32 completed, 17 unknown, 12 recruiting, 6 active not recruiting. 31 Phase 2, 13 Phase 3, 8 Not applicable, 7 Phase 1, 1 Phase 4.
Follow Pregnancy Complications, Neoplastic: new trials by email Literature Review of Pregnancy Complications, Neoplastic trials Research Report on Pregnancy Complications, Neoplastic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Uterine Artery Doppler Flow Velocimetry Parameters for Predicting the Occurrence of Persistent Gestational Trophoblastic Neoplasia After Evacuation of Complete Hydatiform Mole Gestational Trophoblastic Neoplasia, Complete Hydatiform Mole | Not yet recruiting | Minia University | 175 | 2026-01-10 | 2026-01-12 | |
| IMMUNORARE5: A National Platform of 5 Academic Phase II Trials Coordinated by Lyon University Hospital to Assess the Safety and the Efficacy of the IMMUNOtherapy With Domvanalimab + Zimberelimab Combination in Patients With Advanced RARE Cancers DOMVANALIMAB + ZIMBERELIMAB, DOMVANALIMAB + ZIMBERELIMAB + FOLFOX-4 - Peritoneal Mesothelioma, Gestational Trophoblastic Tumor | Phase 2 | Active not recruiting | Hospices Civils de Lyon | 27 | 2025-10-01 | 2026-06-25 |
| A Multi-center Cohort Study of Hydatidiform Mole in China (CN-HM-01) No intervention - Hydatidiform Mole | Recruiting | Obstetrics & Gynecology Hospital of Fudan University | 1489 | 2025-07-09 | 2025-10-02 | |
| Toripalimab Plus Actinomycin-D As Fist-Line Treatment for GTN with FIGO Score 7 Toripalimab, Actinomycin-D - Gestational Trophoblastic Neoplasia | Phase 2 | Recruiting | Peking Union Medical College Hospital | 17 | 2024-12-01 | 2024-12-31 |
| Clinical Specialty Queue For Gestational Trophoblastic Neoplasia Gestational Trophoblastic Neoplasia | Recruiting | Women's Hospital School Of Medicine Zhejiang University | 1000 | 2024-11-04 | 2024-11-12 | |
| Agnostic Therapy in Rare Solid Tumors Nivolumab - Urachal Cancer, Parathyroid Carcinoma | Phase 2 | Active not recruiting | Instituto do Cancer do Estado de São Paulo | 28 | 2024-07-16 | 2026-10-13 |
| The Psychological Impact of GTN on Women Who Have Completed Chemotherapy Treatment Gestational Trophoblastic Neoplasia | Recruiting | Sheffield Teaching Hospitals NHS Foundation Trust | 20 | 2024-05-15 | 2025-02-21 | |
| ASk Questions in GYnecologic Oncology (ASQ-GYO) Administration of the ASk Questions in GYnecologic Oncology (ASQ-GYO) Question Prompt List - Ovarian Cancer, Endometrial Cancer | Not applicable | Completed | Ira Winer | 68 | 2024-04-04 | 2026-08-20 |
| High-dose Chemotherapy as Second-line Drug Therapy for Relapsed Germ Cell Tumors High-dose chemotherapy (TI- 2 cycles, CE- 3 cycles ) - Germ Cell Tumor | Phase 2 | Recruiting | N.N. Petrov National Medical Research Center of Oncology | 25 | 2024-03-01 | 2025-08-03 |
| A Feasibility Window Study of Pembrolizumab Prior to Second Evacuation for Post-molar Gestational Trophoblastic Neoplasia Pembrolizumab - Gestational Trophoblastic Disease, Gestational Trophoblastic Neoplasia | Phase 2 | Unknown | Imperial College London | 20 | 2024-02-14 | 2024-04-17 |
| Toripalimab Plus Actinomycin-D as Fist-Line Treatment for GTN With FIGO Score 5-6 Toripalimab, Actinomycin-D - Gestational Trophoblastic Neoplasia | Not applicable | Recruiting | Peking Union Medical College Hospital | 40 | 2023-09-12 | 2025-02-06 |
| Molecular Epidemiology of Pediatric Germ Cell Tumors Questionnaire Administration, Tumor Specimen Collection, Germline DNA Samples - Germ Cell Tumor, Germinoma | Recruiting | Children's Oncology Group | 1151 | 2023-04-12 | 2025-10-24 | |
| Dostarlimab in Chemoresistant Gestational Trophoblastic Neoplasia Dostarlimab - Gestational Trophoblastic Neoplasia | Phase 2 | Withdrawn | University of Miami | 2023-03-01 | 2023-02-28 | |
| A Cohort Study of Hydatidiform Mole No intervention - Hydatidiform Mole | Not yet recruiting | Women's Hospital School Of Medicine Zhejiang University | 800 | 2022-12-01 | 2022-12-08 | |
| Camrelizumab Plus Apatinib in Patients With High-risk Gestational Trophoblastic Neoplasia Camrelizumab plus apatinib CohortA, Camrelizumab plus apatinib Cohort B - Gestational Trophoblastic Neoplasia | Phase 2 | Recruiting | Peking Union Medical College Hospital | 70 | 2022-01-27 | 2026-02-05 |
| The Accuracy of Ultrasound Diagnosis of Hydatidiform Moles Hydatidiform Mole (Diagnosis), Abortion, Spontaneous | Unknown | King's College Hospital NHS Trust | 500 | 2021-10-19 | 2024-06-11 | |
