14 completed. 14 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 14 | Completed 14 |
| Phase 3 | 1 | Completed 1 |
Follow Filariasis: new trials by email Literature Review of Filariasis trials Research Report on Filariasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Trial Evaluating the Safety and Efficacy of Moxidectin 2 mg Ivermectin-controlled in Loa Loa Microfilaremic Patients Moxidectin 2 MG Oral Tablet, Ivermectin 3Mg Tab, Placebo oral tablet - Onchocerciasis, Ocular, Loiasis | Phase 2 | Completed | Center for Research on Filariasis and Other Tropical Diseases, Cameroon | 72 | 2022-04-07 | 2025-02-24 |
| Clinical Trial Evaluating the Safety and Efficacy of Levamisole in Loa Loa Microfilaremic Patients LEV 1 mg/kg, LEV 1,5 mg/kg, LEV 2,5 mg/kg - Onchocerciasis, Ocular, Loiasis | Phase 2 | Completed | Programme National de Lutte contre l'Onchocercose, Republic of the Congo | 255 | 2021-01-16 | 2021-09-20 |
| Safety and Efficacy of IDA for Onchocerciasis IVM w/ ALB, Single dose of IDA, Three daily doses of IDA - Onchocerciasis | Phase 2 | Completed | Washington University School of Medicine | 154 | 2019-12-06 | 2024-06-04 |
| PK PD Study of IDA and Azithromycin for NTDs ( ComboNTDs ) Azithromycin, Albendazole, Ivermectin - Lymphatic Filariasis, Yaws | Phase 2 | Completed | Lihir Medical Centre | 42 | 2018-09-01 | 2019-02-28 |
| Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study Ivermectin, Albendazole - Malaria, Lymphatic Filariasis | Phase 2 / Phase 3 | Completed | Colorado State University | 2712 | 2015-06-01 | 2019-01-04 |
| Concomitant Infections of Mansonella Perstans in Tuberculosis and Buruli Ulcer Disease Patients From Ghana Doxycycline - Mansonella Perstans Infection, Buruli Ulcer | Phase 2 | Completed | Kwame Nkrumah University of Science and Technology | 200 | 2014-10-01 | 2017-03-23 |
| Eval 3-Drug Therapy Diethylcarbamize, Albendazole and Ivermectin That Could Accelerate LF Elimination Outside of Africa Diethylcarbamazine, Albendazole, Ivermectin - Lymphatic Filariasis | Phase 2 | Completed | University Hospitals Cleveland Medical Center | 182 | 2014-05-01 | 2018-10-09 |
| Reslizumab to Prevent Post-treatment Eosinophilia in Loiasis Reslizumab, Diethylcarbamazine, Placebo - Loiasis | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 31 | 2010-04-01 | 2022-01-27 |
| Effect of Albendazole Dose on Treatment of Lymphatic Filariasis Albendazole, Diethylcarbamazine - Lymphatic Filariasis | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 40 | 2007-07-01 | 2015-08-31 |
| Effect of Albendazole Dose on Clearance of Filarial Worms DEC/Albendazole - Lymphatic Filariasis, Wuchereria Bancrofti Infection | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 1000 | 2006-09-09 | 2017-07-02 |
| Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection 2 mg moxidectin, ivermectin 150 mcg/kg, 4 mg moxidectin - Onchocerciasis | Phase 2 | Completed | Medicines Development for Global Health | 172 | 2006-09-06 | 2022-12-15 |
| Effect of Albendazole Dose on Clearance of Filarial Worms Albendazole, Ivermectin - Lymphatic Filariasis | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 1000 | 2006-02-22 | 2017-07-02 |
| Doxycycline to Treat Mansonella Perstans Infection in Patients With and Without Lymphatic Filariasis Doxycycline - Mansonella Perstans Infection, Mp Microfilaremia | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 1500 | 2004-12-06 | 2017-07-02 |
| Clinical Trial of Rifampin and Azithromycin for the Treatment of River Blindness Rifampin, Azithromycin - Onchocerciasis | Phase 2 | Completed | Centers for Disease Control and Prevention | 80 | 2003-07-01 | 2024-08-15 |
Elephantiasis, Filarial (6) · Loiasis (3) · Onchocerciasis (3) · Onchocerciasis, Ocular (3) · Mansonelliasis (2) · Buruli Ulcer (1) · Coinfection (1) · Dipetalonema Infections (1) · Enterobiasis (1) · Malaria (1) · Tuberculosis (1) · Wounds and Injuries (1) · Yaws (1)
Helminthiasis (14) · Infections (14) · Nematode Infections (14) · Parasitic Diseases (14) · Secernentea Infections (14) · Spirurida Infections (14) · Vector Borne Diseases (9) · Hemic and Lymphatic Diseases (6) · Lymphatic Diseases (6) · Lymphedema (6) · Mosquito-Borne Diseases (6) · Skin Diseases (5) · Skin and Connective Tissue Diseases (5) · Skin Diseases, Infectious (4)
Ivermectin (6) · Albendazole (5) · Diethylcarbamazine (4) · Albumins (2) · Azithromycin (2) · Doxycycline (2) · moxidectin (2) · Intravital Microscopy (1) · Levamisole (1) · Rifampin (1) · Tablets (1) · reslizumab (1)
National Institute of Allergy and Infectious Diseases (NIAID) (5) · Center for Research on Filariasis and Other Tropical Diseases, Cameroon (1) · Centers for Disease Control and Prevention (1) · Colorado State University (1) · Kwame Nkrumah University of Science and Technology (1) · Lihir Medical Centre (1) · Medicines Development for Global Health (1) · Programme National de Lutte contre l'Onchocercose, Republic of the Congo (1) · University Hospitals Cleveland Medical Center (1) · Washington University School of Medicine (1)
Ghana (3) · United States (3) · India (2) · Papua New Guinea (2) · Burkina Faso (1) · Cameroon (1) · Guatemala (1) · Mali (1) · Republic of the Congo (1)
Alexander Y Debrah, PhD (1) · Amy D Klion, M.D. (1) · Brian D. Foy, PhD (1) · Christopher King, MD, PhD (1) · Ellis Owusu Dabo, MBChB, PhD (1) · Gary Weil, MD (1) · Josef Amann, MD, MPH (1) · Nicholas Opoku, MB, CHB, MSC (1) · Nicholas Opoku, MD (1) · Peter Siba, PhD (1) · Richard Phillips O Phillips, MBChB, PhD (1) · Roch K Dabire, PhD (1) · Thomas B Nutman, M.D. (1)
PMID 19812401, PMID 24968000, PMID 26486704, PMID 28061905, PMID 30403937, PMID 30878222, PMID 32818264, PMID 34651190, PMID 37205721, PMID 37262040, PMID 38966851, PMID 42848323