20 recruiting, 17 completed, 8 active not recruiting, 8 unknown. 25 Phase 2, 18 Phase 1, 7 Not applicable, 5 Phase 3, 1 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tumor-Lymph Node Mapping ICG (Indocyanine Green) - Pediatric Solid Tumors, Rhabdomyosarcoma | Not yet recruiting | University of Rochester | 10 | 2026-12-13 | 2026-08-26 | |
| Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors Methionine-Reduced Diet - Adenocarcinoma, Basal Cell Carcinoma | Early Phase 1 | Recruiting | University of California, Irvine | 25 | 2026-05-01 | 2026-07-31 |
| Maintenance Zanzalintinib With Etoposide After HDCT in GCT Zanzalintinib, Etoposide Capsule - Germ Cell Tumor | Phase 1 / Phase 2 | Recruiting | Indiana University | 38 | 2025-11-12 | 2025-11-21 |
| A Study of ZW251 in Participants With Advanced Solid Tumors ZW251 - Hepatocellular Carcinoma, Squamous Cell Non-Small Cell Lung Cancer | Phase 1 | Recruiting | Zymeworks BC Inc. | 140 | 2025-10-21 | 2026-10-05 |
| A Single-arm, Phase II Clinical Trial of ASPIRin to prEvent Venous Thromboembolism in Patients With Advanced Germ Cell Tumors Receiving Chemotherapy Low-dose ASA - Germ Cell Tumor, Testicular Cancer | Phase 2 | Recruiting | Wake Forest University Health Sciences | 35 | 2025-08-28 | 2026-07-24 |
| Treatment of Newly Diagnosed Central Malignant Germ Cell Tumor People With Teniposide Injection Combined With Cisplatin. Teniposide Injection - GCT, Germ Cell Tumor | Phase 2 | Recruiting | Chengcheng Guo | 40 | 2024-08-13 | 2025-09-23 |
| Effect and Safety of Ocoxin Oral Solution on the Quality of Life of Paediatric Patients With Advanced Stage Solid Tumours Ocoxin Oral solution - Advanced Cancer, Advanced Solid Tumor | Not applicable | Unknown | Catalysis SL | 40 | 2024-04-28 | 2024-04-12 |
| SerUm and Plasma MicroRNAs in Malignant Ovarian gERm Cell Tumours Blood test, Pathology specimen miRNA expression - Germ Cell Ovarian Cancer, Germ Cell Tumor | Not yet recruiting | Imperial College London | 24 | 2024-04-14 | 2024-03-26 | |
| Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors XmAb541 - Ovarian Cancer, Endometrial Cancer | Phase 1 | Recruiting | Xencor, Inc. | 282 | 2024-04-04 | 2026-10-09 |
| High-dose Chemotherapy as Second-line Drug Therapy for Relapsed Germ Cell Tumors High-dose chemotherapy (TI- 2 cycles, CE- 3 cycles ) - Germ Cell Tumor | Phase 2 | Recruiting | N.N. Petrov National Medical Research Center of Oncology | 25 | 2024-03-01 | 2025-08-03 |
| Thromboprophylaxis in Good and Intermediate Prognosis Advanced Germ Cell Tumors Thromboprophylaxis - Germ Cell Tumor | Phase 3 | Recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 387 | 2023-10-17 | 2025-06-15 |
| Robot-assisted ICG-guided Sentinel Node Biopsy in Testicular Cancer Robot-assisted ICG-guided sentinel lymph node biopsy - Germ Cell Tumor, Seminoma | Not applicable | Recruiting | Heinrich-Heine University, Duesseldorf | 44 | 2023-09-06 | 2025-09-15 |
| Morbidity, Long-term Side Effects and Quality of Life in Germ-cell Tumor Long Survivors Treated with High-dose Chemotherapy and Autologous Stem Cell Transplant quality of life questionnaire - Germ Cell Tumor | Not applicable | Recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 180 | 2023-05-31 | 2024-10-18 |
| Molecular Epidemiology of Pediatric Germ Cell Tumors Questionnaire Administration, Tumor Specimen Collection, Germline DNA Samples - Germ Cell Tumor, Germinoma | Recruiting | Children's Oncology Group | 1151 | 2023-04-12 | 2025-10-24 | |
| Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification Observational - Glioma, Glioneuronal Tumor | Recruiting | European Organisation for Research and Treatment of Cancer - EORTC | 1650 | 2023-03-21 | 2025-12-17 | |
| Genetic and Molecular Risk Profiles of Pediatric Malignant Brain Tumors in China Medulloblastoma, Central Nervous System Tumor, Pediatric | Recruiting | Beijing Tiantan Hospital | 400 | 2023-01-01 | 2023-01-05 | |
