5 completed, 5 recruiting, 3 active not recruiting, 3 unknown. 18 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 18 | Completed 5, Recruiting 5, Active not recruiting 3, Unknown 3, Terminated 2 |
| Phase 2 | 4 | Unknown 3, Recruiting 1 |
Follow Germ Cell Tumor: new trials by email Literature Review of Germ Cell Tumor trials Research Report on Germ Cell Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Maintenance Zanzalintinib With Etoposide After HDCT in GCT Zanzalintinib, Etoposide Capsule - Germ Cell Tumor | Phase 1 / Phase 2 | Recruiting | Indiana University | 38 | 2025-11-12 | 2025-11-21 |
| A Study of ZW251 in Participants With Advanced Solid Tumors ZW251 - Hepatocellular Carcinoma, Squamous Cell Non-Small Cell Lung Cancer | Phase 1 | Recruiting | Zymeworks BC Inc. | 140 | 2025-10-21 | 2026-10-05 |
| Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors XmAb541 - Ovarian Cancer, Endometrial Cancer | Phase 1 | Recruiting | Xencor, Inc. | 282 | 2024-04-04 | 2026-10-09 |
| A Study of DS-9606a in Patients With Advanced Solid Tumors DS-9606a - Advanced Cancer, Metastatic Cancer | Phase 1 | Terminated | Daiichi Sankyo | 88 | 2022-05-31 | 2026-03-20 |
| B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults second generation 4-1BBζ B7H3-EGFRt-DHFR, second generation 4-1BBζ B7H3-EGFRt-DHFR(selected) and a second generation 4-1BBζ CD19-Her2tG, Pembrolizumab - Pediatric Solid Tumor, Germ Cell Tumor | Phase 1 | Active not recruiting | Seattle Children's Hospital | 68 | 2020-07-13 | 2026-04-28 |
| Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors SCRI-CARB7H3(s); B7H3-specific chimeric antigen receptor (CAR) T cel - Central Nervous System Tumor, Diffuse Intrinsic Pontine Glioma | Phase 1 | Recruiting | Seattle Children's Hospital | 90 | 2019-12-11 | 2026-04-13 |
| EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults second generation 4-1BBζ EGFR806-EGFRt, second generation 4-1BBζ EGFR806-EGFRt and a second generation 4 1BBζ CD19-Her2tG - Pediatric Solid Tumor, Germ Cell Tumor | Phase 1 | Active not recruiting | Seattle Children's Hospital | 44 | 2019-06-18 | 2026-10-08 |
| EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors EGFR806-specific chimeric antigen receptor (CAR) T cell - Central Nervous System Tumor, Pediatric, Glioma | Phase 1 | Completed | Seattle Children's Hospital | 11 | 2019-03-19 | 2025-12-17 |
| HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors HER2-specific chimeric antigen receptor (CAR) T cell - Central Nervous System Tumor, Pediatric, Glioma | Phase 1 | Active not recruiting | Seattle Children's Hospital | 10 | 2018-07-26 | 2025-12-17 |
| Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies Vorinostat - Ewing Sarcoma, Rhabdomyosarcoma | Phase 1 | Recruiting | New York Medical College | 30 | 2017-03-17 | 2026-04-15 |
| Study of the Hypomethylating Drug Guadecitabine (SGI-110) Plus Cisplatin in Relapsed Refractory Germ Cell Tumors Guadecitabine (SGI-110) - Germ Cell Tumor, Testis Cancer | Phase 1 | Completed | Nasser Hanna | 14 | 2015-04-27 | 2020-09-23 |
| MR-guided High Intensity Focused Ultrasound (HIFU) on Pediatric Solid Tumors Magnetic Resonance High Intensity Focused Ultrasound - Relapsed Pediatric Solid Tumors, Refractory Pediatric Solid Tumors | Phase 1 | Completed | AeRang Kim | 7 | 2014-04-01 | 2025-01-01 |
| A Study of CD45RA+ Depleted Haploidentical Stem Cell Transplantation in Children With Relapsed or Refractory Solid Tumors and Lymphomas alemtuzumab, fludarabine, sirolimus - Ewing Sarcoma, Gastrointestinal Tumor | Phase 1 | Completed | St. Jude Children's Research Hospital | 23 | 2012-08-20 | 2026-02-06 |