| A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT Biospecimen Collection, Carboplatin, Etoposide - Central Nervous System Nongerminomatous Germ Cell Tumor, Choriocarcinoma | Phase 2 | Recruiting | Children's Oncology Group | 160 | 2021-07-13 | 2026-09-23 |
| The Registry of Oncology Outcomes Associated With Testing and Treatment Biomarker Testing (L), Systemic Treatment (T), Patient Reported Outcomes (P) - Adenocarcinoma, Adenocystic Carcinoma | Completed | Taproot Health | 167 | 2021-05-05 | 2024-12-18 | |
| Study of PD-1 Antibody and Bevacizumab in the Treatment of High-risk GTN After Combined Chemotherapy PD-1 inhibitor， bevacizumab - Gestational Trophoblastic Neoplasia | Phase 2 | Unknown | Women's Hospital School Of Medicine Zhejiang University | 20 | 2021-04-15 | 2022-06-03 |
| Second Uterine Evacuation for Low-risk Gestational Trophoblastic Neoplasia Uterine curettage, Chemotherapy - Gestational Trophoblastic Neoplasia, Molar Pregnancy | Phase 3 | Unknown | Brigham and Women's Hospital | 150 | 2021-02-11 | 2022-05-27 |
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Gestational Trophoblastic Disease (54) · Breast Neoplasms (20) · Carcinoma, Ovarian Epithelial (19) · Ovarian Neoplasms (19) · Hydatidiform Mole (16) · Neuroblastoma (16) · Testicular Neoplasms (16) · Lymphoma (14) · Lymphoma, Non-Hodgkin (14) · Multiple Myeloma (14) · Neoplasms, Plasma Cell (14) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (14) · Testicular Germ Cell Tumor (14) · Burkitt Lymphoma (13) · Choriocarcinoma (13)
Female Urogenital Diseases and Pregnancy Complications (75) · Neoplasms by Histologic Type (75) · Urogenital Diseases (75) · Pregnancy Complications (74) · Neoplasms, Germ Cell and Embryonal (72) · Trophoblastic Neoplasms (69) · Neoplasms (68) · Neoplasms, Glandular and Epithelial (38) · Carcinoma (36) · Neoplasms by Site (30) · Female Urogenital Diseases (29) · Genital Diseases (29) · Urogenital Neoplasms (29) · Endocrine System Diseases (28)
Methotrexate (9) · Dactinomycin (8) · Drug Therapy (5) · Carboplatin (4) · Etoposide (4) · Vacuum Curettage (4) · Filgrastim (3) · Flow Cytometry (3) · Granulocyte Colony-Stimulating Factor (3) · Ifosfamide (3) · Leucovorin (3) · camrelizumab (3) · Alemtuzumab (2) · Bevacizumab (2) · Cisplatin (2)
Gynecologic Oncology Group (6) · Women's Hospital School Of Medicine Zhejiang University (6) · Fred Hutchinson Cancer Center (5) · Peking Union Medical College Hospital (4) · Children's Oncology Group (3) · Hospices Civils de Lyon (3) · National Taiwan University Hospital (2) · OHSU Knight Cancer Institute (2) · Ohio State University Comprehensive Cancer Center (2) · Tracon Pharmaceuticals Inc. (2) · Vanderbilt-Ingram Cancer Center (2) · Abramson Cancer Center at Penn Medicine (1) · Alliance for Clinical Trials in Oncology (1) · Assiut University (1) · AstraZeneca (1)
United States (40) · China (14) · United Kingdom (5) · France (4) · Australia (3) · Canada (3) · Brazil (2) · Egypt (2) · Germany (2) · Italy (2) · South Korea (2) · Taiwan (2) · Belgium (1) · Denmark (1) · Guam (1)
Allan Covens, MD (2) · Joseph Bubalo, PharmD, BCPS, BCOP (2) · Raymond Osborne (2) · Agnes L. Soriano-Estrella, MD (1) · Aleksei M Belyaev, MD,DSc,Prof. (1) · Anastasios Raptis, MD (1) · Antonio Braga, MD, PhD (1) · Barbara Andersen, PhD (1) · Brian Engelhardt, MD (1) · Camila MV Moniz, Doctor (1) · Charles Theuer, MD (1) · Charles Theuer, MD, PhD (1) · Daniel H. Sterman, MD (1) · Darren Feldman, MD (1) · David Hockenbery, MD (1)
PMID 11677152, PMID 13129680, PMID 14550593, PMID 15814645, PMID 15979551, PMID 16900525, PMID 18039680, PMID 20068553, PMID 22503395, PMID 24105472, PMID 24105752, PMID 27500329, PMID 29149611, PMID 30563754, PMID 31969335, PMID 32460997, PMID 33362722, PMID 33882143, PMID 34380663, PMID 34624252, PMID 34716198, PMID 37612621, PMID 38243705, PMID 38358334, PMID 39028926, PMID 39067873, PMID 39343510, PMID 39417692, PMID 39583952, PMID 39856213, PMID 40082377, PMID 40382972, PMID 40402690, PMID 40543844, PMID 40588371, PMID 41672597, PMID 41892875, PMID 41995270, PMID 42499790
U10CA027469 (3), U10CA180868 (3), P30CA068485 (2), P30CA069533 (2), P30CA014520 (1), P30CA016087 (1), P30CA022453 (1), P30CA043703 (1), R21CA135005 (1), R21CA149675 (1), U01CA076642 (1), U10CA180821 (1), U10CA180886 (1), U10CA180888 (1)