| CD30 CAR for CD30+ NSGCT ATLCAR.CD30 Cells, Cyclophosphamid, Fludarabine - Germ Cell Tumor, Nonseminomatous Germ Cell Tumor | Phase 2 | Completed | UNC Lineberger Comprehensive Cancer Center | 2 | 2022-12-09 | 2026-07-07 |
| A Pilot Study of Thermodox and MR-HIFU for Treatment of Relapsed Solid Tumors Magnetic Resonance-Guided High Intensity Focused Ultrasound, Lyso-thermosensitive Liposomal Doxorubicin - Solid Tumors, Soft Tissue Sarcoma | Phase 2 | Withdrawn | Children's National Research Institute | 2022-11-10 | 2025-01-01 | |
| Multidisciplinary Approach to Fatigue Ergospirometry - Breast Cancer, Germ Cell Tumor | Not applicable | Terminated | Jules Bordet Institute | 12 | 2022-08-19 | 2026-10-26 |
| A Study of DS-9606a in Patients With Advanced Solid Tumors DS-9606a - Advanced Cancer, Metastatic Cancer | Phase 1 | Terminated | Daiichi Sankyo | 88 | 2022-05-31 | 2026-03-20 |
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Neoplasms, Germ Cell and Embryonal (64) · Rhabdomyosarcoma (11) · Sarcoma (11) · Sarcoma, Ewing (11) · Wilms Tumor (10) · Lymphoma (9) · Neuroblastoma (9) · Rhabdoid Tumor (8) · Brain Neoplasms (7) · Endodermal Sinus Tumor (7) · Ependymoma (7) · Glioma (7) · Medulloblastoma (7) · Neoplasms (7) · Nonseminomatous germ cell tumor (7)
Neoplasms by Histologic Type (64) · Neoplasms (57) · Neoplasms by Site (32) · Neoplasms, Glandular and Epithelial (22) · Urogenital Diseases (21) · Neoplasms, Nerve Tissue (19) · Neuroectodermal Tumors (19) · Urogenital Neoplasms (18) · Male Urogenital Diseases (17) · Neoplasms, Neuroepithelial (17) · Female Urogenital Diseases and Pregnancy Complications (15) · Neoplasms, Connective and Soft Tissue (15) · Neoplasms, Complex and Mixed (14) · Female Urogenital Diseases (12) · Hemic and Lymphatic Diseases (12)
Cisplatin (7) · Etoposide (5) · Automobiles (3) · Carboplatin (3) · Drug Therapy (3) · Ifosfamide (3) · Bevacizumab (2) · Bleomycin (2) · Cyclophosphamide (2) · Granulocyte Colony-Stimulating Factor (2) · Melphalan (2) · Paclitaxel (2) · Sirolimus (2) · durvalumab (2) · etoposide phosphate (2)
Seattle Children's Hospital (6) · Children's Oncology Group (3) · Gustave Roussy, Cancer Campus, Grand Paris (3) · National Cancer Institute, Slovakia (3) · Indiana University (2) · Masonic Cancer Center, University of Minnesota (2) · Memorial Sloan Kettering Cancer Center (2) · Shandong First Medical University (2) · St. Jude Children's Research Hospital (2) · AeRang Kim (1) · Alliance for Clinical Trials in Oncology (1) · Ann & Robert H Lurie Children's Hospital of Chicago (1) · Assistance Publique - Hôpitaux de Paris (1) · Beijing Tiantan Hospital (1) · Catalysis SL (1)
United States (40) · France (9) · China (6) · United Kingdom (6) · Belgium (4) · Spain (4) · Australia (3) · Canada (3) · Germany (3) · Italy (3) · Slovakia (3) · Denmark (2) · Ireland (2) · Japan (2) · Netherlands (2)
AeRang Kim, MD, PhD (2) · Darren Feldman, MD (2) · Jennifer King, MD (2) · Jingfu Wang, MD (2) · Rebecca Ronsley, MD (2) · A. L Frazier (1) · Abby R Rosenberg, MD, MS (1) · Aleksei M Belyaev, MD,DSc,Prof. (1) · Alexandre Chan, Pharm D (1) · Brando Triplett, MD (1) · Caroline S Dorfman (1) · Catherine Albert, MD (1) · Charles P Reynolds (1) · Costantine Albany, MD (1)
PMID 24595454, PMID 30157803, PMID 30243800, PMID 30563754, PMID 31037789, PMID 31401903, PMID 31680625, PMID 31876107, PMID 33960833, PMID 34253928, PMID 34817581, PMID 35468680, PMID 36178972, PMID 36221816, PMID 36737276, PMID 37640679, PMID 37783480, PMID 38851732, PMID 39028926, PMID 39255444, PMID 39775044, PMID 40597835, PMID 41382138, PMID 41798119, PMID 41823372, PMID 42304319
2025 (1), K08CA245107 (1), R01NS044687 (1), R21CA218625 (1), U10CA098543 (1), U10CA180821 (1), U10CA180886 (1), UG1CA189974 (1)