31 completed, 20 recruiting, 11 unknown, 7 active not recruiting. 44 Not applicable, 9 Phase 4, 3 Phase 3, 2 Phase 2, 1 Phase 1.
Follow Gestational Hypertension: new trials by email Literature Review of Gestational Hypertension trials Research Report on Gestational Hypertension
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vagal Stimulation Therapy and Preeclampsia Vagal stimulation physiotherapy with trigger point release, Positional Release Therapy - Gestational Hypertension, Preeclampsia | Not applicable | Recruiting | Fundación Internacional René Mey | 210 | 2026-10-15 | 2026-09-02 |
| MH-Rx Study (Baby on Board: Check-in on You, Your Medication, & Your Blood Pressure) Community Health Worker (CHW)/Social Worker (SW)-led non-medical health related needs (NMHRN) intervention + Clinician-Led Medication Therapy Management (MTM) with remote blood pressure monitoring, Active Comparator (Control group) - Hypertensive Disorders of Pregnancy, Chronic Hypertension in Pregnancy | Not applicable | Recruiting | Texas Southern University | 158 | 2026-09-25 | 2026-10-14 |
| Exploring the Effect of Discharge Education, Blood Pressure Cuffs, and Postpartum Bracelets to Improve Health Among Newly Diagnosed Gestational Hypertension and Preeclampsia Patients During the Postpartum Period. Education, Blood Pressure Cuff, and Visual Cue Bracelet - Preeclampsia, Gestational Hypertension | Not applicable | Not yet recruiting | Memorial Hermann Health System | 40 | 2026-09-16 | 2026-09-08 |
| Nutrition Optimization and Community Upliftment for Postpartum Recovery: Hypertension MFeast ENHANCED, MFeast Usual Care - Obesity, Maternal, Pre-Eclampsia; Complicating Pregnancy | Not applicable | Withdrawn | Johns Hopkins University | 2026-09-01 | 2025-10-10 | |
| Community Health Worker Support to Lower Blood Pressure After a Pregnancy With High Blood Pressure Alabama Womb to Heart Solution (AW2H) Community Health Worker (CHW) Program, Usual postpartum care with self-measured blood pressure education and home blood pressure monitor - Pregnancy-Associated Hypertension, Gestational Hypertension | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 174 | 2026-08-31 | 2026-08-24 |
| Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Pregnant Women With Hypertensive Disorders of Pregnancy Hypertensive Disorder of Pregnancy, Gestational Hypertension | Recruiting | Josip Juraj Strossmayer University of Osijek | 80 | 2026-04-01 | 2026-07-27 | |
| Cardiovascular Protection After Preeclampsia With Enalapril Enalapril, Standard treatment - Preeclampsia, Hypertensive Disorder of Pregnancy | Phase 3 | Recruiting | Women and Infants Hospital of Rhode Island | 60 | 2026-01-01 | 2026-08-06 |
| Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories spironolactone 25 mg orally once daily, Placebo tablet to match spironolactone - Preeclampsia, Gestational Hypertension | Phase 2 | Recruiting | Massachusetts General Hospital | 204 | 2025-10-16 | 2026-04-03 |
| Evaluation of sFlt-1/PlGF Ratio ,OPG and sEng as Predictive Biomarkers in the Diagnosis and Treatment Evaluation of Preeclampsia Preeclampsia, Gestational Hypertension | Recruiting | Ammar Jassim Abed | 120 | 2025-10-10 | 2026-01-20 | |
| AtorvaStatin Postpartum and Reduction of Cardiovascular risK Atorvastatin 10 mg, Placebo - Hypertensive Disorders of Pregnancy, Preeclampsia | Phase 4 | Recruiting | Ohio State University | 76 | 2025-10-03 | 2025-10-20 |
| Delivering HOPE (Helping Women Optimize Prenatal Equity) Enhanced Standard of Care (ESoC), Delivering HOPE - Gestational Weight Gain, Diet, Healthy | Not applicable | Recruiting | University of Arkansas | 1440 | 2025-06-24 | 2026-06-26 |
| Postpartum CO Rehabilitation Postpartum Cardio-obstetric Rehabilitation Program - Gestational Hypertension, Preeclampsia (PE) | Not applicable | Not yet recruiting | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 40 | 2025-06-15 | 2025-05-14 |
| Moms@Home: A Storytelling-based Mobile Health Intervention to Improve Blood Pressure Management in Pregnancy Moms@Home, Enhanced Standard of Care - Hypertension in Pregnancy, Chronic Hypertension | Not applicable | Recruiting | University of Massachusetts, Worcester | 100 | 2025-05-16 | 2026-06-16 |
| Remote Postpartum Blood Pressure Monitoring and Cardiovascular Education Video, Text Reminder, Blood pressure threshold - Pre-Eclampsia; Complicating Pregnancy, Gestational Hypertension | Not applicable | Recruiting | Ochsner Health System | 296 | 2025-03-17 | 2025-04-09 |