| Salvage Chemotherapy for Poor Prognosis Germ Cell Tumors Bevacizumab, ICE chemotherapy regimen - Germ Cell Tumor | Phase 1 / Phase 2 | Unknown | Assistance Publique - Hôpitaux de Paris | 30 | 2012-04-01 | 2019-02-19 |
| Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors sirolimus - Ewing's Sarcoma, Osteosarcoma | Phase 1 | Completed | Emory University | 18 | 2011-04-01 | 2020-05-29 |
| Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Carboplatin, Mannitol, Melphalan - Central Nervous System Embryonal Neoplasm, Embryonal Tumor With Multilayered Rosettes, C19MC-Altered | Phase 1 / Phase 2 | Unknown | OHSU Knight Cancer Institute | 17 | 2009-07-09 | 2021-10-26 |
| CpG 7909 in Treating Patients Who Have Undergone Autologous Stem Cell Transplant keyhole limpet hemocyanin, tetanus toxoid - Germ Cell Tumor, Leukemia | Phase 1 | Terminated | Masonic Cancer Center, University of Minnesota | 19 | 2003-09-01 | 2017-11-29 |
| Tandem Peripheral Blood Stem Cell (PBSC) Rescue for High Risk Solid Tumors High-Dose Chemotherapy with Tandem PBSC Rescue. - Ewing's Sarcoma, Soft Tissue Sarcoma | Phase 1 / Phase 2 | Unknown | Ann & Robert H Lurie Children's Hospital of Chicago | 12 | 1999-04-01 | 2010-10-11 |
Neoplasms, Germ Cell and Embryonal (18) · Rhabdoid Tumor (7) · Sarcoma, Ewing (7) · Wilms Tumor (7) · Neuroblastoma (6) · Rhabdomyosarcoma (6) · Hepatoblastoma (5) · Medulloblastoma (5) · Ependymoma (4) · Glioma (4) · Neuroectodermal Tumors, Primitive (4) · Osteosarcoma (4) · Brain Neoplasms (3) · Carcinoma, Hepatocellular (3) · Central Nervous System Neoplasms (3)
Neoplasms (18) · Neoplasms by Histologic Type (18) · Neoplasms by Site (13) · Neoplasms, Glandular and Epithelial (11) · Neoplasms, Complex and Mixed (10) · Neoplasms, Nerve Tissue (10) · Neoplasms, Neuroepithelial (10) · Neuroectodermal Tumors (10) · Male Urogenital Diseases (9) · Urogenital Diseases (9) · Urogenital Neoplasms (9) · Female Urogenital Diseases (8) · Female Urogenital Diseases and Pregnancy Complications (8) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (7) · Genetic Diseases, Inborn (7)
Automobiles (3) · Melphalan (2) · Sirolimus (2) · Alemtuzumab (1) · Bevacizumab (1) · Busulfan (1) · Carboplatin (1) · Cyclophosphamide (1) · Drug Therapy (1) · Etoposide (1) · ICE protocol 5 (1) · Mannitol (1) · Stem Cell Transplantation (1) · Tetanus Toxoid (1) · Vorinostat (1)
Seattle Children's Hospital (5) · AeRang Kim (1) · Ann & Robert H Lurie Children's Hospital of Chicago (1) · Assistance Publique - Hôpitaux de Paris (1) · Daiichi Sankyo (1) · Emory University (1) · Indiana University (1) · Masonic Cancer Center, University of Minnesota (1) · Nasser Hanna (1) · New York Medical College (1) · OHSU Knight Cancer Institute (1) · St. Jude Children's Research Hospital (1) · Xencor, Inc. (1) · Zymeworks BC Inc. (1)
United States (17) · France (2) · Spain (2) · United Kingdom (2) · Belgium (1) · Denmark (1) · Ireland (1) · Japan (1) · Portugal (1) · Taiwan (1)
Rebecca Ronsley, MD (2) · AeRang Kim, MD, PhD (1) · Brando Triplett, MD (1) · Catherine Albert, MD (1) · Edward A Neuwelt (1) · Jennifer King, MD (1) · Jeremy Rosenblum, MD (1) · Juliane Gust, MD, PhD (1) · Katie Albert, MD (1) · Maggie Weinstein, MD, PhD, MPH (1) · Marcie Tomblyn, MD, MS (1) · Morris Kletzel, M.D. (1) · Muna Qayed, MD (1) · Nasser Hanna, MD (1)
PMID 31401903, PMID 31876107, PMID 34253928, PMID 35468680, PMID 37640679, PMID 39255444, PMID 39775044, PMID 41798119
2025 (1), R01NS044687 (1)