6 completed, 2 terminated, 1 not yet recruiting, 1 recruiting. 4 Phase 3, 3 Phase 2, 2 Not applicable, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 4 | Completed 2, Recruiting 1, Terminated 1 |
| Phase 2 | 3 | Completed 2, Not yet recruiting 1 |
| Not applicable | 2 | Completed 1, Terminated 1 |
| Phase 1 | 1 | Completed 1 |
Follow Fungal Keratitis: new trials by email Literature Review of Fungal Keratitis trials Research Report on Fungal Keratitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trial to Evaluate the Efficacy And Safety of IVIEW-1201 In the Treatment of Fungal Keratitis IVIEW-1201, NATACYN® - Fungal Keratitis | Phase 2 | Not yet recruiting | IVIEW Therapeutics Inc. | 60 | 2026-08-01 | 2025-10-15 |
| Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A Cyclosporine A, Placebo Comparator: Placebo - Fungal Keratitis, Corneal Ulcer | Phase 3 | Recruiting | University of California, San Francisco | 150 | 2025-09-01 | 2026-06-05 |
| Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction Moxifloxacin Ophthalmic, Chlorhexidine Gluconate, Natamycin - Acanthamoeba Keratitis, Fungal Keratitis | Phase 3 | Completed | University of California, San Francisco | 330 | 2022-08-03 | 2026-09-03 |
| Intrastromal Injection of Fluconazole in Treatment of Fungal Keratitis Topical fluconazole eye drops, Intrastromal injection of fluconazole - Safety, Efficacy | Not applicable | Completed | Tanta University | 40 | 2022-01-01 | 2026-04-30 |
| The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study Moxifloxacin Ophthalmic 0.5% Ophthalmic Solution, Ceftazidime 5% + vancomycin 5%, Gentamicin 1.4% + vancomycin 5% - Bacterial Keratitis, Fungal Keratitis | Completed | Alexandria University | 123 | 2021-12-31 | 2024-01-25 | |
| Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers Intrastromal voriconazole, Natamycin - Corneal Ulcer, Fungal Keratitis | Phase 3 | Completed | University of California, San Francisco | 70 | 2016-09-01 | 2025-09-25 |
| Safety and Efficacity of Corneal Collagen Crosslinking in Infectious Keratitis (Bacterial and Fungal ): Randomized,Controlled, Prospective Study. (CXL) Crosslinking, antibiotic treatment - Bacterial Keratitis, Fungal Keratitis | Not applicable | Terminated | Nantes University Hospital | 21 | 2014-09-01 | 2017-06-01 |
| Collagen Cross-linking in Infectious Keratitis Trial Collagen cross-linking - Infectious Keratitis, Bacterial Keratitis | Phase 2 | Completed | Chulalongkorn University | 30 | 2013-03-01 | 2015-05-04 |
| A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine povidone-iodine 1.25% ophthalmic solution, natamycin ophthalmic suspension, USP 5% - Fungal Keratitis | Phase 3 | Terminated | University of California, Los Angeles | 78 | 2008-03-01 | 2014-12-04 |
| Therapeutic Exploratory Study of Comparing Natamycin and Voriconazole to Treat Fungal Corneal Ulcer Natamycin 5%, Voriconazole, Corneal de-epithelialization - Fungal Keratitis | Phase 1 / Phase 2 | Completed | University of California, San Francisco | 120 | 2007-11-01 | 2018-08-07 |
Corneal Ulcer (3) · Keratitis (3) · Acanthamoeba Keratitis (1) · Corneal Diseases (1) · Eye Infections, Fungal (1) · Hypersensitivity (1) · Ulcer (1)
Eye Diseases (5) · Eye Infections (5) · Infections (5) · Corneal Diseases (4) · Keratitis (2) · Amebiasis (1) · Bacterial Infections and Mycoses (1) · Eye Infections, Parasitic (1) · Immune System Diseases (1) · Mycoses (1) · Parasitic Diseases (1) · Pathologic Processes (1) · Pathological Conditions, Signs and Symptoms (1) · Protozoan Infections (1)
Natamycin (4) · Ophthalmic Solutions (2) · Voriconazole (2) · Ceftazidime (1) · Chromatin Immunoprecipitation Sequencing (1) · Corneal Cross-Linking (1) · Cyclosporine (1) · Gentamicins (1) · Moxifloxacin (1) · Povidone-Iodine (1) · Rose Bengal (1) · chlorhexidine gluconate (1)
University of California, San Francisco (4) · Alexandria University (1) · Chulalongkorn University (1) · IVIEW Therapeutics Inc. (1) · Nantes University Hospital (1) · Tanta University (1) · University of California, Los Angeles (1)
India (4) · Egypt (2) · United States (2) · Brazil (1) · France (1) · Thailand (1)
Jennifer Rose-Nussbaumer, MD (2) · Amira A Nayel, PharmD (1) · Gerami D Seitzman, MD (1) · N V Prajna, MD (1) · Nelly M Mohamed, PhD (1) · Nicole Varnado, MPH (1) · Nisha Acharya, MD MS (1) · Noha A Hamdy, PhD (1) · Sherwin J. Isenberg, M.D. (1) · Tamer H Massoud, PhD (1) · Thomas M Lietman, MD (1) · Tom Lietman, MD (1)
PMID 32557558, PMID 20547942, PMID 39011096, PMID 39192339, PMID 41561665, PMID 42348235
UG1EY028518 (1)