| A Randomized, Placebo-controlled Trial of DAPAgliflozin (DAPA) for Cardiovascular Risk Reduction in the Postpartum Period of Hypertensive Pregnancies (HP) Placebo, Dapagliflozin 10mg Tab - Gestational Hypertension, Hypertension in Pregnancy | Phase 4 | Recruiting | University of Michigan | 200 | 2025-03-02 | 2026-03-04 |
| Mobile Health Interventions to Prevent Heart Disease After Hypertensive Disorders of Pregnancy Digital Blood Pressure Monitoring System, Mobile health application - Hypertension in Pregnancy, Pre-Eclampsia | Not applicable | Active not recruiting | Northwestern University | 120 | 2024-11-07 | 2026-06-08 |
| Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL Aspirin 81 mg, Aspirin 162 mg - Hypertensive Disorders of Pregnancy, Preeclampsia | Phase 4 | Recruiting | Ohio State University | 10742 | 2024-10-18 | 2026-05-04 |
| Effect of Pilates Exercise Versus Circuit Exercise Training on Gestational Hypertension Anti-hypertensive drug (Methyldopa 250 mg), Pilates exercise, Circuit exercise training - Gestational Hypertension | Not applicable | Completed | Cairo University | 69 | 2024-09-30 | 2025-12-19 |
| Brain Health in Midlife A combination of various tests and biomarkers will be completed to understand the effect of hypertensive disorders of pregnancy on brain health in midlife. - Brain Health, Gestational Hypertension | Completed | University of Kansas Medical Center | 24 | 2024-09-23 | 2026-07-14 | |
| Intervention for Fear of Childbirth in High-Risk Pregnant Women Art therapy group, Control group - Threatened Premature Birth, Premature Membrane Rupture | Not applicable | Completed | Kocaeli University | 149 | 2024-09-16 | 2026-01-06 |
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Hypertension, Pregnancy-Induced (80) · Pre-Eclampsia (55) · Diabetes, Gestational (19) · Hypertension (14) · Pregnancy Complications (13) · Eclampsia (11) · Premature Birth (11) · Toxemia (11) · Cardiovascular Diseases (7) · Obesity (7) · HELLP Syndrome (4) · Anemia (3) · Fetal Growth Retardation (3) · Overweight (3) · Vascular Diseases (3)
Female Urogenital Diseases and Pregnancy Complications (80) · Urogenital Diseases (80) · Vascular Diseases (77) · Cardiovascular Diseases (73) · Pregnancy Complications (67) · Hypertension (66) · Nutritional and Metabolic Diseases (23) · Endocrine System Diseases (19) · Glucose Metabolism Disorders (19) · Metabolic Diseases (19) · Diabetes Mellitus (17) · Pathological Conditions, Signs and Symptoms (16) · Obstetric Labor Complications (12) · Signs and Symptoms (12) · Body Weight (11)
Aspirin (3) · Control Groups (3) · Community Health Workers (2) · Enalapril (2) · Anti-Inflammatory Agents, Non-Steroidal (1) · Antihypertensive Agents (1) · Atorvastatin (1) · Blood Pressure Determination (1) · Blood Pressure Monitoring, Ambulatory (1) · Cholecalciferol (1) · Circuit-Based Exercise (1) · Citrulline (1) · Educational Status (1) · Exercise (1) · Exercise Movement Techniques (1)
Massachusetts General Hospital (3) · Alisse Hauspurg (2) · Cedars-Sinai Medical Center (2) · Hasselt University (2) · Ohio State University (2) · Peking University (2) · The University of Texas Medical Branch, Galveston (2) · University of Alabama at Birmingham (2) · University of Colorado, Denver (2) · University of Oxford (2) · University of Pennsylvania (2) · University of Pittsburgh (2) · Westlake University (2) · Women and Infants Hospital of Rhode Island (2) · Abant Izzet Baysal University (1)
United States (40) · China (7) · Turkey (Türkiye) (5) · United Kingdom (5) · Canada (3) · Belgium (2) · Brazil (2) · Egypt (2) · India (2) · Italy (2) · Argentina (1) · Australia (1) · Austria (1) · Chile (1) · Colombia (1)
Alisse Hauspurg, MD (3) · Alisse K Hauspurg, MD (2) · Haijun Wang, Ph.D (2) · Abeer Mohamed Eldeeb, PhD (1) · Adam Lewkowitz, MD, MPHS (1) · Amal Al Hajje, PhD in Clinical Pharmacy (1) · Amy A Sarma, MD (1) · Ana Stupin, MD, PhD (1) · Ananth Karumanchi, MD (1) · Anna Palatnik, MD (1) · Anne Cathrine Staff, MD, PhD (1) · Ashley Hesson, MD, PhD (1) · Benjamin Bush, M.D. (1)
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K12AR086524 (1), K23HL159331 (1), K23HL163450 (1), K23HL168356 (1), P30AG072973 (1), R01MD017083 (1), UL1TR001082 (1)