3 active not recruiting, 2 completed, 2 recruiting, 2 terminated. 7 Phase 1, 2 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Active not recruiting 3, Completed 2, Recruiting 1, Terminated 1 |
| Phase 2 | 2 | Active not recruiting 1, Terminated 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow radiprodil: new trials by email Literature Review of radiprodil trials Research Report on radiprodil
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Effect of Carbamazepine or Itraconazole on Radiprodil in Healthy Adult Participants Radiprodil, Carbamazepine, Itraconazole (200 mg) - Healthy Adult Participants | Phase 1 | Active not recruiting | GRIN Therapeutics, Inc. | 36 | 2026-06-08 | 2026-10-21 |
| Radiprodil in Participants With Hepatic Impairment Radiprodil - Hepatic Impairment | Phase 1 | Recruiting | GRIN Therapeutics, Inc. | 40 | 2026-03-03 | 2026-05-08 |
| Beeline: A Phase 3 Study in GRIN-related Neurodevelopmental Disorder Radiprodil, Placebo - GRIN-related Neurodevelopmental Disorder | Phase 3 | Recruiting | GRIN Therapeutics, Inc. | 100 | 2026-01-05 | 2026-07-17 |
| Phase 1, Open-label, Drug-drug Interaction Study to Assess Effect Between Radiprodil and the Co-administered Drugs. Radiprodil + co-administered drugs - Tuberous Sclerosis Complex (TSC), Focal Cortical Dysplasia | Phase 1 | Completed | GRIN Therapeutics, Inc. | 18 | 2025-05-20 | 2025-11-18 |
| Study to Evaluate the Pharmacokinetics and Safety Effects Following Coadministration of Carbamazepine or Itraconazole With Radiprodil in Healthy Adults Radiprodil with Carbamazepine, Radiprodil with Itraconazole - Tuberous Sclerosis Complex (TSC), Focal Cortical Dysplasia | Phase 1 | Terminated | GRIN Therapeutics, Inc. | 30 | 2025-05-08 | 2025-11-21 |
| Astroscape: A Study of Radiprodil on Safety, Tolerability, Pharmacokinetics, and Effect on Seizures and Behavioral Symptoms in Patients With TSC or FCD Type II Radiprodil - Tuberous Sclerosis Complex, Focal Cortical Dysplasia | Phase 1 / Phase 2 | Active not recruiting | GRIN Therapeutics, Inc. | 30 | 2024-07-10 | 2026-04-01 |
| Honeycomb: Evaluation of Radiprodil in Children with GRIN-related Disorder Radiprodil - GRIN-related Disorders | Phase 1 | Active not recruiting | GRIN Therapeutics, Inc. | 24 | 2023-03-07 | 2024-11-15 |
| A Phase 2 Study of Radiprodil in Subjects With Drug-resistant Infantile Spasms (IS) Radiprodil - Infantile Spasms (IS) | Phase 2 | Terminated | UCB Biopharma S.P.R.L. | 3 | 2017-12-04 | 2019-09-17 |
| Study to Evaluate Properties of Radiprodil Given in Oral Solution to Healthy Volunteers Radiprodil oral - Healthy Volunteers | Phase 1 | Completed | UCB Biopharma S.P.R.L. | 10 | 2016-01-01 | 2016-02-10 |
Focal Cortical Dysplasia (3) · Tuberous Sclerosis (3) · Epilepsy (1) · Spasm (1) · Spasms, Infantile (1)
GRIN Therapeutics, Inc. (7) · UCB Biopharma S.P.R.L. (2)
Australia (4) · Netherlands (4) · United States (4) · Italy (3) · Spain (3) · United Kingdom (3) · Belgium (2) · Canada (2) · France (2) · Germany (2) · Poland (2) · Slovenia (1)
Russell Chin (2) · Michael Panzara, MD, MPH (1) · Stephen Tisi (1) · Vijay Rai, PhD (1)
2015 (1), 2016 (1), 2023 (1)