217 completed, 43 recruiting, 41 unknown, 22 active not recruiting. 123 Not applicable, 70 Phase 2, 51 Phase 1, 34 Phase 3, 16 Phase 4.
Follow Neoplasms, Multiple Primary: new trials by email Literature Review of Neoplasms, Multiple Primary trials Research Report on Neoplasms, Multiple Primary
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Acute Effects of Ketone Monoester Co-Ingestion With Dietary Protein on Whole-Body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Older Males Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise - Ketosis, Resistance Exercise | Not applicable | Not yet recruiting | McGill University | 18 | 2026-11-01 | 2026-10-20 |
| Acute Effects of Ketone Monoester Co-ingestion With Dietary Protein on Whole-body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Young Males. Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise - Post-exercise Period, Ketosis | Not applicable | Recruiting | McGill University | 18 | 2026-10-23 | 2026-10-23 |
| Neurocutaneous Syndromes in Children: Prevalence and Clinical Characteristics Sturge-Weber Syndrome, Neurocutaneous Syndromes | Not yet recruiting | Assiut University | 100 | 2026-09-20 | 2026-09-28 | |
| Safety and Efficacy of AV078 in Participants With Tuberous Sclerosis Complex (TSC) Refractory Epilepsy (RESTOR-1) AV078, Placebo - Tuberous Sclerosis Complex, Epilepsy | Phase 2 | Not yet recruiting | Aeovian Pharmaceuticals, Inc. | 42 | 2026-09-01 | 2026-09-29 |
| Double-Blind Trial of Everolimus for Improving Social Abilities in PTEN Germline Mutations Everolimus blinded oral capsules, Placebo - Cowden's Disease, Cowden's Syndrome | Phase 2 / Phase 3 | Not yet recruiting | Boston Children's Hospital | 60 | 2026-09-01 | 2026-06-04 |
| Cardiovascular Effects of Purple-Fleshed Potatoes Purple flesh potato, White flesh potato - PRE-HYPERTENSION | Not applicable | Not yet recruiting | Instituto de Investigacion Nutricional, Peru | 300 | 2026-08-01 | 2026-07-29 |
| Safety, Tolerability, and Pharmacokinetics of SVG103 (Paxalisib) in Focal Cortical Dysplasia Type II (FCD-II), Tuberous Sclerosis Complex (TSC) or Hemimegalencephaly (HME) SVG103 - Focal Cortical Dysplasia, Tuberous Sclerosis Complex (TSC) | Phase 1 / Phase 2 | Recruiting | Sovargen | 12 | 2026-07-14 | 2026-08-10 |
| FOsfomycin for Male Urinary Tract Infection Fosfomycun-trometamol - Urinary Tract Infection, Prostatitis | Phase 3 | Not yet recruiting | University Hospital, Rouen | 138 | 2026-07-01 | 2026-06-12 |
| Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY) Perimenopause, Perimenopause-Related Depression | Enrolling by invitation | Healing Hope International | 12 | 2026-06-01 | 2026-04-06 | |
| Periodontal Disease in Rare Renal Disorders (PERIO-RA-RE) Observational assessment - Periodontal Disease, Periodontitis | Recruiting | Stefan Lujinschi | 100 | 2026-05-04 | 2026-06-26 | |
| Accuracy of 18F-Fluorocholine PET/MR and NeuroEXPLORER PET/CT Imaging for Localization of Parathyroid Tumors 18F-FCH, NeuroEXPLORER - Primary Hyperparathyroidism, Parathyroid Cancer | Phase 2 / Phase 3 | Recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 193 | 2026-04-16 | 2026-10-29 |
| Proof-of-Concept Trial to Assess the Efficacy and Safety of Fezolinetant in Improving Vasomotor Symptoms in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy fezolinetant - reference formulation, Placebo - Prostate Cancer, Prostate Cancer (Adenocarcinoma) | Phase 2 | Recruiting | Shehzad Basaria, M.D. | 60 | 2026-01-14 | 2026-08-17 |
| A Smart Phone Application to Improve Adoption of the 2024 Kidney Disease Improving Global Outcomes (KDIGO) Chronic Kidney Disease (CKD) Guidelines Use of an electronic digital Application - Chronic Kidney Disease, Proteinuria | Not applicable | Recruiting | St. James's Hospital, Ireland | 80 | 2026-01-14 | 2026-05-01 |
| Sapu003 in Advanced mTOR-sensitive Solid Tumors Sapu003, Exemestane 25 MG - Breast Cancer Metastatic, Renal Cell Carcinoma (RCC) | Phase 1 | Recruiting | SAPU NANO (US) LLC | 27 | 2025-12-15 | 2026-01-27 |
