molar Pregnancy pemetrexed disodium - Gestational Trophoblastic Tumor | Phase 2 | Terminated | Gynecologic Oncology Group | 55 | 2005-07-01 | 2018-04-12 |
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Breast Neoplasms (8) · Carcinoma, Ovarian Epithelial (8) · Burkitt Lymphoma (7) · Hodgkin Disease (7) · Leukemia, Lymphocytic, Chronic, B-Cell (7) · Lymphoma (7) · Lymphoma, B-Cell, Marginal Zone (7) · Lymphoma, Follicular (7) · Lymphoma, Large B-Cell, Diffuse (7) · Lymphoma, Large-Cell, Immunoblastic (7) · Lymphoma, Mantle-Cell (7) · Lymphoma, Non-Hodgkin (7) · Neuroblastoma (7) · Ovarian Neoplasms (7)
Female Urogenital Diseases and Pregnancy Complications (27) · Neoplasms by Histologic Type (27) · Neoplasms, Germ Cell and Embryonal (27) · Pregnancy Complications (27) · Pregnancy Complications, Neoplastic (27) · Urogenital Diseases (27) · Neoplasms (26) · Trophoblastic Neoplasms (26) · Carcinoma (12) · Neoplasms, Glandular and Epithelial (12) · Neoplasms by Site (11) · Disease Attributes (10) · Female Urogenital Diseases (10) · Genital Diseases (10) · Genital Diseases, Female (10)
Methotrexate (3) · camrelizumab (3) · Alemtuzumab (2) · Dactinomycin (2) · Methylprednisolone (2) · Pemetrexed (2) · apatinib (2) · pembrolizumab (2) · Beclomethasone (1) · Bevacizumab (1) · CTLA-4 Antigen (1) · Drug Therapy (1) · ER 30346 (1) · Filgrastim (1) · Flow Cytometry (1)
Fred Hutchinson Cancer Center (4) · Gynecologic Oncology Group (3) · Peking Union Medical College Hospital (3) · Women's Hospital School Of Medicine Zhejiang University (3) · Assiut University (1) · CHA University (1) · Cancer Treatment Centers of America (1) · Case Comprehensive Cancer Center (1) · Eli Lilly and Company (1) · Hospices Civils de Lyon (1) · Imperial College London (1) · Maher elesawi kamel elesawi (1) · National Cancer Institute (NCI) (1) · National Institutes of Health Clinical Center (CC) (1) · Ohio State University Comprehensive Cancer Center (1)
United States (15) · China (6) · Egypt (2) · Canada (1) · France (1) · Guam (1) · Norway (1) · South Korea (1) · United Kingdom (1)
Allan Covens, MD (2) · Anastasios Raptis, MD (1) · Charles Theuer, MD, PhD (1) · David Hockenbery, MD (1) · David Miller, MD (1) · David S. Miller, MD (1) · Ehsan Ghorani (1) · Kristen M. Carpenter, Ph.D (1) · Leona A. Holmberg, MD, PhD (1) · Marilyn Huang, MD (1) · Mary E. D. Flowers, MD (1) · Mary Laughlin, MD (1) · Mohamed A Alabiad, MD (1) · Paul Carpenter, MD (1) · Raymond Osborne (1)
PMID 16900525, PMID 27500329, PMID 31969335, PMID 33362722, PMID 33882143, PMID 34380663, PMID 34624252, PMID 34716198, PMID 38243705, PMID 38358334, PMID 39067873, PMID 39343510, PMID 39417692, PMID 39583952, PMID 39856213, PMID 40082377, PMID 40402690, PMID 40588371, PMID 41672597, PMID 41892875, PMID 41995270, PMID 42499790
P30CA043703 (1), R21CA149675 (1), U10CA027469 (1), U10CA180868 (1), U10CA180888 (1)