| Immersive Group Dance in Virtual Reality and Perceived Social Cohesion in Older Adults Immersive VR Group Dance Program, Conventional Light Physical Activity Program - Social Cognition, Healthy Aging | Not applicable | Completed | Islamic Azad University, Sanandaj | 180 | 2025-11-01 | 2026-10-06 |
| TANDem-2: Closing the Gap to Interventions for TAND Well-Beans for Caregivers Program - Adult Caregivers of Individuals With TSC, Tuberous Sclerosis Complex (TSC) | Not applicable | Enrolling by invitation | Vrije Universiteit Brussel | 30 | 2025-07-15 | 2025-09-22 |
| Institution of an Italian Multicenter Database of Patients With Multiple Endocrine Neoplasia Type 1 (MENNET1 Database) Multiple Endocrine Neoplasia Type 1 | Not yet recruiting | F.I.R.M.O. - Fondazione Italiana Ricerca sulle Malattie dell'Osso - Ente del Terzo Settore | 600 | 2025-06-01 | 2025-01-27 | |
| Phase 1, Open-label, Drug-drug Interaction Study to Assess Effect Between Radiprodil and the Co-administered Drugs. Radiprodil + co-administered drugs - Tuberous Sclerosis Complex (TSC), Focal Cortical Dysplasia | Phase 1 | Completed | GRIN Therapeutics, Inc. | 18 | 2025-05-20 | 2025-11-18 |
| Gamified Virtual Reality Exercise for Suicidal Ideation in Older Adults Gamified VR-Based Exercise Program, Conventional Exercise Program - Suicidal Ideation, Mental Health | Not applicable | Completed | Islamic Azad University, Sanandaj | 200 | 2025-05-10 | 2026-10-07 |
| Study to Evaluate the Pharmacokinetics and Safety Effects Following Coadministration of Carbamazepine or Itraconazole With Radiprodil in Healthy Adults Radiprodil with Carbamazepine, Radiprodil with Itraconazole - Tuberous Sclerosis Complex (TSC), Focal Cortical Dysplasia | Phase 1 | Terminated | GRIN Therapeutics, Inc. | 30 | 2025-05-08 | 2025-11-21 |
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Multiple Endocrine Neoplasia Type 1 (193) · Tuberous Sclerosis (114) · Epilepsy (24) · Hamartoma Syndrome, Multiple (21) · Obesity (20) · Multiple Endocrine Neoplasia (17) · Lymphangioleiomyomatosis (16) · Multiple Endocrine Neoplasia Type 2a (15) · Seizures (15) · Autistic Disorder (13) · Breast Neoplasms (12) · Neoplasms (12) · Neuroendocrine Tumors (11) · Motor Activity (10) · Overweight (10)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (353) · Genetic Diseases, Inborn (349) · Neoplasms (347) · Neoplastic Syndromes, Hereditary (347) · Neoplasms by Site (229) · Endocrine System Diseases (224) · Endocrine Gland Neoplasms (219) · Multiple Endocrine Neoplasia (201) · Hamartoma (137) · Nervous System Diseases (136) · Congenital Abnormalities (126) · Neurodegenerative Diseases (121) · Heredodegenerative Disorders, Nervous System (119) · Nervous System Malformations (119)
Everolimus (21) · Sirolimus (18) · Cannabidiol (6) · Eating (5) · Exercise (5) · Fulvestrant (5) · Surveys and Questionnaires (4) · Activator Appliances (3) · Alpelisib (3) · Diet (3) · Miransertib (3) · Resistance Training (3) · Sodium Chloride (3) · Standard of Care (3) · Vigabatrin (3)
Novartis Pharmaceuticals (13) · Bayer (12) · University of California, Los Angeles (9) · National Cancer Institute (NCI) (8) · Children's Hospital Medical Center, Cincinnati (7) · Jazz Pharmaceuticals (6) · M.D. Anderson Cancer Center (6) · The Hospital for Sick Children (6) · Boston Children's Hospital (5) · National Heart, Lung, and Blood Institute (NHLBI) (5) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (5) · Arizona State University (4) · GlaxoSmithKline (4) · National Human Genome Research Institute (NHGRI) (4) · University of Pennsylvania (4)
United States (163) · Canada (41) · France (31) · United Kingdom (30) · Australia (27) · Spain (24) · Italy (22) · Germany (20) · Netherlands (20) · China (19) · Belgium (16) · Poland (15) · Taiwan (11) · South Korea (10) · Denmark (9)
Smita Jha, M.D. (4) · Darcy Krueger, MD, PhD (3) · Joel Moss, M.D. (3) · Leslie G Biesecker, M.D. (3) · Mustafa Sahin, MD, PhD (3) · Nancy D. Perrier, MD (3) · Anna Jansen, MD, PhD (2) · Antoni Gostynski, MD, PhD (2) · Antonio Hardan, MD (2) · Dennis J Dlugos, MD (2) · Gwendolyn Portzky, PhD (2) · Hope Northrup, MD (2)
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